Abstract:
:The focus is on evaluating the relationships between early behavioural problems and biochemical variables at adult age and their significance for early criminality and violent behaviour in a life perspective. In the present study, using prospective longitudinal data, a sample of males with a history of early criminal behaviour and male controls (n = 103) were investigated concerning (1) teacher-rated behaviours at age 11-14 years; (2) platelet monoamine oxidase (MAO) activity and tri-iodothyronine (T(3)) level at adult age; (3) registered early criminality (11-14 years); (4) records of violent offending up to age 35 years, and (5) interview data on smoking. The main finding was that a combined risk level pattern of low MAO activity and high T(3) level was found significantly more frequently than expected in violent offenders with an early behavioural risk pattern. Furthermore, there was a significant interaction effect between early attention difficulties and smoking on MAO activity, as well as an effect by smoking on MAO activity. The findings are discussed in terms of the possible influence of biological vulnerability to certain behaviours, which in combination with possible childhood stress, enhance the risk for antisocial behaviours and subsequent violence.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Eklund J,Alm PO,af Klinteberg Bdoi
10.1159/000087557keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
122-9issue
3eissn
0302-282Xissn
1423-0224pii
87557journal_volume
52pub_type
杂志文章abstract::We hypothesized that levels of N-acetyl-beta-glucosaminidase (NAG) would differ between patients making serious versus nonserious suicide attempts. The levels of NAG from 11 patients hospitalized for serious suicide attempts were compared to 5 patients whose suicide attempts were not rated serious. There was a signifi...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000026688
更新日期:2000-01-01 00:00:00
abstract::Twenty-seven medicated chronic schizophrenic female patients were tested for right or left turning behavior. No substantial right or left asymmetry was found, nor did the addition of the indirect dopaminergic agonist amantadine influence these results. Previous studies demonstrated left circling preference in chronic ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119355
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND/AIMS:Suicidal behavior (SB) in bipolar disorder (BD) is a complex multifactorial event resulting from an interaction of genetic, neurobiological and psychosocial factors. Recent studies identified new possible mechanisms, suggesting a role for sirtuins (SIRTs 1-7), a family of nicotinamide adenine dinucleoti...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000446921
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:The characterization of an individual's hypothalamic-pituitary-adrenal axis stress response is a main research topic in neuropsychobiology since alterations have been causally linked to several disease states. Over the last years, several studies focused on the identification of sources of inter- and intrain...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000115783
更新日期:2007-01-01 00:00:00
abstract::Possible age effects on binding of [(3)H]lysergic acid diethylamide ([(3)H]LSD) to serotonin 5-HT(2A) receptors and of [(3)H]paroxetine to serotonin uptake sites were studied in platelets from healthy children (11-12 years of age), adolescents (16-17 years of age) and adults. Significant overall age effects were found...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026617
更新日期:1999-11-01 00:00:00
abstract::The prevalence of an abnormal response to the 1 mg dexamethasone suppression test (DST) was examined in 40 inpatients suffering from a major depressive disorder (MDD), 17 inpatients suffering from schizophrenia, and 30 normal controls. 23.5% of the schizophrenics were DST nonsuppressors compared to 52.5% of MDD patien...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118252
更新日期:1986-01-01 00:00:00
abstract::This report presents the results of a retrospective analysis of pooled efficacy data from eight studies in which buspirone was compared to placebo in 520 patients with generalized anxiety disorder (GAD). In addition to evaluating overall efficacy in the composite patient data base, four criteria were used to identify ...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,meta分析,随机对照试验
doi:10.1159/000118837
更新日期:1992-01-01 00:00:00
abstract::Two preliminary studies have indicated a variation in season of birth in severely language-disordered children. In the current study, the season of birth in 472 Danish children with language disorder born between 1958 and 1976 was compared with the season of birth of all Danish live-born children in the same period. F...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000084166
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND/AIMS:Heschl's gyrus (HG) is functionally involved in the genesis of auditory verbal hallucinations (AVH). This dysfunction seems to be structurally facilitated. The aim of the study was to analyze macrostructural features of HG in a group of patients reporting AVH who demonstrated white matter diffusion tens...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000258637
更新日期:2010-01-01 00:00:00
abstract::We have previously shown that the tilt aftereffect (TAE) appears to respond to changes in central dopaminergic function. In this study, the TAE was investigated during the preovulatory and the premenstrual phases of the menstrual cycle. Results in the preovulatory phase mimicked those previously found associated with ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119484
更新日期:1990-01-01 00:00:00
abstract::The effects of two benzodiazepines (alprazolam and bromazepam) on performance and event-related brain potentials (ERPs) in visual search and verbal recognition memory paradigms were tested in a placebo-controlled double-blind paradigm employing 12 young healthy subjects. Both drugs exerted similar effects on performan...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000119291
更新日期:1996-01-01 00:00:00
abstract::Hallucinogenic drug-induced states are considered as models for acute schizophrenic disorders (experimental psychoses). In a double-blind study with healthy volunteers we investigated the influence of the serotonergic hallucinogen psilocybin, the ecstasy-like drug 3,4-methylenedioxyethylamphetamine (MDE), the stimulan...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000063672
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Disgust is a basic emotion that involves feelings of revulsion and withdrawal behavior from dangerous/infectious situations. Very little is known about the genetic basis of disgust sensitivity. The dopamine receptor D4 (DRD4) and catechol-O-methyltransferase (COMT) genes have been implicated in neuroticism-r...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000275822
更新日期:2010-01-01 00:00:00
