The control of blepharospasm by essential fatty acids.

Abstract:

:Dopamine depletion induced by administration of Ro4-1284 produces a condition of rapid and repeated eye blinking in rats. This condition mimics the human disorder, blepharospasm, which often accompanies parkinsonism and other dopamine deficiency disorders. When given a 3-week course of a compound (SR-3) developed from a specific ratio of two free polyunsaturated fatty acids - linoleic acid and alpha-linolenic acid - the eye blinking rate following administration of Ro4-1284 is reduced to saline and no drug control levels. These results suggest a favorable prospect for essential fatty acids in general, and SR-3 in particular, to provide an improved therapeutic option for the clinical management of benign essential blepharospasm.

journal_name

Neuropsychobiology

journal_title

Neuropsychobiology

authors

Mostofsky DI,Yehuda S,Rabinovitz S,Carasso R

doi

10.1159/000026648

keywords:

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

154-7

issue

3

eissn

0302-282X

issn

1423-0224

pii

26648

journal_volume

41

pub_type

杂志文章
  • Nonconvulsive status epilepticus during cephalosporin therapy.

    abstract::Cephalosporins may induce nonconvulsive status epilepticus (NCSE), a potentially reversible condition. Despite the wide use of these antibiotics, there are only few reported cases, because this condition is probably underestimated. We report two new cases of NCSE occurring during treatment with cefepime and ceftazidim...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000077370

    authors: Primavera A,Cocito L,Audenino D

    更新日期:2004-01-01 00:00:00

  • Relationship between alcoholism and CYP2E1 C/D polymorphism.

    abstract::The genotypes of the CYP2E1 loci of 35 alcoholic and 130 nonalcoholic (healthy controls) Japanese were investigated to determine the relationship between CYP2E1 (C/D) polymorphism and susceptibility to alcohol dependence. There was a significant (d.f. = 1, chi2 = 11.0, p < 0.001) difference in the CYP2E1 C gene freque...

    journal_title:Neuropsychobiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000026544

    authors: Iwahashi K,Ameno S,Ameno K,Okada N,Kinoshita H,Sakae Y,Nakamura K,Watanabe M,Ijiri I,Harada S

    更新日期:1998-11-01 00:00:00

  • Transcallosal inhibition in patients with and without alexithymia.

    abstract:OBJECTIVE:Previous results indicated a facilitated transcallosal inhibition via the corpus callosum (CC) in alexithymic male students. This study investigates transcallosal inhibition in alexithymic and nonalexithymic psychiatric inpatients. METHOD:Transcallosal inhibition was elicited by means of transcranial magneti...

    journal_title:Neuropsychobiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000092218

    authors: Richter J,Möller B,Spitzer C,Letzel S,Bartols S,Barnow S,Willert C,Freyberger HJ,Grabe HJ

    更新日期:2006-01-01 00:00:00

  • Abnormalities in behavior, learning ability, and the cholinergic system induced by long-term ultraviolet A irradiation of mice.

    abstract::Behavioral abnormalities, jumping reaction, increase in spontaneous activity abnormal violence, and lethargy were observed in long-term ultraviolet A (UVA)-irradiated hairy male Crj:CD-1 mice. The learning ability of 6- and 12-months UVA-irradiated mice was significantly reduced compared to un-irradiated age-matched m...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000119274

    authors: Hiramoto K,Okada T,Ito M

    更新日期:1996-01-01 00:00:00

  • Phosphatidylserine: quantitative EEG effects in healthy volunteers.

    abstract::Eight healthy paid male volunteers (age: 21-28 years, mean: 24.5 +/- 1.7 years; weight 62-79 kg) were administered via intravenous infusion (3 min) acute 25-, 50-, and 75-mg doses of phosphatidylserine, or matching placebo in a latin-square design. Multichannel EEG recordings were performed in baseline conditions, dur...

    journal_title:Neuropsychobiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000119041

    authors: Rosadini G,Sannita WG,Nobili F,Cenacchi T

    更新日期:1990-01-01 00:00:00

  • Isolation-induced changes in ultrasonic vocalization, fear-potentiated startle and prepulse inhibition in rats.

    abstract::Isolation causes important changes in the behavioral reactivity of rats to environmental stimuli. These changes include deficit in sensorimotor gating and altered fear-like responses to aversive stimuli. Measures of ultrasound vocalizations at 20-22 kHz when rats are exposed to threatening conditions, such as novelty,...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000085820

    authors: Nunes Mamede Rosa ML,Nobre MJ,Ribeiro Oliveira A,Brandão ML

    更新日期:2005-01-01 00:00:00

  • Premorbid personality traits and psychosomatic background factors in depression: the Lundby Study 1957-1972.

