Analysis of physiological mechanism in psychopharmacology.

abstract：:Saliva cortisol was measured at 11 p.m. in a sample of 74 psychiatric inpatients composed of 24 primary endogenous depressives, 40 secondary depressives and 20 nondepressives (DSM III and Saint-Louis criteria). Primary depressives had significantly higher 11 p.m. saliva cortisol levels than nondepressives (p less than...

journal_title：Neuropsychobiology

authors： Guéchot J,Lépine JP,Cohen C,Fiet J,Lempérière T,Dreux C

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Rasagiline and selegiline are classified as monoamine oxidase B (MAO-B) inhibitors. The present investigation deals with time-dependent electrical frequency changes (electropharmacograms) induced by these, as well as by aminoindan, the major metabolite of rasagiline. METHOD:Adult rats (day-night converted, ...

journal_title：Neuropsychobiology

authors： Dimpfel W,Hoffmann JA

更新日期：2010-01-01 00:00:00

abstract：:Ten closed head-injured patients and 10 matched control subjects participated in a study that examined quantitated EEG data during cognitive task performance. The head-injured patients performed significantly worse than controls on all four tasks and had significantly higher EEG amplitudes and amplitude variances. A d...

journal_title：Neuropsychobiology

authors： Randolph C,Miller MH

更新日期：1988-01-01 00:00:00

abstract：:Gamma-aminobutyric acid-B (GABAB) binding sites labelled with [3H]GABA were determined in postmortem frontal cortex samples of 20 control subjects and 16 suicides. The suicide group was further subdivided according to the method of suicide and the existence of depressive symptoms prior to death. No significant differe...

journal_title：Neuropsychobiology

authors： Arranz B,Cowburn R,Eriksson A,Vestling M,Marcusson J

更新日期：1992-01-01 00:00:00

abstract：:Recent studies suggest that the eye blink response to intense acoustic stimuli consists of two components that may occasionally result in waveforms with two peaks. In the present study, the prevalence, peak latencies, and peak magnitudes in responses exhibiting one or two peaks were investigated in healthy subjects in...

journal_title：Neuropsychobiology

authors： Meincke U,Light GA,Geyer MA,Braff DL

更新日期：2005-01-01 00:00:00

abstract：:Disturbances in the serotonergic neurotransmission system have been implicated in the etiology of attention deficit/hyperactivity disorder (ADHD). As the importance of genetic factors is well established, genes encoding for proteins of the serotonergic pathway are important candidates to unravel the underlying genetic...

journal_title：Neuropsychobiology

authors： Zoroglu SS,Erdal ME,Erdal N,Ozen S,Alasehirli B,Sivasli E

更新日期：2003-01-01 00:00:00

abstract：:46 severely depressed inpatients received 10-hour intravenous infusions supplying a dose of 720 mg dibenzepin daily on 2 or some cases 3 successive days. The patients were kept under close psychiatric surveillance and their cardiovascular function was carefully monitored. The shorter infusions were as effective as inf...

journal_title：Neuropsychobiology

authors： Gastpar M,Cornu F,Faessler J,Haefliger A,Keller H,von Lerber W,Pagan J,Rem J

更新日期：1984-01-01 00:00:00

abstract：:Time trends and periodic cycles in REM sleep eye movements were examined in 6 functional and 6 mongoloid adolescent retardates. Both groups of subjects showed approximately equal percentages of linear trends, quadratic trends, linear and quadratic trends, and absence of trend. The eye movement time-series were subject...

journal_title：Neuropsychobiology

authors： Krynicki V

更新日期：1976-01-01 00:00:00

abstract：:REM sleep behavior disorder (RBD) is so far a possibly underestimated yet well-described sleep disorder. Its major impact is the vigorous sleep behavior that often results in injuries to the patient himself or to people sleeping nearby. We treated a 64-year-old male with a clinically and polysomnographically confirmed...

journal_title：Neuropsychobiology

authors： Kunz D,Bes F

更新日期：1997-01-01 00:00:00

abstract：:Serum dopamine-beta-hydroxylase (DBH) levels were assessed in 150 depressed patients of both sexes, with a mean age of 44.0 +/- 12.3 (SD) years. Patients were divided into unipolars (n = 46), bipolars (n = 25), neurotic-reactive (n = 46) and unspecified (n = 38) i.e., those who did not fit into any of the previous cat...

journal_title：Neuropsychobiology

authors： Eisemann M,Ericsson U,Von Knorring L,Perris C,Perris H,Ross S

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Depressive disorder (DD) is characterized by an inflammatory process and oxidative stress. Cyclooxygenase-2 (COX-2), the expression of which increases in depression, is an enzyme involved in inflammation and free radical processes. The aim of our study was to assess the correlation between single nucleotide ...

