Effects of electroconvulsive therapy on frontal white matter in late-life depression: a diffusion tensor imaging study.

Abstract:

:This study was conducted to elucidate the effects of electroconvulsive therapy (ECT) on frontal white matter in late-life depressed patients. Diffusion tensor imaging was performed on 8 late-life depressed patients and 12 healthy age-matched controls. The patients were scanned before and after a course of ECT. Fractional anisotropy (FA) was determined in the frontal and temporal regions and the corpus callosum. A significant white matter FA reduction was found in widespread frontal and temporal brain regions in patients with depression before ECT treatment compared with controls. A significant increase in frontal white matter FA was seen following ECT treatment. A course of bilateral ECT ameliorated white matter integrity in frontal brain regions. This suggests a strong relationship with the antidepressant action of ECT.

journal_name

Neuropsychobiology

journal_title

Neuropsychobiology

authors

Nobuhara K,Okugawa G,Minami T,Takase K,Yoshida T,Yagyu T,Tajika A,Sugimoto T,Tamagaki C,Ikeda K,Sawada S,Kinoshita T

doi

10.1159/000077941

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

48-53

issue

1

eissn

0302-282X

issn

1423-0224

pii

77941

journal_volume

50

pub_type

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