Brain activation during mental maze solving.

Abstract:

BACKGROUND:So-called Porteus mazes are used to investigate prefrontal cortex (PFC) functioning in normal subjects and patients with different neuropsychiatric disorders. Here we present data confirming the involvement of the PFC for the first time by means of functional magnetic resonance imaging (fMRI). To minimize motor-related activation, mental mazes were used. METHODS:Mazes as well as pseudo-mazes without any bifurcations were presented to 49 healthy participants during fMRI scans. RESULTS:Both, mazes as well as pseudo-mazes, activated a large network from visual to parietal regions, reflecting the dorsal stream of visual information processing. Mazes but not pseudo-mazes also activated bilateral areas of the PFC indicating their special role in decision processes. In addition, although no motor response was required during maze performance, both tasks activated subcortical and cortical motor areas. CONCLUSIONS:These tasks are suitable for investigating and specifying PFC functioning and its impairment in psychiatric disorders such as schizophrenia. In addition, mental mazes might be a suitable task for the investigation of patients with motor disturbances.

journal_name

Neuropsychobiology

journal_title

Neuropsychobiology

authors

Kirsch P,Lis S,Esslinger C,Gruppe H,Danos P,Broll J,Wiltink J,Gallhofer B

doi

10.1159/000095742

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

51-8

issue

1

eissn

0302-282X

issn

1423-0224

pii

95742

journal_volume

54

pub_type

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