abstract::Supine and standing heart rate (HR) and blood pressure measures were compared among 19 nonsmoking normal controls, 29 smoking patients and 36 nonsmoking patients with panic disorder. The smoking patients had a significantly higher supine HR, standing diastolic blood pressure, standing mean blood pressure and supine an...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119440
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Stress is a precipitating factor for both binge eating and bulimia nervosa (BN); however, the biological mechanisms through which it may trigger binge eating are poorly understood. There is evidence that the adrenal hormone cortisol and the gastric peptide ghrelin might be involved in stress-induced food ing...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000341877
更新日期:2012-01-01 00:00:00
abstract::The authors recorded contingent negative variation (CNV) in a group of subjects affected by presenile dementia, at the onset of the symptoms, with a slight degree of intellectual deterioration. Recordings were carried out in rest basal conditions and upon administration of an insignificant distracting stimulus. Result...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118121
更新日期:1984-01-01 00:00:00
abstract::Saliva cortisol was measured at 11 p.m. in a sample of 74 psychiatric inpatients composed of 24 primary endogenous depressives, 40 secondary depressives and 20 nondepressives (DSM III and Saint-Louis criteria). Primary depressives had significantly higher 11 p.m. saliva cortisol levels than nondepressives (p less than...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118384
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:Memory processes, as reflected by 'old/new' effects of event-related potentials (ERPs), have been shown to be impaired in depressed patients. This variability might be partly explained by biological factors. S100B is a glial calcium-binding protein with neuroplastic properties; S100B serum levels have been sh...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000219304
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Considerable evidence suggests that variation of the serotonin-transporter-linked promoter region (5- HTTLPR) is associated with anxiety-related traits. Academic outcomes are also more closely related to trait anxiety. This preliminary study aimed to explore the association between academic performance and l...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000317550
更新日期:2011-01-01 00:00:00
abstract::Premenstrual tension was studied in 16 females, using both biochemical and psychological parameters during the pre- and postmenstrual phases. Uptake of serotonin (5-HT) and the levels of 5-HT in platelet-rich plasma and platelet-poor plasmas were determined. Degrees of distress experienced pre- and postmenstrually wer...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118103
更新日期:1984-01-01 00:00:00
abstract::A 56-year-old male parkinsonian patient developed a unique behavioral change following the oral administration of cinepazide, a cerebral vasodilator. This behavior consisted of an apparent infatuation with a ward nurse, which ceased after medication was discontinued. ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118040
更新日期:1984-01-01 00:00:00
abstract::To clarify the circadian aspects of delayed sleep phase syndrome (DSPS) in 4 patients with DSPS, we recorded polysomnograms and rectal temperature before and after chronotherapy. The time interval (2.7 h) between sleep onset and rectal temperature minimum before chronotherapy was shorter than the time interval after c...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118495
更新日期:1988-01-01 00:00:00
abstract::In the present study, the effects of short-acting benzodiazepines on nocturnal sleep and the carryover effects of these drugs were studied. The study involved 10 young, healthy male subjects who had given their written informed consent to participate. Either a placebo (PLA), 0.125 mg triazolam (TRZ), 0.25 mg TRZ or 0....
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000070586
更新日期:2003-01-01 00:00:00
abstract::Tetrahydrobiopterin (BH(4)) is a vital cofactor maintaining availability of the amine neurotransmitters [dopamine (DA), noradrenaline (NA), and serotonin (5-HT)], regulating the synthesis of nitric oxide (NO) by nitric oxide synthase (NOS), and stimulating and modulating the glutamatergic system (directly and indirect...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000089002
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Schizophrenia is a genetically complex disorder with an unknown pathophysiology. Several genes implicated in glutamate metabolism have been associated with the disorder. Recent studies of polymorphisms in the dystrobrevin-binding protein 1 gene (DTNBP1; dysbindin) and D-amino-acid-oxidase (DAO) gene, both in...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000235799
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:There is increasing evidence that altered immune responses play a role in the pathogenesis of autism spectrum disorders (ASD), together with dysfunction of the serotonergic and glutamatergic systems. Since the kynurenine (KYN) pathway that degrades tryptophan (TRP) is activated in various neuroinflammatory s...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000488157
更新日期:2017-01-01 00:00:00
abstract::Changes of field potentials electrically evoked from the mesencephalon were studied in two dopaminergic target areas. The modulation of the responses in prefrontal cortex and striatum induced by intravenous injection of various compounds influencing central dopaminergic transmission is followed. In general, drugs with...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118200
更新日期:1985-01-01 00:00:00
abstract::Growth hormone (GH) possesses multiple metabolic effects, in particular with regard to glucose and lipid homeostasis. Studies on the effects of GH on body weight and food and water intake are scarce and have yielded controversial results. We investigated the effects of different modes of GH administration on the param...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000048671
更新日期:2002-01-01 00:00:00
abstract::The soporific effect of the neuroactive steroid pregnanolone, a metabolite of progesterone, and its relationship with plasma concentrations was assessed in 18 young, healthy, male volunteers for 2 h after administration of a single dose of pregnanolone prepared in two different formulations. Sedation was measured as s...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000119300
更新日期:1996-01-01 00:00:00
abstract::The effects of zolpidem or zaleplon on sleep architecture, respiratory patterns and performance were assessed at a simulated altitude of 4,000 m. Twelve male healthy subjects spent 4 nights in a decompression chamber, 1 at sea level (baseline), 3 at 4,000 m to test zolpidem (10 mg), zaleplon (10 mg) and placebo, given...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000076723
更新日期:2004-01-01 00:00:00