journal_title：Neuropsychobiology

authors： Gałecki P,Florkowski A,Bieńkiewicz M,Szemraj J

更新日期：2010-01-01 00:00:00

abstract：:Volunteers who develop a cold following virus challenge were significantly slower on choice reaction time tasks than those with no illness. This effect was still observed after the clinical symptoms had gone. In contrast to this, influenza illnesses only impaired performance in tasks in which subjects were uncertain w...

journal_title：Neuropsychobiology

authors： Smith AP,Tyrrell DA,al-Nakib W,Barrow PG,Higgins PG,Leekam S,Trickett S

更新日期：1989-01-01 00:00:00

abstract：:A group of 27 patients with definite (n = 20) or probable (n = 7) RDC major depressive disorder underwent 2 sleep EEGs and 1 TRH test while in a drug-free depressive phase. A short mean REM latency (less than 60 min) identified 55.5% of major depressives while added use of blunted TSH responses (delta max. less than 5...

journal_title：Neuropsychobiology

authors： Pugnetti L,Scarone S,Brambilla F

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND AND AIM:Repetitive transcranial magnetic stimulation (rTMS) is supposed to be not as effective in severe depression as it is in medium depression. We evaluated the treatment response to an ultra-high-frequency (UHF; 30 Hz) approach, which was used to maximize the rTMS efficacy in severely ill patients. METH...

journal_title：Neuropsychobiology

authors： Ullrich H,Kranaster L,Sigges E,Andrich J,Sartorius A

更新日期：2012-01-01 00:00:00

abstract：:Gamma oscillations (>30 Hz) in the brain are involved in attention, perception and memory. They are altered in various pathological states, as well as by neuropharmaceuticals, so that they are of interest in drug and clinical investigations. However, when the human electroencephalogram is recorded on the scalp, this n...

journal_title：Neuropsychobiology

authors： Nottage JF,Horder J

更新日期：2015-01-01 00:00:00

abstract：:The effects of two benzodiazepines (alprazolam and bromazepam) on performance and event-related brain potentials (ERPs) in visual search and verbal recognition memory paradigms were tested in a placebo-controlled double-blind paradigm employing 12 young healthy subjects. Both drugs exerted similar effects on performan...

journal_title：Neuropsychobiology

authors： Münte TF,Gehde E,Johannes S,Seewald M,Heinze HJ

更新日期：1996-01-01 00:00:00

abstract：:Little is known about the effects of cocaine on cognitive tasks. Event-related potentials (ERP) were recorded in 7 cocaine abusers during the performance of the auditory oddball task before and after the intravenous injections of saline and cocaine (60-80 mg). The P3B and slow wave components of the ERP were significa...

journal_title：Neuropsychobiology

authors： Herning RI,Glover BJ,Guo X

更新日期：1994-01-01 00:00:00

abstract：:Twenty-three chronic undifferentiated schizophrenics, 13 women and 10 men, aged 37-64 years with 15-to 40-year histories of the disease were given either thyrotropin-releasing hormone (TRH) (10 subjects) or DDAVP (13 subjects) with the aim to improve the negative symptoms of the disease and memory. TRH (600 micrograms...

journal_title：Neuropsychobiology

authors： Brambilla F,Aguglia E,Massironi R,Maggioni M,Grillo W,Castiglioni R,Catalano M,Drago F

更新日期：1986-01-01 00:00:00

abstract：:The search for specific predepressive personality factors has a long tradition in psychiatry. Studies in which assessments were made prospectively, before the onset of a first-ever episode of the illness, are, however, rare. In the present report from the Lundby Study we have investigated premorbid, mainly personality...

journal_title：Neuropsychobiology

authors： Rorsman B,Gräsbeck A,Hagnell O,Isberg PE,Otterbeck L

更新日期：1993-01-01 00:00:00

abstract：:The acute effects of alcohol (0.7 g/kg) on visual signal detection performance and critical flicker fusion frequency (CFF) of normal volunteers were investigated using a signal detection theory analysis. When signal probability was low, alcohol affected the stimulus sensitivity and the reaction times of hits. Under a ...

journal_title：Neuropsychobiology

authors： Jansen AA,de Gier JJ,Slangen JL

更新日期：1985-01-01 00:00:00

abstract：:Sleep apnea is the most common sleep-related breathing disorder characterized by repetitive episodes of hypoxemia. Therapies include behavioral, surgical, orthodontic, pneumological, and pharmacological interventions. The aim of the present study was to compare the efficiency of pneumological therapy by nasal continuo...

