Abstract:
:The search for specific predepressive personality factors has a long tradition in psychiatry. Studies in which assessments were made prospectively, before the onset of a first-ever episode of the illness, are, however, rare. In the present report from the Lundby Study we have investigated premorbid, mainly personality-related background factors for first incidences of depressive disorder, diagnosed according to the Lundby criteria for 'Depression proper' and 'Depression plus other psychiatric symptoms'. The items found to be of a predictive value differed between the two diagnostic subgroups and also between men and women. The findings are discussed and compared with earlier predictor studies on depression.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Rorsman B,Gräsbeck A,Hagnell O,Isberg PE,Otterbeck Ldoi
10.1159/000118956subject
Has Abstractpub_date
1993-01-01 00:00:00pages
72-9issue
2eissn
0302-282Xissn
1423-0224pii
118956journal_volume
27pub_type
杂志文章abstract:BACKGROUND:There is increasing evidence that altered immune responses play a role in the pathogenesis of autism spectrum disorders (ASD), together with dysfunction of the serotonergic and glutamatergic systems. Since the kynurenine (KYN) pathway that degrades tryptophan (TRP) is activated in various neuroinflammatory s...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000488157
更新日期:2017-01-01 00:00:00
abstract:AIM:We describe the difficulties encountered in making a diagnosis where a somatic condition manifests itself alongside psychiatric symptoms associated with possible psychiatric comorbidities. METHODS:A case study is presented of a 15-year-old girl who was eventually diagnosed with ornithine transcarbamylase (OTC) def...
journal_title:Neuropsychobiology
pub_type:
doi:10.1159/000508679
更新日期:2020-07-20 00:00:00
abstract::Nitric oxide (NO) has been implicated to play a role in the pathogenesis of depressive disorders. Adrenomedullin (AM) induces vasorelaxation by activating adenylate cyclase and also by stimulating the release of NO. AM immune reactivity is present in the brain, consistent with a role as neurotransmitter. Therefore, it...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000048677
更新日期:2002-01-01 00:00:00
abstract::77 primary depressive in-patients aged 18-70 years (mean = 46/47 years) were assigned randomly to experimental and control groups and treated in double-blind conditions in ten centers. Butriptyline and amitriptyline were both administered with an identical increasing schedule, up to 150 mg daily in the first week and ...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000117952
更新日期:1983-01-01 00:00:00
abstract::Isolation causes important changes in the behavioral reactivity of rats to environmental stimuli. These changes include deficit in sensorimotor gating and altered fear-like responses to aversive stimuli. Measures of ultrasound vocalizations at 20-22 kHz when rats are exposed to threatening conditions, such as novelty,...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000085820
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:The present study investigated the effects of rapid tryptophan depletion (RTD), and the ensuing reduction of central nervous system levels of serotonin (5-HT), upon reactive aggression in patients with attention deficit/hyperactivity disorder (ADHD). Furthermore, it was asked whether the relation between 5-H...
journal_title:Neuropsychobiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000112951
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND AND AIM:Repetitive transcranial magnetic stimulation (rTMS) is supposed to be not as effective in severe depression as it is in medium depression. We evaluated the treatment response to an ultra-high-frequency (UHF; 30 Hz) approach, which was used to maximize the rTMS efficacy in severely ill patients. METH...
journal_title:Neuropsychobiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000339561
更新日期:2012-01-01 00:00:00
abstract::Diabetes mellitus can induce impairment in learning and memory. Cognitive and memory deficits are common in older adults and especially in those with diabetes. This is mainly because of hyperglycemia, oxidative stress, and vascular abnormalities. Coenzyme Q10 (CoQ10) can decrease oxidative stress, hyperglycemia, and i...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000495520
更新日期:2019-01-01 00:00:00
abstract::A double-blind comparison of zimeldine, a selective 5-HT reuptake inhibitor, and nomifensine, a noradrenaline and a dopamine reuptake inhibitor, was carried out in 43 inpatients with a scheduled treatment period of 6 weeks. All patients were diagnosed as definite major depressive disorder according to Research Diagnos...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000118086
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Depressive disorder (DD) is characterized by an inflammatory process and oxidative stress. Cyclooxygenase-2 (COX-2), the expression of which increases in depression, is an enzyme involved in inflammation and free radical processes. The aim of our study was to assess the correlation between single nucleotide ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000317284
更新日期:2010-01-01 00:00:00
abstract::Quantitative pharmaco-EEG has become a useful technique for determining pharmacodynamic parameters after CNS-active drug administration. Nevertheless, one of the most important problems faced by practitioners of pharmaco-EEG is the difficulty in evaluating drug-specific effects. In this article, a methodology for comp...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119068
更新日期:1994-01-01 00:00:00
abstract::It has been 60 years since Cade first described patients who responded to antimanic lithium treatment. Two decades later, responders to lithium stabilization emerged in larger numbers. The responses of many severely ill bipolar patients to lithium were striking and called for an explanation. Remarkable reactions to a ...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000314305
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Stress is a precipitating factor for both binge eating and bulimia nervosa (BN); however, the biological mechanisms through which it may trigger binge eating are poorly understood. There is evidence that the adrenal hormone cortisol and the gastric peptide ghrelin might be involved in stress-induced food ing...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000341877
更新日期:2012-01-01 00:00:00
abstract::In 63 depressed patients, the associations between severity of depression, psychomotor retardation, assessed by the Bech-Rafaelsen Melancholia Scale, and EEG spectral analysis were examined. Slow EEG activity (theta 2/alpha 1 bands) was positively and fast activity (alpha 3/beta bands) negatively correlated with the o...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118804
