Long-term prognosis of patients with major depression and silent cerebral infarction.

Abstract:

OBJECTIVE:Many studies have examined the effects of cerebrovascular changes on treatment response in geriatric depression. However, few such studies have examined the relationship between cerebrovascular changes and long-term prognosis. We examined the effects of cerebrovascular changes on the course of geriatric depressive symptoms, dementia rates, and mortality over a follow-up period of approximately 10 years. METHOD:Participants were 84 patients with major depression (age of onset over 50 years); patients suffering from strokes, neurological disorders, and other psychiatric disorders were excluded. Magnetic resonance imaging findings were used to classify all patients into silent cerebral infarction (SCI)-positive (n = 37) or SCI-negative groups (n = 47). Prognoses were ascertained using a review of clinical charts and mailed questionnaires. RESULTS:Only 5% of patients with SCI were able to maintain remission whereas 36% of patients without SCI were able to do so. Total duration of depressive episodes was significantly longer in the SCI-positive group than in the SCI-negative group. SCI was also associated with a higher risk of dementia. CONCLUSION:The results of this long-term follow-up study demonstrate that the presence of SCI is associated with a relatively poor prognosis in geriatric depression.

journal_name

Neuropsychobiology

journal_title

Neuropsychobiology

authors

Yamashita H,Fujikawa T,Takami H,Yanai I,Okamoto Y,Morinobu S,Yamawaki S

doi

10.1159/000319359

subject

Has Abstract

pub_date

2010-08-01 00:00:00

pages

177-81

issue

3

eissn

0302-282X

issn

1423-0224

pii

000319359

journal_volume

62

pub_type

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