    abstract::The search for specific predepressive personality factors has a long tradition in psychiatry. Studies in which assessments were made prospectively, before the onset of a first-ever episode of the illness, are, however, rare. In the present report from the Lundby Study we have investigated premorbid, mainly personality...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118956

    authors: Rorsman B,Gräsbeck A,Hagnell O,Isberg PE,Otterbeck L

    更新日期:1993-01-01 00:00:00

  • The cholinergic basis of the smoking-induced EEG activation profile.

    abstract::Acute quantitative electroencephalographic effects of cigarette smoking were examined in 15 smokers within a repeated-measures design which assessed changes in power-spectral estimates following acute pre-treatment with placebo, a dose (20 mg) of mecamylamine, a dose (0.6 mg) of scopolamine and a combined dose of meca...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000026524

    authors: Knott VJ,Harr A,Ilivitsky V,Mahoney C

    更新日期:1998-01-01 00:00:00

  • Behavior-dependent and drug-induced changes of rat visual evoked potential: relation to the EEG spectral power.

    abstract::The relation between EEG spectral power and alterations of the visual evoked potential (VEP) during different behavioral states and after intraperitoneal application of neuroactive drugs have been investigated in Long-Evans rats. FFT power and field potential maps were made in five behavioral states of the unrestraine...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000119178

    authors: Bringmann A,Klingberg F

    更新日期:1995-01-01 00:00:00

  • Calcium-channel-blocking agent in the treatment of acute alcohol withdrawal--caroverine versus meprobamate in a randomized double-blind study.

    abstract::We present a randomized double-blind study on the efficacy of caroverine in the treatment of alcohol withdrawal symptoms. The group B Ca2+ channel blocking agent caroverine was tested against meprobamate in inpatient treatment of alcohol withdrawal. Patients of both groups were similar in age, weight, duration of drin...

    journal_title:Neuropsychobiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000118340

    authors: Koppi S,Eberhardt G,Haller R,König P

    更新日期:1987-01-01 00:00:00

  • The acute salivary ghrelin response to a psychosocial stress is enhanced in symptomatic patients with bulimia nervosa: a pilot study.

    abstract:BACKGROUND:Stress is a precipitating factor for both binge eating and bulimia nervosa (BN); however, the biological mechanisms through which it may trigger binge eating are poorly understood. There is evidence that the adrenal hormone cortisol and the gastric peptide ghrelin might be involved in stress-induced food ing...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000341877

    authors: Monteleone P,Tortorella A,Scognamiglio P,Serino I,Monteleone AM,Maj M

    更新日期:2012-01-01 00:00:00

  • Evolution of blood magnesium, sodium and potassium in depressed patients followed for three months.

    abstract::No consensus has been obtained about blood electrolyte status, especially about magnesium, in affective disorders. This is mainly due to the lack of information about the distribution of the patients in clinical subgroups, sex, type of treatment and about the severity of their illnesses. Most of these studies concerne...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118914

    authors: Widmer J,Bovier P,Karege F,Raffin Y,Hilleret H,Gaillard JM,Tissot R

    更新日期:1992-01-01 00:00:00

  • Late auditory evoked potentials: a method for monitoring drug effects on the central nervous system.

    abstract::An auditory event-related potential paradigm was designed to objectively quantify the effects of drugs on the central nervous system (CNS). A series of tones was presented at three random interstimulus intervals (ISI). The amplitude of N1-P2 and the recovery of this complex across ISI appear to be rapid, reliable and ...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118715

    authors: Noldy NE,Neiman J,el-Nesr B,Carlen PL

    更新日期:1990-01-01 00:00:00

  • Long-term outcome after lithium augmentation in unipolar depression: focus on HPA system activity.

    abstract:BACKGROUND:Lithium augmentation is a first-line strategy for depressed patients resistant to antidepressive therapy, but little is known about patients' subsequent long-term course or outcome predictors. We investigated long-term outcomes of unipolar depressed patients who had participated in a study on the effects of ...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000234814

    authors: Adli M,Bschor T,Bauer M,Lucka C,Lewitzka U,Ising M,Uhr M,Mueller-Oerlinghausen B,Baethge C

    更新日期:2009-01-01 00:00:00

  • Computerized topo-EEG spectral maps: difficulties and perspectives.

