Abstract:
:Premenstrual tension was studied in 16 females, using both biochemical and psychological parameters during the pre- and postmenstrual phases. Uptake of serotonin (5-HT) and the levels of 5-HT in platelet-rich plasma and platelet-poor plasmas were determined. Degrees of distress experienced pre- and postmenstrually were quantified via the Moos menstrual distress questionnaire. The mean Vmax was significantly lower during the premenstrual (tension) phase (8.2 +/- 0.9 pmol/min) as compared to the postmenstrual (normal) phase (14.4 +/- 3.2 pmol/min). There was no significant difference in the Km values. A highly significant (p less than 0.001) reduction in the levels of 5-HT in platelet-rich plasma (-23.2%) and platelet-poor plasma (-19.1%) was found during the premenstrual phase. There were correlations between the kinetic parameters of 5-HT uptake and some of the Moos symptoms.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Taylor DL,Mathew RJ,Ho BT,Weinman MLdoi
10.1159/000118103subject
Has Abstractpub_date
1984-01-01 00:00:00pages
16-8issue
1eissn
0302-282Xissn
1423-0224journal_volume
12pub_type
杂志文章abstract::Hallucinogenic drug-induced states are considered as models for acute schizophrenic disorders (experimental psychoses). In a double-blind study with healthy volunteers we investigated the influence of the serotonergic hallucinogen psilocybin, the ecstasy-like drug 3,4-methylenedioxyethylamphetamine (MDE), the stimulan...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000063672
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND/AIMS:Valproic acid or valproate (VA) is an anticonvulsant and mood-stabilizing drug primarily used in the treatment of epilepsy and bipolar disorder. Ziprasidone (ZPN) is an atypical antipsychotic drug used mainly for the treatment of schizophrenia. METHODS:This study is a part of our investigation on the c...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000327604
更新日期:2011-01-01 00:00:00
abstract::We have previously shown that the tilt aftereffect (TAE) appears to respond to changes in central dopaminergic function. In this study, the TAE was investigated during the preovulatory and the premenstrual phases of the menstrual cycle. Results in the preovulatory phase mimicked those previously found associated with ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119484
更新日期:1990-01-01 00:00:00
abstract::The search for specific predepressive personality factors has a long tradition in psychiatry. Studies in which assessments were made prospectively, before the onset of a first-ever episode of the illness, are, however, rare. In the present report from the Lundby Study we have investigated premorbid, mainly personality...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118956
更新日期:1993-01-01 00:00:00
abstract::Peripheral benzodiazepine receptors (PBR) have been identified in peripheral organs as well as in brain glial cells. PBR differ from central benzodiazepine receptors (CBR) in their lack of coupling to the gamma-aminobutyric acid receptors and the chloride ion channels. We investigated the effect of 21 days administrat...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026682
更新日期:2000-01-01 00:00:00
abstract::An auditory event-related potential paradigm was designed to objectively quantify the effects of drugs on the central nervous system (CNS). A series of tones was presented at three random interstimulus intervals (ISI). The amplitude of N1-P2 and the recovery of this complex across ISI appear to be rapid, reliable and ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118715
更新日期:1990-01-01 00:00:00
abstract::In the present study, the effects of short-acting benzodiazepines on nocturnal sleep and the carryover effects of these drugs were studied. The study involved 10 young, healthy male subjects who had given their written informed consent to participate. Either a placebo (PLA), 0.125 mg triazolam (TRZ), 0.25 mg TRZ or 0....
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000070586
更新日期:2003-01-01 00:00:00
abstract::Eight healthy paid male volunteers (age: 21-28 years, mean: 24.5 +/- 1.7 years; weight 62-79 kg) were administered via intravenous infusion (3 min) acute 25-, 50-, and 75-mg doses of phosphatidylserine, or matching placebo in a latin-square design. Multichannel EEG recordings were performed in baseline conditions, dur...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000119041
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:The present study investigated the effects of rapid tryptophan depletion (RTD), and the ensuing reduction of central nervous system levels of serotonin (5-HT), upon reactive aggression in patients with attention deficit/hyperactivity disorder (ADHD). Furthermore, it was asked whether the relation between 5-H...
journal_title:Neuropsychobiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000112951
更新日期:2007-01-01 00:00:00
abstract::Saliva cortisol was measured at 11 p.m. in a sample of 74 psychiatric inpatients composed of 24 primary endogenous depressives, 40 secondary depressives and 20 nondepressives (DSM III and Saint-Louis criteria). Primary depressives had significantly higher 11 p.m. saliva cortisol levels than nondepressives (p less than...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118384
更新日期:1987-01-01 00:00:00
abstract::The influence of restraint stress on potential aluminum (Al)-induced behavioral changes was assessed in CD-1 mice. Three groups of adult mice were given 0, 300 and 600 mg Al/kg body weight per day in drinking water for 2 weeks. One-half of the animals in each group were concurrently subjected to restraint stress durin...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026612
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVE:Previous results indicated a facilitated transcallosal inhibition via the corpus callosum (CC) in alexithymic male students. This study investigates transcallosal inhibition in alexithymic and nonalexithymic psychiatric inpatients. METHOD:Transcallosal inhibition was elicited by means of transcranial magneti...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000092218
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:The rs1344706 single nucleotide polymorphism in the ZNF804A gene is a common variant with strong evidence for association with schizophrenia. Recent studies show an association of rs1344706 with cognitive functioning, and there is some evidence suggesting that the risk allele may increase susceptibility for ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000339731
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:We have investigated the efficacy of high-frequency left (HFL) versus low-frequency right (LFR) repetitive transcranial magnetic stimulation (rTMS) in depression, focusing on specific symptoms as possible predictors of outcome for these two different types of stimulation. METHOD:Seventy-four outpatients wit...
