Abstract:
:The possible involvement of anxiety and learning/memory processes in escape-directed (struggling) behavior in a two-trial swimming test was investigated in mice, as well as the differential effects that low doses of flumazenil (a benzodiazepine receptor antagonist) could display depending on the animals' anxiety levels. Mice showing less anxiety in the plus-maze test exhibited less struggling behavior in the first swimming trial than the more anxious animals, suggesting a relationship between anxiety and struggling behavior in the swimming test. Flumazenil (5 mg/kg) given before the first swimming trial displayed differential effects depending upon the animals' anxiety levels. Thus, it increased struggling behavior in the first swimming trial in 'low-anxiety' mice whereas the opposite tendency was observed in 'high-anxiety' animals. Struggling decreased in the second swimming trial in all the animals, giving support to the involvement of learning/memory processes in the two-trial swimming test. That reduction in escape-directed behavior was greater in animals treated with flumazenil before the first swimming session, thus indicating a slight enhancement of retention.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Ferré P,Fernández Teruel A,Escorihuela RM,García E,Zapata A,Tobeña Adoi
10.1159/000119058subject
Has Abstractpub_date
1994-01-01 00:00:00pages
23-7issue
1eissn
0302-282Xissn
1423-0224pii
119058journal_volume
29pub_type
杂志文章abstract::Personality traits were assessed in a series of 148 patients classified according to Winokur into depression pure disease (DPD), depression spectrum disease (DSD) and sporadic depression (SD) with the addition of a fourth group: family history positive-others (FH + .O) comprised of patients with psychiatric disorders ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117945
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:Eugen Bleuler, in his book Dementia praecox oder Gruppe der Schizophrenien, discussed issues of social psychiatry, and he considered complex interventions pivotal in the care for people with schizophrenia. Bleuler emphasised the potential of therapeutic communities in providing care, the drawbacks of extende...
journal_title:Neuropsychobiology
pub_type: 历史文章,杂志文章,评审
doi:10.1159/000338549
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Schizophrenia is a genetically complex disorder with an unknown pathophysiology. Several genes implicated in glutamate metabolism have been associated with the disorder. Recent studies of polymorphisms in the dystrobrevin-binding protein 1 gene (DTNBP1; dysbindin) and D-amino-acid-oxidase (DAO) gene, both in...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000235799
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:We examined striatal dopamine transporter (DAT) binding in bipolar and unipolar depressed patients and compared these values to those obtained from healthy control subjects using the selective DAT radioligand [(99m)Tc]TRODAT-1 and single photon emission computed tomography imaging. We hypothesized that DAT le...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000106476
更新日期:2007-01-01 00:00:00
abstract::In the search for differential mechanisms underlying clozapine's superior antipsychotic efficacy, the purinergic system has been considered, since an antagonist of the adenosine receptor A(2A) was shown to block clozapine acute effects on c-fos expression in rat striatum. Further investigating the interaction of cloza...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000054925
更新日期:2001-01-01 00:00:00
abstract::Fifteen general practitioners treated 21 newly diagnosed insomniac patients with benzodiazepines. In 15 cases, a short-acting benzodiazepine was prescribed without regard to the type, severity, duration and probable cause of insomnia. Sleep-wake ambulatory recordings were made at the respective homes of the patients b...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119461
更新日期:1990-01-01 00:00:00
abstract::Two preliminary studies have indicated a variation in season of birth in severely language-disordered children. In the current study, the season of birth in 472 Danish children with language disorder born between 1958 and 1976 was compared with the season of birth of all Danish live-born children in the same period. F...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000084166
更新日期:2005-01-01 00:00:00
abstract::The relationship between physical activity and mental health has been widely investigated, and several hypotheses have been formulated about it. Specifically, during the aging process, physical exercise might represent a potential adjunctive treatment for neuropsychiatric disorders and cognitive impairment, helping de...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000223730
更新日期:2009-01-01 00:00:00
abstract::A 56-year-old male parkinsonian patient developed a unique behavioral change following the oral administration of cinepazide, a cerebral vasodilator. This behavior consisted of an apparent infatuation with a ward nurse, which ceased after medication was discontinued. ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118040
更新日期:1984-01-01 00:00:00
abstract:INTRODUCTION:REM sleep behavior disorder (RBD) is considered a prodromal phase of α-synucleinopathy like Parkinson disease (PD). PD is characterized by a progressive decline of dopamine (DA) in the striatum. Here we report the surprising increase in DA transporter density over successive years in an RBD patient treated...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000488893
更新日期:2017-01-01 00:00:00
abstract::Neurobiological and pharmacological research has suggested that dysregulation of the central noradrenergic systems might be involved in the pathophysiology of attention deficit hyperactivity disorder (ADHD). Previous studies have demonstrated that the norepinephrine transporter gene (SLC6A2) is associated with ADHD. T...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000138916
更新日期:2008-01-01 00:00:00
abstract::The International Pharmaco-EEG Society (IPEG) presents updated guidelines summarising the requirements for the recording and computerised evaluation of pharmaco-EEG data in man. Since the publication of the first pharmaco-EEG guidelines in 1982, technical and data processing methods have advanced steadily, thus enhanc...