    abstract::An electric potential measurement tells us only about the difference between two electrode locations. When prior experiments or present measurements prove that an electrode's location is inactive (especially in 'mono-polar' or scalp-to-reference technique), then EEG records and EEG maps can be interpreted regionally n...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118093

    authors: Walter DO,Etevenon P,Pidoux B,Tortrat D,Guillou S

    更新日期:1984-01-01 00:00:00

  • Recent developments in an animal model of visual evoked potential augmenting/reducing and sensation seeking behavior.

    abstract::The early research on an animal (cat) model and biological marker (visual evoked potential augmenting and reducing) of sensation seeking behavior is briefly described. Recent findings with selectively bred lines of rats show that (1) the relationship between sensation seeking behavior and augmenting vs. reducing is al...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章,评审

    doi:10.1159/000119304

    authors: Siegel J,Driscoll P

    更新日期:1996-01-01 00:00:00

  • Efficacy of trazodone as an anti-obsessional agent.

    abstract::Eight patients with chronic obsessive-compulsive neurosis were subjected to trazodone, an antidepressant acting on the serotonergic system. After 4 weeks of treatment, 6 showed significant reduction in the obsessional symptoms which was sustained after a 6-week follow-up. The 2 patients who did not show improvement ha...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118274

    authors: Prasad A

    更新日期:1986-01-01 00:00:00

  • Different effects of cholestyramine on postprandial secretions of cholecystokinin and peptide YY in women with bulimia nervosa.

    abstract:OBJECTIVE:Patients with bulimia nervosa (BN) are reported to have decreased postprandial levels of cholecystokinin (CCK) and peptide YY (PYY). Fatty nutrients are the most powerful stimulus for releasing these peptides. Cholestyramine is an anion exchanger which adsorbs bile salts and reduces the digestion of lipids, a...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000368160

    authors: Rigamonti AE,Sartorio A,Scognamiglio P,Bini S,Monteleone AM,Mastromo D,Marazzi N,Cella SG,Monteleone P

    更新日期:2014-01-01 00:00:00

  • Cortical blood flow and negative symptoms in schizophrenia.

    abstract::An association between negative symptoms and frontal cortex abnormalities has been suggested in schizophrenic patients. We tested whether this association can be found when patients' task performance is good and while controlling for possible cortical atrophy. We investigated regional cerebral blood flow with the xeno...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000119262

    authors: Zemishlany Z,Alexander GE,Prohovnik I,Goldman RG,Mukherjee S,Sackeim H

    更新日期:1996-01-01 00:00:00

  • Depression-inducing and antidepressive effects of neuroleptics. Experiences with flupenthixol and flupenthixol decanoate.

    abstract::The antidepressive and anxiolytic efficacy of flupenthixol has been investigated in numerous controlled and open trials involving patients with endogenous, reactive as well as senile depressions. When administered at a mean daily single or multiple dose of 1-2 mg, flupenthixol proved to be a very effective and well-to...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000117999

    authors: Pöldinger W,Sieberns S

    更新日期:1983-01-01 00:00:00

  • Differential Effects of Electroconvulsive Therapy in the Treatment of Major Depressive Disorder.

    abstract:BACKGROUND/AIMS/METHODS:Electroconvulsive therapy (ECT) is still one of the most potent treatments in the acute phase of major depressive disorder (MDD) and particularly applied in patients considered treatment resistant. However, despite the frequent and widespread use of ECT for >70 years, the exact neurobiological m...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章,评审

    doi:10.1159/000505553

    authors: Stippl A,Kirkgöze FN,Bajbouj M,Grimm S

    更新日期:2020-01-01 00:00:00

  • Symptom dimensions of schizophrenia: a selective integration of neurophysiological and neuropsychological correlates.

    abstract::Schizophrenia is a heterogeneous and multidimensional disorder. The different syndromes or dimensions of this disorder represent distinct pathophysiological processes. Evidence is growing that each of the composite syndromes or dimensions of this disorder is associated with specific validators. This article reviewed n...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章,评审

    doi:10.1159/000119310

    authors: Aderibigbe YA,Gureje O

    更新日期:1996-01-01 00:00:00

  • Plasma 3,4-dihydroxyphenylethyleneglycol and therapeutic response to maprotiline and indalpine in major depression.

