Abstract:
:1,927 outpatients were included by 392 general practitioners in an open study in order to evaluate the safety of tianeptine in the ambulatory treatment of depression. The results of 1,858 depressed patients without melancholia and psychotic features, fulfilling DSM III criteria of Major Depressive Episode or Dysthymic Disorder, could be analysed. 1,458 patients completed the 3-month treatment period. The group treated with 37.5 mg/day of tianeptine showed improvement on the Montgomery-Asberg Depression Rating Scale. With regard to the clinical tolerance of tianeptine, somatic complaints were rarely reported and adverse events necessitating premature termination of treatment (4.8% of included patients) were without clinical severity. Cardiovascular, haematologic, hepatic and biochemical safety were verified. No signs of dependence and no specific withdrawal symptoms were found after discontinuation of treatment.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Guelfi JD,Dulcire C,Le Moine P,Tafani Adoi
10.1159/000118824keywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
140-8issue
3eissn
0302-282Xissn
1423-0224pii
118824journal_volume
25pub_type
杂志文章abstract:BACKGROUND/AIMS:Valproic acid or valproate (VA) is an anticonvulsant and mood-stabilizing drug primarily used in the treatment of epilepsy and bipolar disorder. Ziprasidone (ZPN) is an atypical antipsychotic drug used mainly for the treatment of schizophrenia. METHODS:This study is a part of our investigation on the c...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000327604
更新日期:2011-01-01 00:00:00
abstract::The analysis of the results obtained in different tests--sleep studies, cortical and hippocampal EEG activity, PGO-R spikes--in rats or in cats allows the characterization of different classes of drugs and to establish the relative efficacy of psychoactive drugs in these models. Moreover, the sequential spectral analy...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000117972
更新日期:1983-01-01 00:00:00
abstract::Tetrahydrobiopterin (BH(4)) is a vital cofactor maintaining availability of the amine neurotransmitters [dopamine (DA), noradrenaline (NA), and serotonin (5-HT)], regulating the synthesis of nitric oxide (NO) by nitric oxide synthase (NOS), and stimulating and modulating the glutamatergic system (directly and indirect...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000089002
更新日期:2005-01-01 00:00:00
abstract::The systematic recording of spontaneous electrodermal activity (EDA) on 23 normal subjects during 5 15-min sessions and the self-rating of anxious and/or depressive moods (Q-sort forced choice) shows a positive linear relationship between spontaneous EDA and anxious mood despite a low covariation between those two var...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117616
更新日期:1978-01-01 00:00:00
abstract::Substance P (SP) is a neuropeptide which is abundant in the periphery and the central nervous system, where it is colocalized with other neurotransmitters such as serotonin or dopamine. SP has been proposed to play a role in the regulation of pain including migraine and fibromyalgia, asthma, inflammatory bowel disease...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000049254
更新日期:2002-01-01 00:00:00
abstract::To evaluate the effect of the odor of incense on brain activity, electroencephalograms (EEGs) and event-related potentials (ERPs) in a push/wait paradigm were recorded in 10 healthy adults (aged 23-39 years) with normal olfactory function. EEG was recorded from 21 electrodes on the scalp, according to the Internationa...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000209859
更新日期:2009-01-01 00:00:00
abstract::Cephalosporins may induce nonconvulsive status epilepticus (NCSE), a potentially reversible condition. Despite the wide use of these antibiotics, there are only few reported cases, because this condition is probably underestimated. We report two new cases of NCSE occurring during treatment with cefepime and ceftazidim...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000077370
更新日期:2004-01-01 00:00:00
abstract::Diabetes mellitus can induce impairment in learning and memory. Cognitive and memory deficits are common in older adults and especially in those with diabetes. This is mainly because of hyperglycemia, oxidative stress, and vascular abnormalities. Coenzyme Q10 (CoQ10) can decrease oxidative stress, hyperglycemia, and i...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000495520
更新日期:2019-01-01 00:00:00
abstract::The region coding human leukocyte antigen (HLA) on chromosome 6q21 was shown to be associated with both the vulnerability to schizophrenia and presence of eye movement disturbances (EMD). The aim of this preliminary study was to investigate how individual class I and II HLA antigens in schizophrenic patients may be re...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000085595
更新日期:2005-01-01 00:00:00
abstract::Spontaneous and drug-induced locomotor behavior was investigated in rats subjected to lesions of the ventral striatum, using the neurotoxin 6-hydroxydopamine to produce selective depletions of dopamine. Locomotor activity changed with time after lesion. At 2 weeks postoperative less spontaneous rearings were observed ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118311
更新日期:1986-01-01 00:00:00
abstract::It is known that P-4502E1 metabolizes both ethanol and acetaldehyde, and that it can be induced after birth by inducers such as ethanol. Genetic polymorphisms in the 5'-flanking region change its transcriptional regulation. Persons who are either hetereozygous or mutant homozygous for CYP2E1 (C1/C2 or C2/C2) can drink...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000070014
更新日期:2003-01-01 00:00:00
abstract::Based on 5-HT hypothesis, L-5-HTP (150 or 300 mg/day) was given orally to 18 depressed patients. The global estimates were 2 very much improved; 8 much improved; 3 minimally improved, and 5 unchanged. The action of L-5-HTP was usually rapid. The elevation of the serum 5-HT level 1 week after L-5-HTP administration was...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117687
更新日期:1979-01-01 00:00:00
abstract::Apomorphine, a dopamine receptor agonist (given in a dose of 0.75 mg s.c.), was administered to 8 healthy volunteers; electroencephalograph (EEG) and event-related potential (ERP) mapping were performed before dosing and 0.5, 1.5 and 2.5 h after dosing. Apomorphine caused an overall increase in beta activity at time 0...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000026560
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Disgust is a basic emotion that involves feelings of revulsion and withdrawal behavior from dangerous/infectious situations. Very little is known about the genetic basis of disgust sensitivity. The dopamine receptor D4 (DRD4) and catechol-O-methyltransferase (COMT) genes have been implicated in neuroticism-r...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000275822