journal_title:Neuropsychobiology
pub_type: 指南,杂志文章,评审
doi:10.1159/000343478
更新日期:2012-01-01 00:00:00
abstract::During interictal periods in 9 patients with partial epilepsy we examined whether there were correlations between the relative power of background EEG (power spectral analysis) and the absolute values of regional cerebral blood flow (rCBF) measured by 99mTc hexamethylpropylene amine oxime (HMPAO) SPECT in each cerebra...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119135
更新日期:1994-01-01 00:00:00
abstract::Hallucinogenic drug-induced states are considered as models for acute schizophrenic disorders (experimental psychoses). In a double-blind study with healthy volunteers we investigated the influence of the serotonergic hallucinogen psilocybin, the ecstasy-like drug 3,4-methylenedioxyethylamphetamine (MDE), the stimulan...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000063672
更新日期:2002-01-01 00:00:00
abstract::In the present study all available young social alcohol abusers in the capital of Iceland are compared with a control group matched for age and intellectual level. Certain behaviour and social characteristics were found to occur more often during childhood among the abusers. Boys showing these characteristics should b...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117483
更新日期:1975-01-01 00:00:00
abstract::Twenty-three chronic undifferentiated schizophrenics, 13 women and 10 men, aged 37-64 years with 15-to 40-year histories of the disease were given either thyrotropin-releasing hormone (TRH) (10 subjects) or DDAVP (13 subjects) with the aim to improve the negative symptoms of the disease and memory. TRH (600 micrograms...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118253
更新日期:1986-01-01 00:00:00
abstract::Supine and standing heart rate (HR) and blood pressure measures were compared among 19 nonsmoking normal controls, 29 smoking patients and 36 nonsmoking patients with panic disorder. The smoking patients had a significantly higher supine HR, standing diastolic blood pressure, standing mean blood pressure and supine an...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119440
更新日期:1990-01-01 00:00:00
abstract::To evaluate the effect of the odor of incense on brain activity, electroencephalograms (EEGs) and event-related potentials (ERPs) in a push/wait paradigm were recorded in 10 healthy adults (aged 23-39 years) with normal olfactory function. EEG was recorded from 21 electrodes on the scalp, according to the Internationa...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000209859
更新日期:2009-01-01 00:00:00
abstract::Recent findings indicate that the memory-impairing effects of benzodiazepines may preferentially involve the basolateral nucleus of the amygdala. To test this hypothesis we examined the effects on pretrial injection of diazepam into the central as compared to the lateral/basolateral amygdaloid nuclei on memory for a c...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119209
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:C-reactive protein (CRP), a marker of underlying low-grade inflammation, has been associated with the pathophysiology of bipolar disorder. Additionally, bipolar disorder may be accompanied by functional or structural cerebral alterations. We attempted to discover whether serum high-sensitivity CRP (hs-CRP) le...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000353613
更新日期:2013-01-01 00:00:00
abstract::Diabetes mellitus can induce impairment in learning and memory. Cognitive and memory deficits are common in older adults and especially in those with diabetes. This is mainly because of hyperglycemia, oxidative stress, and vascular abnormalities. Coenzyme Q10 (CoQ10) can decrease oxidative stress, hyperglycemia, and i...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000495520
更新日期:2019-01-01 00:00:00
abstract::The effects of two benzodiazepines (alprazolam and bromazepam) on performance and event-related brain potentials (ERPs) in visual search and verbal recognition memory paradigms were tested in a placebo-controlled double-blind paradigm employing 12 young healthy subjects. Both drugs exerted similar effects on performan...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000119291
更新日期:1996-01-01 00:00:00
abstract::In 60 patients, hospitalized for a depressive syndrome, visual average evoked potentials (V .AEP) to stimuli of different intensities and the occurrence of life-events during the last year, as assessed by means of a specially constructed questionnaire, were investigated. Patients with an augmenter response in V .AEP, ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117773
更新日期:1980-01-01 00:00:00
abstract::Alcohol-dependent patients face a substantial risk of relapse after detoxification. Though psychosocial stress and coping strategies are regarded as major contributing factors in returning to drinking, the direct effects of coping styles on relapse are not clear. In this treatment outcome study, a mixed gender sample ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000096991
更新日期:2006-01-01 00:00:00
abstract::The genotypes of the CYP2E1 loci of 35 alcoholic and 130 nonalcoholic (healthy controls) Japanese were investigated to determine the relationship between CYP2E1 (C/D) polymorphism and susceptibility to alcohol dependence. There was a significant (d.f. = 1, chi2 = 11.0, p < 0.001) difference in the CYP2E1 C gene freque...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000026544
更新日期:1998-11-01 00:00:00
abstract::In the Lundby Study, all mental illnesses, treated as well as untreated, that occurred during a 25-year period in a geographically defined Swedish general population sample were evaluated. All forms of psychiatric services used by the population during the same period were registered. The present study investigates th...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117990
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:There is evidence that the nicotinic alpha7-acetylcholine receptor (alpha7-AChR) is involved in the pathophysiology of schizophrenia. Several neurotransmitter receptors, including alpha7-AChR, have been demonstrated on peripheral blood lymphocytes (PBL) and it has been suggested that these peripheral recepto...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000091725
更新日期:2006-01-01 00:00:00
abstract::This study investigated the acute effect of a dose range of low-to-moderate binge-like methamphetamine treatments on the regional expression of neurotrophin proteins in the brain and serum 2 h after the last dose, in addition to assessing the behavioural effects and dopamine neurotransmitter changes produced. Male Spr...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000480513
更新日期:2017-01-01 00:00:00
abstract::28 cases of suicide committed in a Swedish population subjected to repeated psychiatric investigations are described. Two groups of controls were selected from the same population: sex- and age-matched living persons (normal group) and sex-matched persons who had died from organic disease at ages corresponding to thos...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117666
更新日期:1979-01-01 00:00:00
abstract::The efficacy and safety of tianeptine were compared, in the course of a multicentre randomised, double-blind, parallel group study, to those of placebo in the treatment of Major Depressions and Bipolar Disorder, Depressed with or without melancholia, without psychotic features. After a 1-week run-in placebo period, 12...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1159/000119326
更新日期:1997-01-01 00:00:00