Periodic motor impairments in a case of 48-hour bipolar ultrarapid cycling before and under treatment with valproate.

Abstract:

:Motor impairments of psychiatric patients can be assessed with digital recordings of handwriting tasks. The investigation of patients with bipolar affective disorders differentiates intraindividual changes related to the patient's fluctuating affective states. An unmedicated 67-year-old male with 48-hour bipolar ultrarapid cycling was investigated during 8 consecutive days of ultrarapid cycling and 4 weeks later, after remission under treatment with valproate. The handwriting skills of the patient followed the same rhythmic changes of the psychopathology in the first part of the study and a steady pattern in the second phase, after remission. Therefore, it can be assumed that the handwriting skills reflect a state marker of the disease. Poorer handwriting skills on the manic days, as compared to the depressive ones, support the hypothesis of a low arousal in manic patients.

journal_name

Neuropsychobiology

journal_title

Neuropsychobiology

authors

Tigges P,Juckel G,Schröter A,Möller HJ,Hegerl U

doi

10.1159/000054851

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

38-42

eissn

0302-282X

issn

1423-0224

pii

54851

journal_volume

42 Suppl 1

pub_type

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