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Self-immolation (SI) is considered one of the most painful, dramatic, and at the same time most inexplicable methods of suicide, with a high social impact. Prevalence rates are particularly high in Iran, and in north-western Iran specifically. Here, we report sociodemographic, psychological, and psychiatric ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000487859
更新日期:2017-01-01 00:00:00
abstract::The possible involvement of anxiety and learning/memory processes in escape-directed (struggling) behavior in a two-trial swimming test was investigated in mice, as well as the differential effects that low doses of flumazenil (a benzodiazepine receptor antagonist) could display depending on the animals' anxiety level...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119058
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:The failure to inhibit pleasurable but inappropriate urges is associated with frontal lobe pathology and has been suggested as a possible cause of pedophilic behavior. However, imaging and neuropsychological findings about frontal pathology in pedophilia are heterogeneous. In our study we therefore address i...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000355295
更新日期:2013-01-01 00:00:00
abstract::It has been 60 years since Cade first described patients who responded to antimanic lithium treatment. Two decades later, responders to lithium stabilization emerged in larger numbers. The responses of many severely ill bipolar patients to lithium were striking and called for an explanation. Remarkable reactions to a ...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000314305
更新日期:2010-01-01 00:00:00
abstract::A sample of schizophrenic inpatients and a control sample of normal volunteers, matched for age and sex were tested on two tasks before and after an exposure condition in which they pointed repeatedly to a target while viewing their hands and the target through prisms. Both groups showed significant changes in both ta...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117753
更新日期:1980-01-01 00:00:00
abstract::The usual method for extracting evoked potentials from EEG, the so-called averaging, is based on the hypothesis of the stationarity of the single responses in every EEG segment. Therefore, the possible variability of the single responses cannot be regarded. In this paper, a method for estimating single evoked response...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118112
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:So-called Porteus mazes are used to investigate prefrontal cortex (PFC) functioning in normal subjects and patients with different neuropsychiatric disorders. Here we present data confirming the involvement of the PFC for the first time by means of functional magnetic resonance imaging (fMRI). To minimize mo...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000095742
更新日期:2006-01-01 00:00:00
abstract::Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine and these neurotransmitters are hypothesized to be involved in the cognitive function of humans. This study of a cohort of 191 healthy young Chinese females attempts to utilize the intelligence qu...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000086609
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Executive functions (EF) are often impaired in autism spectrum disorder (ASD). Such dysfunctions are associated with anxiety, depression, and a lack of autonomy. Transcranial direct current stimulation (tDCS) has been shown to enhance EF in healthy adults and clinical populations and to improve working memor...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000501025
更新日期:2019-01-01 00:00:00
abstract::Two preliminary studies have indicated a variation in season of birth in severely language-disordered children. In the current study, the season of birth in 472 Danish children with language disorder born between 1958 and 1976 was compared with the season of birth of all Danish live-born children in the same period. F...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000084166
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Rasagiline and selegiline are classified as monoamine oxidase B (MAO-B) inhibitors. The present investigation deals with time-dependent electrical frequency changes (electropharmacograms) induced by these, as well as by aminoindan, the major metabolite of rasagiline. METHOD:Adult rats (day-night converted, ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000319947
更新日期:2010-01-01 00:00:00
abstract::In 63 depressed patients, the associations between severity of depression, psychomotor retardation, assessed by the Bech-Rafaelsen Melancholia Scale, and EEG spectral analysis were examined. Slow EEG activity (theta 2/alpha 1 bands) was positively and fast activity (alpha 3/beta bands) negatively correlated with the o...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118804
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVES:Corticotropin-releasing factor (CRF) plays a prominent role in mediating the effect of stressors on the hypothalamic-pituitary-adrenal axis. In this study, we examined the effects of chronic administration of second-generation antipsychotic drug ziprasidone on CRF mRNA expression in the hypothalamic paravent...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000322288
更新日期:2011-01-01 00:00:00
abstract::Sleep apnea is the most common sleep-related breathing disorder characterized by repetitive episodes of hypoxemia. Therapies include behavioral, surgical, orthodontic, pneumological, and pharmacological interventions. The aim of the present study was to compare the efficiency of pneumological therapy by nasal continuo...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000026575
更新日期:1999-01-01 00:00:00
abstract::The somnopolygraphs of 26 sober chronic alcoholics were compared with those of an age-matched control group, after approximately 25 days of sobriety. The sleep efficiency index and latency to sleep onset were significantly disturbed in alcoholic subjects. There was a decrease in the number of REM episodes. Slow-wave s...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118169
更新日期:1985-01-01 00:00:00
abstract::Intermittent short-lived episodes of depression were examined in a group of 20 recurrent suicidal attempters without major depression, classified misleadingly as borderline personality disorders on DSM-IIIR, during careful prospective follow-up for between 4 and 6 months. The duration of depressions clustered tightly ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118606
更新日期:1989-01-01 00:00:00