Abstract:
OBJECTIVE:A growing number of studies indicate increased impulsivity in patients with opioid dependence (OD). However, few studies exclude concomitant drug use and consider depression as a comorbidity, both of which can bias results. AIM:We aimed to compare impulsivity in patients with OD enrolled in maintenance therapy (ICD code F11.22) and well-matched healthy controls taking psychopathological impairments into account. Furthermore, we compared the result to risky behavioral patterns in patients. METHODS:This cross-sectional study included 50 patients with OD enrolled in either methadone or buprenorphine maintenance therapy and 50 healthy controls matched for gender, age, education, marital status, and premorbid intelligence. Abstinence from benzodiazepines, amphetamines, and cocaine was verified by urine analysis. We used the Barratt Impulsiveness Scale 11 (BIS-11), Beck's Depression Inventory (BDI), the Symptom Checklist 90 Revised (SCL-90R), and the European version of the Addiction Severity Index (EuropASI). RESULTS:Patients exhibited significantly worse impulse control than healthy individuals. We found no correlation between impulsiveness and reported risky behavior patterns but found a significant correlation between depressive symptoms and psychopathological impairment. CONCLUSIONS:Patients with OD showed a higher impulsivity than healthy individuals. Impulsivity could be a cause or a consequence of a substance use disorder; further research is warranted to explain this relationship. Impulsivity was associated with depression, an important confounder; future research needs to take this into account.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Peters L,Soyka Mdoi
10.1159/000494697subject
Has Abstractpub_date
2019-01-01 00:00:00pages
73-82issue
2eissn
0302-282Xissn
1423-0224pii
000494697journal_volume
77pub_type
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journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000115783
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abstract::To examine volumetric abnormality, the caudate nucleus was measured in patients with schizophrenia and healthy subjects using magnetic resonance imaging. The absolute and relative volumes of white matter in the caudate nucleus were found to be significantly smaller in patients with schizophrenia compared to those in h...
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pub_type: 临床试验,杂志文章
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journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
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abstract::Male Wistar rats were able to drink water and different percentages of ethyl alcohol in a free-choice paradigm. Our results showed a clear-cut preference for 2 and 3% ethanol concentration. Addition of quinine in both drinking bottles increased preference for alcohol, while dilution of saccharin in both bottles totall...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118113
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journal_title:Neuropsychobiology
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doi:10.1159/000118131
更新日期:1984-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000098265
更新日期:2006-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000026514
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journal_title:Neuropsychobiology
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doi:10.1159/000119178
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000337739
更新日期:2012-01-01 00:00:00
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journal_title:Neuropsychobiology
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doi:10.1159/000117483
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doi:10.1159/000182889
更新日期:2008-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000071212
更新日期:2003-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000362242
更新日期:2014-01-01 00:00:00
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pub_type: 历史文章,杂志文章,评审
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119243
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1994-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1988-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
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更新日期:2010-08-01 00:00:00
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更新日期:2001-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118093
更新日期:1984-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2010-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118914
更新日期:1992-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000353613
更新日期:2013-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1987-01-01 00:00:00