Assessment of cognitive performance after progesterone administration in healthy male volunteers.

Abstract:

:Administration of progesterone produces sleep EEG patterns that resemble those of agonistic modulators at the GABAA receptor. Previous studies evaluating the effects of an oral progesterone administration on attention performance in females pointed to putative sedative effects of progesterone at high dosages. However, no data are available whether progesterone dosages that influence sleep produce sedative hangover effects on the following morning. Therefore, we assessed the effects of a single oral dose of 300 mg micronized progesterone administered in the evening on cognitive performance parameters in male healthy volunteers on the following morning using a placebo-controlled double-blind crossover design. There was a great variability in bioavailability following progesterone intake. The administration of progesterone produced no consistent effects on attention performance. Thus, dosages of progesterone that are sufficient to modulate sleep are not likely to exert sedative hangover effects.

journal_name

Neuropsychobiology

journal_title

Neuropsychobiology

authors

Grön G,Friess E,Herpers M,Rupprecht R

doi

10.1159/000119336

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

147-51

issue

3

eissn

0302-282X

issn

1423-0224

journal_volume

35

pub_type

临床试验,杂志文章,随机对照试验
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