journal_title:Neuropsychobiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000315439
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:The characterization of an individual's hypothalamic-pituitary-adrenal axis stress response is a main research topic in neuropsychobiology since alterations have been causally linked to several disease states. Over the last years, several studies focused on the identification of sources of inter- and intrain...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000115783
更新日期:2007-01-01 00:00:00
abstract::The new anticonvulsant, lamotrigine, is becoming an important tool in the treatment of bipolar disorder, including bipolar depression. Its efficacy in bipolar depression might be linked to its inhibition of serotonin uptake. We present the case of a female schizoaffective patient successfully treated with 400 mg of la...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026538
更新日期:1998-10-01 00:00:00
abstract::Ten closed head-injured patients and 10 matched control subjects participated in a study that examined quantitated EEG data during cognitive task performance. The head-injured patients performed significantly worse than controls on all four tasks and had significantly higher EEG amplitudes and amplitude variances. A d...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118471
更新日期:1988-01-01 00:00:00
abstract::Cephalosporins may induce nonconvulsive status epilepticus (NCSE), a potentially reversible condition. Despite the wide use of these antibiotics, there are only few reported cases, because this condition is probably underestimated. We report two new cases of NCSE occurring during treatment with cefepime and ceftazidim...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000077370
更新日期:2004-01-01 00:00:00
abstract::Fengabine is a new GABAmimetic compound active in animal models predictive of antidepressant activity. The present overview reports the results of 6 double-blind trials versus tricyclics (TCAs) (3 in outpatients and 3 in inpatients). Overall, 398 adult patients (149 males and 249 females) were treated; 194 with fengab...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000118485
更新日期:1989-01-01 00:00:00
abstract::An association between negative symptoms and frontal cortex abnormalities has been suggested in schizophrenic patients. We tested whether this association can be found when patients' task performance is good and while controlling for possible cortical atrophy. We investigated regional cerebral blood flow with the xeno...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119262
更新日期:1996-01-01 00:00:00
abstract::Morningness-eveningness preference by the self-rated Morningness-Eveningness Questionnaire (MEQ) has earlier been shown to be associated with the subjects' season of birth. Here, we obtain this result for a new sample of 2,125 university students and for the sample obtained by pooling the data with the earlier study, ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000067803
更新日期:2002-01-01 00:00:00
abstract::Two independent samples of psychiatric outpatients (n = 52 and 60) with blood type A or O completed the Brief Symptom Inventory, an abbreviated version of the SCL-90. In both samples patients with blood type A scored significantly higher than those with type O on the 'Obsessive-Compulsive' and 'Psychoticism' factors. ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118295
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Derangements of the gut microbiome have been linked to increased systemic inflammation and central nervous system disorders, including schizophrenia. This systematic review thus aimed to investigate the hypothesis that probiotic supplementation improves schizophrenia symptoms. METHODS:By using the keywords ...
journal_title:Neuropsychobiology
pub_type: 杂志文章,meta分析
doi:10.1159/000498862
更新日期:2019-01-01 00:00:00
abstract::Twenty-three chronic undifferentiated schizophrenics, 13 women and 10 men, aged 37-64 years with 15-to 40-year histories of the disease were given either thyrotropin-releasing hormone (TRH) (10 subjects) or DDAVP (13 subjects) with the aim to improve the negative symptoms of the disease and memory. TRH (600 micrograms...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118253
更新日期:1986-01-01 00:00:00
abstract::The prevalence of 3,4-methylenedioxymethamphetamine (MDMA) use has increased globally and the pattern of consumption has changed considerably. Previously, a subculture of MDMA users was fairly restricted to the dance club scene. More recently, use has spread outside of this subculture and now many users consume MDMA f...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000253549
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Structural brain changes and cognitive impairments have been identified as indicators of genetic risk for schizophrenia. However, the pattern of associations between such structural and functional liability markers has been less well investigated. METHODS:Magnetic resonance imaging data and cognitive assess...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000182889
更新日期:2008-01-01 00:00:00
abstract::Based on 5-HT hypothesis, L-5-HTP (150 or 300 mg/day) was given orally to 18 depressed patients. The global estimates were 2 very much improved; 8 much improved; 3 minimally improved, and 5 unchanged. The action of L-5-HTP was usually rapid. The elevation of the serum 5-HT level 1 week after L-5-HTP administration was...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117687
更新日期:1979-01-01 00:00:00
abstract:AIM:We describe the difficulties encountered in making a diagnosis where a somatic condition manifests itself alongside psychiatric symptoms associated with possible psychiatric comorbidities. METHODS:A case study is presented of a 15-year-old girl who was eventually diagnosed with ornithine transcarbamylase (OTC) def...
journal_title:Neuropsychobiology
pub_type:
doi:10.1159/000508679
更新日期:2020-07-20 00:00:00
abstract::Possible age effects on binding of [(3)H]lysergic acid diethylamide ([(3)H]LSD) to serotonin 5-HT(2A) receptors and of [(3)H]paroxetine to serotonin uptake sites were studied in platelets from healthy children (11-12 years of age), adolescents (16-17 years of age) and adults. Significant overall age effects were found...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026617
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVE:Patients with bulimia nervosa (BN) are reported to have decreased postprandial levels of cholecystokinin (CCK) and peptide YY (PYY). Fatty nutrients are the most powerful stimulus for releasing these peptides. Cholestyramine is an anion exchanger which adsorbs bile salts and reduces the digestion of lipids, a...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000368160
更新日期:2014-01-01 00:00:00