    abstract::Plasma levels of free and conjugated 3,4-dihydroxyphenylethyleneglycol (DOPEG), the main deaminated metabolite of norepinephrine, were assayed in 48 depressed patients before initiating a treatment with either maprotiline, an inhibitor of norepinephrine reuptake, or indalpine, a specific inhibitor of serotonin reuptak...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118243

    authors: Lôo H,Benkelfat C,Poirier MF,Vanelle JM,Olié JP,Dennis T,Scatton B

    更新日期:1986-01-01 00:00:00

  • Chronic, but not acute, clomipramine or fluoxetine treatment reduces the spontaneous firing rate in the mesoaccumbens neurons of the rat.

    abstract::In the present study, single-unit extracellular recording was used in male Wistar rats to compare the effects of a single dose (acute treatment) and a 21-day regimen (long-term treatment) with clomipramine (2.5 mg/kg) and fluoxetine (1.0 mg/kg) on the spontaneous firing rate of nucleus accumbens (NAcc) neurons connect...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000073627

    authors: Rodríguez-Landa JF,Contreras CM,Gutiérrez-García AG,Bernal-Morales B

    更新日期:2003-01-01 00:00:00

  • Correlation between platelet alpha(2)-adrenoreceptors and symptom severity in major depression.

    abstract:BACKGROUND:Abnormalities in different parameters of the norepinephrine system have been widely described in major depression. The presence of alpha(2)-adrenoreceptors in blood platelets, similar to those in the brain, prompted us to evaluate them in depressed patients, as compared with healthy controls. METHODS:Fiftee...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000054930

    authors: Marazziti D,Baroni S,Masala I,Di Nasso E,Giannaccini G,Betti L,Lucacchini A,Cassano GB

    更新日期:2001-01-01 00:00:00

  • Urinary brain-derived neurotrophic factor as a biomarker of executive functioning.

    abstract:BACKGROUND/AIMS:Neurotrophins such as brain-derived neurotrophic factor (BDNF) are vital for neuronal survival and adaptive plasticity. With high BDNF gene expression in the prefrontal cortex, BDNF is a potential regulatory factor for building and maintaining cognitive reserves. Recent studies suggest that individual d...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000362242

    authors: Koven NS,Collins LR

    更新日期:2014-01-01 00:00:00

  • Effects of electroconvulsive therapy on frontal white matter in late-life depression: a diffusion tensor imaging study.

    abstract::This study was conducted to elucidate the effects of electroconvulsive therapy (ECT) on frontal white matter in late-life depressed patients. Diffusion tensor imaging was performed on 8 late-life depressed patients and 12 healthy age-matched controls. The patients were scanned before and after a course of ECT. Fractio...

    journal_title:Neuropsychobiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000077941

    authors: Nobuhara K,Okugawa G,Minami T,Takase K,Yoshida T,Yagyu T,Tajika A,Sugimoto T,Tamagaki C,Ikeda K,Sawada S,Kinoshita T

    更新日期:2004-01-01 00:00:00

  • Relationship between class I and II HLA antigens in schizophrenia and eye movement disturbances: a preliminary study.

    abstract::The region coding human leukocyte antigen (HLA) on chromosome 6q21 was shown to be associated with both the vulnerability to schizophrenia and presence of eye movement disturbances (EMD). The aim of this preliminary study was to investigate how individual class I and II HLA antigens in schizophrenic patients may be re...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000085595

    authors: Bogacki PA,Borkowska A,Wojtanowska-Bogacka M,Rybakowski JK

    更新日期:2005-01-01 00:00:00

  • Serotonin transporter bi- and triallelic genotypes and their relationship with anxiety and academic performance: a preliminary study.

    abstract:BACKGROUND:Considerable evidence suggests that variation of the serotonin-transporter-linked promoter region (5- HTTLPR) is associated with anxiety-related traits. Academic outcomes are also more closely related to trait anxiety. This preliminary study aimed to explore the association between academic performance and l...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000317550

    authors: Calapoğlu M,Sahin-Calapoğlu N,Karaçöp A,Soyöz M,Elyıldırım UY,Avşaroğlu S

    更新日期:2011-01-01 00:00:00

  • Social factors but not stress-coping styles predict relapse in detoxified alcoholics.

    abstract::Alcohol-dependent patients face a substantial risk of relapse after detoxification. Though psychosocial stress and coping strategies are regarded as major contributing factors in returning to drinking, the direct effects of coping styles on relapse are not clear. In this treatment outcome study, a mixed gender sample ...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000096991

    authors: Walter M,Gerhard U,Duersteler-MacFarland KM,Weijers HG,Boening J,Wiesbeck GA

    更新日期:2006-01-01 00:00:00