Abstract:
:The antidepressive and anxiolytic efficacy of flupenthixol has been investigated in numerous controlled and open trials involving patients with endogenous, reactive as well as senile depressions. When administered at a mean daily single or multiple dose of 1-2 mg, flupenthixol proved to be a very effective and well-tolerated antidepressant. As opposed to some of the currently available antidepressants, flupenthixol has a rapid onset of action which is often displayed within the first 2-3 days following its application. Flupenthixol decanoate has also a pronounced antidepressive and anxiolytic effect which appears to be adequate enough for treating mild to moderately severe syndromes of depression. This depot neuroleptic has been given at a fortnightly dosage ranging between 2.5 and 30 mg. However, if the aspect of efficacy in relation to tolerance has to be taken in to consideration, then 5 mg are apt to be an appropriate dose. Patients with an agitated depression and/or suicide ideation should, however, be excluded from therapy with this drug. Extrapyramidal movement disorders which may appear during treatment are a disadvantage of this medication. Apparently such disorders are rarely encountered if the dose is kept below 10 mg. Other untoward effects are very seldom indeed. A final and conclusive judgement on the possible application of flupenthixol decanoate in the prophylaxis of phases in patients with bipolar and periodical depressions is as yet not feasible. Further clinical trials are necessary before flupenthixol decanoate can be classified as a possible 'depot antidepressant'.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Pöldinger W,Sieberns Sdoi
10.1159/000117999subject
Has Abstractpub_date
1983-01-01 00:00:00pages
131-6issue
2-3eissn
0302-282Xissn
1423-0224journal_volume
10pub_type
杂志文章abstract::A 56-year-old male parkinsonian patient developed a unique behavioral change following the oral administration of cinepazide, a cerebral vasodilator. This behavior consisted of an apparent infatuation with a ward nurse, which ceased after medication was discontinued. ...
journal_title:Neuropsychobiology
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1996-01-01 00:00:00
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更新日期:2006-01-01 00:00:00
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更新日期:2001-01-01 00:00:00
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更新日期:2003-01-01 00:00:00
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更新日期:1980-01-01 00:00:00
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更新日期:1990-01-01 00:00:00
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更新日期:2017-01-01 00:00:00