Abstract:
:Time trends and periodic cycles in REM sleep eye movements were examined in 6 functional and 6 mongoloid adolescent retardates. Both groups of subjects showed approximately equal percentages of linear trends, quadratic trends, linear and quadratic trends, and absence of trend. The eye movement time-series were subject to an orthogonal spectral analysis. In both groups of subjects, peak spectral estimates generally occurred at 10.6- or 21.3-min periods. Following this, the eye movements of the longest REM periods (and one long period of pre-sleep wakefulness) were subject to a least-squares spectral analysis. This analysis yielded estimates ranging from 22 to 44 min. Eye movements lacked the ultradian organization previously reported for eye movements of normal subjects. These results imply that the ultradian organization of REM sleep and the ultradian organization of eye movements may be independent.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Krynicki Vdoi
10.1159/000117524subject
Has Abstractpub_date
1976-01-01 00:00:00pages
9-17issue
1eissn
0302-282Xissn
1423-0224journal_volume
2pub_type
杂志文章abstract::Knowledge in neuropsychobiology continues to benefit from the use of drugs as 'tools' to alter neurochemical events as a means of studying interactions between the events and behaviour. Before drugs could play such a role, concepts about basic properties of living organism had to be refined. Techniques had to be inven...
journal_title:Neuropsychobiology
pub_type: 历史文章,杂志文章
doi:10.1159/000118407
更新日期:1987-01-01 00:00:00
abstract:AIM:We describe the difficulties encountered in making a diagnosis where a somatic condition manifests itself alongside psychiatric symptoms associated with possible psychiatric comorbidities. METHODS:A case study is presented of a 15-year-old girl who was eventually diagnosed with ornithine transcarbamylase (OTC) def...
journal_title:Neuropsychobiology
pub_type:
doi:10.1159/000508679
更新日期:2020-07-20 00:00:00
abstract::In 60 patients, hospitalized for a depressive syndrome, visual average evoked potentials (V .AEP) to stimuli of different intensities and the occurrence of life-events during the last year, as assessed by means of a specially constructed questionnaire, were investigated. Patients with an augmenter response in V .AEP, ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117773
更新日期:1980-01-01 00:00:00
abstract::Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine and these neurotransmitters are hypothesized to be involved in the cognitive function of humans. This study of a cohort of 191 healthy young Chinese females attempts to utilize the intelligence qu...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000086609
更新日期:2005-01-01 00:00:00
abstract::Cerebral impedance changes (F changes) indicating cerebral blood flow variations in the central and precentral areas were measured with a rheographic technique in normal subjects preparing for and carrying out a motor task. The time course of the F changes was studied and several significant correlations were establis...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117609
更新日期:1977-01-01 00:00:00
abstract::Neurobiological and pharmacological research has suggested that dysregulation of the central noradrenergic systems might be involved in the pathophysiology of attention deficit hyperactivity disorder (ADHD). Previous studies have demonstrated that the norepinephrine transporter gene (SLC6A2) is associated with ADHD. T...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000138916
更新日期:2008-01-01 00:00:00
abstract::As low-dose amphetamine stimulation of locomotor activity in the rat depends upon a mesolimbic dopaminergic substrate, neuroleptic antagonism of this behavior has been suggested as a model for studying antipsychotic activity. Animals in the present study received 21 days of chronic treatment with 1.0 mg/kg amphetamine...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118442
更新日期:1988-01-01 00:00:00
abstract::1,927 outpatients were included by 392 general practitioners in an open study in order to evaluate the safety of tianeptine in the ambulatory treatment of depression. The results of 1,858 depressed patients without melancholia and psychotic features, fulfilling DSM III criteria of Major Depressive Episode or Dysthymic...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118824
更新日期:1992-01-01 00:00:00
abstract::Volunteers who develop a cold following virus challenge were significantly slower on choice reaction time tasks than those with no illness. This effect was still observed after the clinical symptoms had gone. In contrast to this, influenza illnesses only impaired performance in tasks in which subjects were uncertain w...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118558
更新日期:1989-01-01 00:00:00
abstract::Actions of the new antiepileptic drug lamotrigine (LTG) were characterized using extracellular and whole cell patch clamp recordings from rat CA1 and CA3 pyramidal cells in vitro. The results suggest that LTG, beside its previously described effect on the fast sodium inward current, also modulates - presumably voltage...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026528
更新日期:1998-10-01 00:00:00
abstract::The brain activity of 13 right-handed students (6 men and 7 women) was determined using high resolution (99m)Tc-HMPAO brain SPECT images during visuospatial tasks. The results showed that there was no significant gender-specific difference in solving the visuospatial tasks and that no meaningful statistical difference...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026639
更新日期:2000-01-01 00:00:00
abstract::Three anxiolytic drugs (bromazepam 3 mg, buspirone 10 mg, and clobazam 10 mg p.o.) were evaluated for their effects on memory, psychomotor performance and subjective response in a double-blind, placebo-controlled, crossover study in 20 healthy volunteers. At each session, measurements were made before and 2 and 6 h af...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000118609
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:So-called Porteus mazes are used to investigate prefrontal cortex (PFC) functioning in normal subjects and patients with different neuropsychiatric disorders. Here we present data confirming the involvement of the PFC for the first time by means of functional magnetic resonance imaging (fMRI). To minimize mo...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000095742
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:The characterization of an individual's hypothalamic-pituitary-adrenal axis stress response is a main research topic in neuropsychobiology since alterations have been causally linked to several disease states. Over the last years, several studies focused on the identification of sources of inter- and intrain...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000115783
