Abstract:
:Supine and standing heart rate (HR) and blood pressure measures were compared among 19 nonsmoking normal controls, 29 smoking patients and 36 nonsmoking patients with panic disorder. The smoking patients had a significantly higher supine HR, standing diastolic blood pressure, standing mean blood pressure and supine and standing cardiac load measures compared to both patient nonsmokers and controls. There was no significant difference between controls and nonsmoking patients for any of the above measures except for the higher standing HR and the delta increase in HR upon standing in female panic disorder patients which suggests increased adrenergic activity. When lipid values of panic disorder patients (n = 92) were compared to National Reference Values for their sex and age for an increased risk of cardiovascular illness, there was no significant risk with regard to plasma levels of total cholesterol, high-density lipoprotein cholesterol or low-density lipoprotein cholesterol.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Yeragani VK,Pohl R,Balon R,Ramesh C,Glitz D,Sherwood Pdoi
10.1159/000119440subject
Has Abstractpub_date
1990-01-01 00:00:00pages
134-9issue
3eissn
0302-282Xissn
1423-0224journal_volume
23pub_type
杂志文章abstract::Neurobiological and pharmacological research has suggested that dysregulation of the central noradrenergic systems might be involved in the pathophysiology of attention deficit hyperactivity disorder (ADHD). Previous studies have demonstrated that the norepinephrine transporter gene (SLC6A2) is associated with ADHD. T...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000138916
更新日期:2008-01-01 00:00:00
abstract::The medical histories of 600 psychotic and 369 nonpsychotic subjects were examined for the occurrence of rheumatic chorea. There was significantly more rheumatic chorea in the histories of psychotic patients than in nonpsychotics (p less than 0.01, chi-square). Neuropathological associations are discussed. ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118234
更新日期:1986-01-01 00:00:00
abstract::The new anticonvulsant, lamotrigine, is becoming an important tool in the treatment of bipolar disorder, including bipolar depression. Its efficacy in bipolar depression might be linked to its inhibition of serotonin uptake. We present the case of a female schizoaffective patient successfully treated with 400 mg of la...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026538
更新日期:1998-10-01 00:00:00
abstract::Single, 50- and 100-mg oral doses of phenobarbital and a matching placebo were administered double-blind to 8 young, healthy male subjects. Multilead electroencephalographic (EEG) samples were recorded prior to, and at regular intervals within the 2 h following administration. The EEG signal was processed by power spe...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000119453
更新日期:1990-01-01 00:00:00
abstract::Dysfunctional mechanisms in the serotonergic system have been implicated in suicidal behavior among patients with schizophrenia. However, previous association analyses of major serotonin genes have provided inconsistent findings regarding their role in suicidal behavior. The goal of the current study was to identify s...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000441191
更新日期:2016-01-01 00:00:00
abstract::Analysis of the mechanisms underlying the clinical effects of different drugs is a vital part of psychopharmacology. It is fair to say, however, that such analyses have thus far met with little success. This lack of success can be traced to a variety of sources that have flawed the analytical process itself. Detailed ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118131
更新日期:1984-01-01 00:00:00
abstract::Failure to gain weight during withdrawal from chronic regimens of dependence-producing drugs is observed in laboratory rats. Withdrawal from the benzodiazepine anxiolytic agent diazepam, whether induced by cessation of treatment or precipitated by administration of the specific benzodiazepine antagonist Ro-15,1788, is...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118291
更新日期:1986-01-01 00:00:00
abstract::Morningness-eveningness preference by the self-rated Morningness-Eveningness Questionnaire (MEQ) has earlier been shown to be associated with the subjects' season of birth. Here, we obtain this result for a new sample of 2,125 university students and for the sample obtained by pooling the data with the earlier study, ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000067803
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:The present study investigated the effects of rapid tryptophan depletion (RTD), and the ensuing reduction of central nervous system levels of serotonin (5-HT), upon reactive aggression in patients with attention deficit/hyperactivity disorder (ADHD). Furthermore, it was asked whether the relation between 5-H...
journal_title:Neuropsychobiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000112951
更新日期:2007-01-01 00:00:00
abstract::Piracetam, when applied microiontophoretically and/or by hydropneumatic pump on the somatosensory cortex and hippocampus of the rat, affected neuronal activity by depressing or facilitating the spontaneous firing rate, depending on the area studied. Its effect were either additive or counteracting the actions of gluta...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118449
更新日期:1988-01-01 00:00:00
abstract::Like the industry, the medical profession takes now an interest in quality assurance programs. In the field of psychiatry, the quality assessment of antidepressive drug prescriptions is an ideal target. A brief review of previous studies reveals a high prevalence of the use of psychotropes among the general population...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000118618
更新日期:1989-01-01 00:00:00
abstract::Volunteers who develop a cold following virus challenge were significantly slower on choice reaction time tasks than those with no illness. This effect was still observed after the clinical symptoms had gone. In contrast to this, influenza illnesses only impaired performance in tasks in which subjects were uncertain w...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118558
更新日期:1989-01-01 00:00:00
abstract::Several antipsychotics and antidepressants have been associated with electrocardiogram alterations, the most clinically relevant of which is the heart rate-corrected QT interval (QTc) prolongation, a risk factor for sudden cardiac death. Genetic variants influence drug-induced QTc prolongation and can provide valuable...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000493400
更新日期:2019-01-01 00:00:00
abstract::The lithium RBC/plasma ratio was determined in 59 patients during prophylactic lithium therapy -- 10 cycloid psychotics, 28 unipolars and 21 bipolars -- as well as in 20 patients during lithium therapy in phase of illness -- 8 cycloid psychotics, 5 unipolars and 7 bipolars. The lithium ratio was found to be normally d...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117533
更新日期:1976-01-01 00:00:00
abstract::In 63 depressed patients, the associations between severity of depression, psychomotor retardation, assessed by the Bech-Rafaelsen Melancholia Scale, and EEG spectral analysis were examined. Slow EEG activity (theta 2/alpha 1 bands) was positively and fast activity (alpha 3/beta bands) negatively correlated with the o...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118804
更新日期:1992-01-01 00:00:00
abstract::Quantitative pharmaco-EEG has become a useful technique for determining pharmacodynamic parameters after CNS-active drug administration. Nevertheless, one of the most important problems faced by practitioners of pharmaco-EEG is the difficulty in evaluating drug-specific effects. In this article, a methodology for comp...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119068
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:In alcohol and other substance dependencies, patients often suffer relapse despite better knowledge and their intention to remain abstinent. A variety of neurotransmitter systems and their respective alterations due to the chronic drug intake are involved in mechanisms that facilitate relapse. It has been po...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000362838
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:Memory processes, as reflected by 'old/new' effects of event-related potentials (ERPs), have been shown to be impaired in depressed patients. This variability might be partly explained by biological factors. S100B is a glial calcium-binding protein with neuroplastic properties; S100B serum levels have been sh...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000219304
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Eugen Bleuler, in his book Dementia praecox oder Gruppe der Schizophrenien, discussed issues of social psychiatry, and he considered complex interventions pivotal in the care for people with schizophrenia. Bleuler emphasised the potential of therapeutic communities in providing care, the drawbacks of extende...
