Abstract:
BACKGROUND:So-called Porteus mazes are used to investigate prefrontal cortex (PFC) functioning in normal subjects and patients with different neuropsychiatric disorders. Here we present data confirming the involvement of the PFC for the first time by means of functional magnetic resonance imaging (fMRI). To minimize motor-related activation, mental mazes were used. METHODS:Mazes as well as pseudo-mazes without any bifurcations were presented to 49 healthy participants during fMRI scans. RESULTS:Both, mazes as well as pseudo-mazes, activated a large network from visual to parietal regions, reflecting the dorsal stream of visual information processing. Mazes but not pseudo-mazes also activated bilateral areas of the PFC indicating their special role in decision processes. In addition, although no motor response was required during maze performance, both tasks activated subcortical and cortical motor areas. CONCLUSIONS:These tasks are suitable for investigating and specifying PFC functioning and its impairment in psychiatric disorders such as schizophrenia. In addition, mental mazes might be a suitable task for the investigation of patients with motor disturbances.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Kirsch P,Lis S,Esslinger C,Gruppe H,Danos P,Broll J,Wiltink J,Gallhofer Bdoi
10.1159/000095742subject
Has Abstractpub_date
2006-01-01 00:00:00pages
51-8issue
1eissn
0302-282Xissn
1423-0224pii
95742journal_volume
54pub_type
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