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Patients with bipolar disorder are at a high risk for becoming obese. Adipokines are associated with depression and obesity via the inflammatory process. However, few studies have investigated the associations between depression and leptin, adiponectin and resistin levels in patients with bipolar disorder. W...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000366488
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Abnormalities in different parameters of the norepinephrine system have been widely described in major depression. The presence of alpha(2)-adrenoreceptors in blood platelets, similar to those in the brain, prompted us to evaluate them in depressed patients, as compared with healthy controls. METHODS:Fiftee...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000054930
更新日期:2001-01-01 00:00:00
abstract::A group of 27 patients with definite (n = 20) or probable (n = 7) RDC major depressive disorder underwent 2 sleep EEGs and 1 TRH test while in a drug-free depressive phase. A short mean REM latency (less than 60 min) identified 55.5% of major depressives while added use of blunted TSH responses (delta max. less than 5...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118350
更新日期:1987-01-01 00:00:00
abstract::Diabetes mellitus can induce impairment in learning and memory. Cognitive and memory deficits are common in older adults and especially in those with diabetes. This is mainly because of hyperglycemia, oxidative stress, and vascular abnormalities. Coenzyme Q10 (CoQ10) can decrease oxidative stress, hyperglycemia, and i...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000495520
更新日期:2019-01-01 00:00:00
abstract::The region coding human leukocyte antigen (HLA) on chromosome 6q21 was shown to be associated with both the vulnerability to schizophrenia and presence of eye movement disturbances (EMD). The aim of this preliminary study was to investigate how individual class I and II HLA antigens in schizophrenic patients may be re...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000085595
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Stress is a precipitating factor for both binge eating and bulimia nervosa (BN); however, the biological mechanisms through which it may trigger binge eating are poorly understood. There is evidence that the adrenal hormone cortisol and the gastric peptide ghrelin might be involved in stress-induced food ing...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000341877
更新日期:2012-01-01 00:00:00
abstract::The formerly designed method for quantitative evaluation of drug effects in rats is employed for the classification of three different neuroleptic drugs, namely sulpiride, clozapine and haloperidol. Analysis of the power density spectra as obtained from the recorded activity in the cortex, striatum and reticular core ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118220
更新日期:1985-01-01 00:00:00
abstract::In the present study, single-unit extracellular recording was used in male Wistar rats to compare the effects of a single dose (acute treatment) and a 21-day regimen (long-term treatment) with clomipramine (2.5 mg/kg) and fluoxetine (1.0 mg/kg) on the spontaneous firing rate of nucleus accumbens (NAcc) neurons connect...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000073627
更新日期:2003-01-01 00:00:00
abstract::The focus is on evaluating the relationships between early behavioural problems and biochemical variables at adult age and their significance for early criminality and violent behaviour in a life perspective. In the present study, using prospective longitudinal data, a sample of males with a history of early criminal ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000087557
更新日期:2005-01-01 00:00:00
abstract::To examine volumetric abnormality, the caudate nucleus was measured in patients with schizophrenia and healthy subjects using magnetic resonance imaging. The absolute and relative volumes of white matter in the caudate nucleus were found to be significantly smaller in patients with schizophrenia compared to those in h...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000080956
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND/AIMS:Previous functional neuroimaging studies have reported that patients with schizophrenia show reduced prefrontal activation during cognitive tasks whereas patients with schizotypal personality disorder (SPD) show preserved or even increased right prefrontal activation, compared to healthy controls; on th...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000129669
更新日期:2008-01-01 00:00:00
abstract::The effects of zolpidem or zaleplon on sleep architecture, respiratory patterns and performance were assessed at a simulated altitude of 4,000 m. Twelve male healthy subjects spent 4 nights in a decompression chamber, 1 at sea level (baseline), 3 at 4,000 m to test zolpidem (10 mg), zaleplon (10 mg) and placebo, given...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000076723
更新日期:2004-01-01 00:00:00
abstract::Carnitine is essential for mitochondrial energy production. Disturbance in mitochondrial function may contribute to or cause the fatigue seen in chronic fatigue syndrome (CFS) patients. One previous investigation has reported decreased acylcarnitine levels in 38 CFS patients. We investigated 35 CFS patients (27 female...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119226
更新日期:1995-01-01 00:00:00
abstract::We agree with the conclusions of a recent article in this journal [James, Neuropsychobiology 1994;30:124-125] that studies on the psychoactive effects of caffeine need to take into account the possibility that the results obtained might represent merely the reversal of deleterious effects of caffeine deprivation rathe...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000119192
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:The present study investigated the effects of rapid tryptophan depletion (RTD), and the ensuing reduction of central nervous system levels of serotonin (5-HT), upon reactive aggression in patients with attention deficit/hyperactivity disorder (ADHD). Furthermore, it was asked whether the relation between 5-H...
journal_title:Neuropsychobiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000112951
更新日期:2007-01-01 00:00:00
abstract::The systematic recording of spontaneous electrodermal activity (EDA) on 23 normal subjects during 5 15-min sessions and the self-rating of anxious and/or depressive moods (Q-sort forced choice) shows a positive linear relationship between spontaneous EDA and anxious mood despite a low covariation between those two var...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117616
更新日期:1978-01-01 00:00:00