journal_title:Neuropsychobiology
pub_type: 历史文章,杂志文章,评审
doi:10.1159/000338549
更新日期:2012-01-01 00:00:00
abstract::The relationships between sensation seeking, curiosity about sex, and total and free testosterone in inmates were investigated. The role of other hormones such as luteinizing hormone (LH), follicle-stimulating hormone (FSH), and sex hormone-binding globulin (SHBG) in these relationships was also analyzed. Previous ana...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000082852
更新日期:2005-01-01 00:00:00
abstract::No consensus has been obtained about blood electrolyte status, especially about magnesium, in affective disorders. This is mainly due to the lack of information about the distribution of the patients in clinical subgroups, sex, type of treatment and about the severity of their illnesses. Most of these studies concerne...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118914
更新日期:1992-01-01 00:00:00
abstract::Eight patients with chronic obsessive-compulsive neurosis were subjected to trazodone, an antidepressant acting on the serotonergic system. After 4 weeks of treatment, 6 showed significant reduction in the obsessional symptoms which was sustained after a 6-week follow-up. The 2 patients who did not show improvement ha...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118274
更新日期:1986-01-01 00:00:00
abstract::Isolation causes important changes in the behavioral reactivity of rats to environmental stimuli. These changes include deficit in sensorimotor gating and altered fear-like responses to aversive stimuli. Measures of ultrasound vocalizations at 20-22 kHz when rats are exposed to threatening conditions, such as novelty,...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000085820
更新日期:2005-01-01 00:00:00
abstract::Clinical observations have suggested that lithium may exert adverse effects on memory. The difficulty in achieving empirical consensus regarding this issue has reflected several methodological problems: diversity of research designs, heterogeneous samples, lack of control groups and the possible confounding of memory ...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000118904
更新日期:1992-01-01 00:00:00
abstract::In the present study, single-unit extracellular recording was used in male Wistar rats to compare the effects of a single dose (acute treatment) and a 21-day regimen (long-term treatment) with clomipramine (2.5 mg/kg) and fluoxetine (1.0 mg/kg) on the spontaneous firing rate of nucleus accumbens (NAcc) neurons connect...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000073627
更新日期:2003-01-01 00:00:00
abstract::Time trends and periodic cycles in REM sleep eye movements were examined in 6 functional and 6 mongoloid adolescent retardates. Both groups of subjects showed approximately equal percentages of linear trends, quadratic trends, linear and quadratic trends, and absence of trend. The eye movement time-series were subject...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117524
更新日期:1976-01-01 00:00:00
abstract::Knowledge in neuropsychobiology continues to benefit from the use of drugs as 'tools' to alter neurochemical events as a means of studying interactions between the events and behaviour. Before drugs could play such a role, concepts about basic properties of living organism had to be refined. Techniques had to be inven...
journal_title:Neuropsychobiology
pub_type: 历史文章,杂志文章
doi:10.1159/000118407
更新日期:1987-01-01 00:00:00
abstract::Tetrahydrobiopterin (BH(4)) is a vital cofactor maintaining availability of the amine neurotransmitters [dopamine (DA), noradrenaline (NA), and serotonin (5-HT)], regulating the synthesis of nitric oxide (NO) by nitric oxide synthase (NOS), and stimulating and modulating the glutamatergic system (directly and indirect...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000089002
更新日期:2005-01-01 00:00:00
abstract::The effects of the dopaminergic agonists (L-dopa, pergolide) and antagonists (haloperidol, clozapin) and a cholinergic agonist (tacrine) and antagonist (mecamylamine) on the voluntary intake of nicotine were investigated with the 2-bottle paradigm with the test drugs being dissolved directly in the drinking fluid of t...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026661
更新日期:2000-01-01 00:00:00
abstract::Platelet 5-HT and plasma cortisol concentrations were determined in 59 schizophrenic patients with different time course of illness before and after dexamethasone suppression test (DST). An abnormal DST (nonsuppression) was observed in 51% of patients. In these patients basal cortisol and platelet 5-HT concentrations ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026493
更新日期:1998-01-01 00:00:00