journal_title：Neuropsychobiology

authors： Saletu B,Oberndorfer S,Anderer P,Gruber G,Divos H,Lachner A,Mandl M,Parapatics S,Popp W,Saletu M,Saletu-Zyhlarz G,Sertl K,Strobl R,Tschida U,Winkler A

更新日期：1999-01-01 00:00:00

abstract：:Actions of the new antiepileptic drug lamotrigine (LTG) were characterized using extracellular and whole cell patch clamp recordings from rat CA1 and CA3 pyramidal cells in vitro. The results suggest that LTG, beside its previously described effect on the fast sodium inward current, also modulates - presumably voltage...

journal_title：Neuropsychobiology

authors： Grunze H,von Wegerer J,Greene RW,Walden J

更新日期：1998-10-01 00:00:00

abstract：:The authors recorded contingent negative variation (CNV) in a group of subjects affected by presenile dementia, at the onset of the symptoms, with a slight degree of intellectual deterioration. Recordings were carried out in rest basal conditions and upon administration of an insignificant distracting stimulus. Result...

journal_title：Neuropsychobiology

authors： Rizzo PA,Albani G,Cicardi C,Spadaro M,Morocutti C

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVE:Olfactory processing depends on dopamine metabolism and orbitofrontal cortex functioning, both known to be disturbed in attention-deficit/hyperactivity disorder (ADHD). Some investigations suggested alterations in olfactory processing (identification and sensitivity) in childhood and adult ADHD. METHODS:In t...

journal_title：Neuropsychobiology

authors： Schecklmann M,Schenk E,Maisch A,Kreiker S,Jacob C,Warnke A,Gerlach M,Fallgatter AJ,Romanos M

更新日期：2011-01-01 00:00:00

abstract：:To evaluate the effect of the odor of incense on brain activity, electroencephalograms (EEGs) and event-related potentials (ERPs) in a push/wait paradigm were recorded in 10 healthy adults (aged 23-39 years) with normal olfactory function. EEG was recorded from 21 electrodes on the scalp, according to the Internationa...

journal_title：Neuropsychobiology

authors： Iijima M,Osawa M,Nishitani N,Iwata M

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The failure to inhibit pleasurable but inappropriate urges is associated with frontal lobe pathology and has been suggested as a possible cause of pedophilic behavior. However, imaging and neuropsychological findings about frontal pathology in pedophilia are heterogeneous. In our study we therefore address i...

journal_title：Neuropsychobiology

authors： Habermeyer B,Esposito F,Händel N,Lemoine P,Kuhl HC,Klarhöfer M,Mager R,Mokros A,Dittmann V,Seifritz E,Graf M

更新日期：2013-01-01 00:00:00

abstract：AIMS:The aim was to measure the prefrontal cortical activity involved in shifting spatial attention to visual stimuli in the left or right visual field using near-infrared spectroscopy. METHODS:Eleven participants performed a simple vigilance task, an endogenous attention task and an exogenous attention task. In the e...

journal_title：Neuropsychobiology

authors： Takahashi M,Ikegami M

更新日期：2008-01-01 00:00:00

abstract：:Dopamine depletion induced by administration of Ro4-1284 produces a condition of rapid and repeated eye blinking in rats. This condition mimics the human disorder, blepharospasm, which often accompanies parkinsonism and other dopamine deficiency disorders. When given a 3-week course of a compound (SR-3) developed from...

journal_title：Neuropsychobiology

authors： Mostofsky DI,Yehuda S,Rabinovitz S,Carasso R

更新日期：2000-01-01 00:00:00

abstract：:The relationship between physical activity and mental health has been widely investigated, and several hypotheses have been formulated about it. Specifically, during the aging process, physical exercise might represent a potential adjunctive treatment for neuropsychiatric disorders and cognitive impairment, helping de...

journal_title：Neuropsychobiology

authors： Deslandes A,Moraes H,Ferreira C,Veiga H,Silveira H,Mouta R,Pompeu FA,Coutinho ES,Laks J

更新日期：2009-01-01 00:00:00

abstract：:No consensus has been obtained about blood electrolyte status, especially about magnesium, in affective disorders. This is mainly due to the lack of information about the distribution of the patients in clinical subgroups, sex, type of treatment and about the severity of their illnesses. Most of these studies concerne...

journal_title：Neuropsychobiology

authors： Widmer J,Bovier P,Karege F,Raffin Y,Hilleret H,Gaillard JM,Tissot R

更新日期：1992-01-01 00:00:00