更新日期:1992-01-01 00:00:00
abstract::An auditory event-related potential paradigm was designed to objectively quantify the effects of drugs on the central nervous system (CNS). A series of tones was presented at three random interstimulus intervals (ISI). The amplitude of N1-P2 and the recovery of this complex across ISI appear to be rapid, reliable and ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118715
更新日期:1990-01-01 00:00:00
abstract::Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine and these neurotransmitters are hypothesized to be involved in the cognitive function of humans. This study of a cohort of 191 healthy young Chinese females attempts to utilize the intelligence qu...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000086609
更新日期:2005-01-01 00:00:00
abstract::Electrovestibulography (EVestG) recordings have been previously applied toward classifying and/or measuring the severity of several neurological disorders including depression with and without anxiety. This study's objectives were to: (1) extract EVestG features representing physiological differences of healthy women ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000487771
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND/AIMS:Previous functional neuroimaging studies have reported that patients with schizophrenia show reduced prefrontal activation during cognitive tasks whereas patients with schizotypal personality disorder (SPD) show preserved or even increased right prefrontal activation, compared to healthy controls; on th...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000129669
更新日期:2008-01-01 00:00:00
abstract::The medical histories of 600 psychotic and 369 nonpsychotic subjects were examined for the occurrence of rheumatic chorea. There was significantly more rheumatic chorea in the histories of psychotic patients than in nonpsychotics (p less than 0.01, chi-square). Neuropathological associations are discussed. ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118234
更新日期:1986-01-01 00:00:00
abstract::Plasma noradrenaline (NA), adrenaline (Ad), dopamine (DA), platelet serotonin (p5HT), free serotonin (f5HT), glucose, heart rate (HR) and blood pressure (BP) were measured before and after an oral load of glucose (OGTT) in 100 normal humans. One sham-feeding test was performed in every subject 2-3 weeks before OGTT. A...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118889
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:There is some evidence that repetitive transcranial magnetic stimulation (rTMS) is an effective method of treating patients suffering from obsessive-compulsive disorder (OCD). Here, we tested the hypothesis that rTMS has a positive impact both on symptom severity and cognitive performance in such patients. Sp...
journal_title:Neuropsychobiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000446287
更新日期:2016-01-01 00:00:00
abstract::The aim of this paper was to determine whether the prolonged decrease in seizure threshold produced by chemical kindling was accompanied by behavioural changes in tests of anxiety and aggression. The responses of rats in five tests were examined after chronic treatment with the benzodiazepine inverse agonist FG7142. T...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118460
更新日期:1988-01-01 00:00:00
abstract::Male Wistar rats were able to drink water and different percentages of ethyl alcohol in a free-choice paradigm. Our results showed a clear-cut preference for 2 and 3% ethanol concentration. Addition of quinine in both drinking bottles increased preference for alcohol, while dilution of saccharin in both bottles totall...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118113
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Lithium augmentation is a first-line strategy for depressed patients resistant to antidepressive therapy, but little is known about patients' subsequent long-term course or outcome predictors. We investigated long-term outcomes of unipolar depressed patients who had participated in a study on the effects of ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000234814
更新日期:2009-01-01 00:00:00
abstract::Neural-network pattern classifiers were used to study the effects of long half-life flurazepam (30 mg) and quazepam (15 mg), and short half-life triazolam (0.5 mg) on non-REM sleep. We measured the magnitude of effect, time course, and EEG spectral signature of the three benzodiazepines as a function of third-of-night...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118444
更新日期:1988-01-01 00:00:00
abstract::Cardiovascular measurements were used as indicators of autonomic arousal during an orthostatic challenge test without medication and after a test dose of 150 mg perazine in 20 acute schizophrenic patients. Unmedicated schizophrenics showed elevated heart rates and elevated systolic and diastolic blood pressure in comp...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000119144
更新日期:1994-01-01 00:00:00
abstract::The focus is on evaluating the relationships between early behavioural problems and biochemical variables at adult age and their significance for early criminality and violent behaviour in a life perspective. In the present study, using prospective longitudinal data, a sample of males with a history of early criminal ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000087557
更新日期:2005-01-01 00:00:00
abstract::The popular recreational drug, (+/-)3, 4-methylenedioxymethamphetamine (MDMA; 'Ecstasy') is a potent and selective brain serotonin (5-HT) neurotoxin in animals. MDMA-induced 5-HT neurotoxicity can be demonstrated using a variety of neurochemical, neuroanatomical and, more recently, functional measures of 5-HT neurons....
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000026664
更新日期:2000-01-01 00:00:00
abstract::Acute quantitative electroencephalographic effects of cigarette smoking were examined in 15 smokers within a repeated-measures design which assessed changes in power-spectral estimates following acute pre-treatment with placebo, a dose (20 mg) of mecamylamine, a dose (0.6 mg) of scopolamine and a combined dose of meca...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026524
更新日期:1998-01-01 00:00:00
abstract::Fengabine is a new GABAmimetic compound active in animal models predictive of antidepressant activity. The present overview reports the results of 6 double-blind trials versus tricyclics (TCAs) (3 in outpatients and 3 in inpatients). Overall, 398 adult patients (149 males and 249 females) were treated; 194 with fengab...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000118485
更新日期:1989-01-01 00:00:00