Psychiatric Symptoms as the First or Solitary Manifestation of Somatic Illnesses: Hyperammonaemia Type II.

Abstract:

AIM:We describe the difficulties encountered in making a diagnosis where a somatic condition manifests itself alongside psychiatric symptoms associated with possible psychiatric comorbidities. METHODS:A case study is presented of a 15-year-old girl who was eventually diagnosed with ornithine transcarbamylase (OTC) deficiency (hyperammonaemia type II), following an initial diagnosis of pervasive developmental disorder, selective mutism, and anorexia nervosa. RESULTS:The OTC disease is not fully expressed in females and its prevalence is lower than in males. Around 17-20% of female patients found with a defective OTC gene on an X chromosome can suffer from OTC deficiency that may result in elevated levels of ammonia in the blood; this occurs when one of the X chromosomes become inactivated. Patients typically present with nausea, migraines, and a history of dietary protein avoidance. In more severe cases, ataxia, confusion, hallucinations, and cerebral oedema can occur. The OTC deficiency can thus remain undiagnosed in women for many years. CONCLUSION:Somatic comorbidity in psychiatric inpatients is commonly found; however, such disorders are rarely diagnosed or even treated adequately.

journal_name

Neuropsychobiology

journal_title

Neuropsychobiology

authors

Niwinski P,Remberk B,Rybakowski F,Rokicki D

doi

10.1159/000508679

subject

Has Abstract

pub_date

2020-07-20 00:00:00

pages

1-5

eissn

0302-282X

issn

1423-0224

pii

000508679

pub_type

  • Interaction between Methylation and CpG Single-Nucleotide Polymorphisms in the HTR2A Gene: Association Analysis with Suicide Attempt in Schizophrenia.

    abstract::Dysfunctional mechanisms in the serotonergic system have been implicated in suicidal behavior among patients with schizophrenia. However, previous association analyses of major serotonin genes have provided inconsistent findings regarding their role in suicidal behavior. The goal of the current study was to identify s...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000441191

    authors: Bani-Fatemi A,Howe AS,Matmari M,Koga A,Zai C,Strauss J,De Luca V

    更新日期:2016-01-01 00:00:00

  • EEG source localization and global dimensional complexity in high- and low- hypnotizable subjects: a pilot study.

    abstract::Individuals differ in hypnotizability. Information on hypnotizability-related EEG characteristics is controversial and incomplete, particularly on intracerebral source localization and EEG dimensionality. 19-channel, eyes-closed resting EEGs from right-handed, healthy, 8 high- and 4 low-hynotizable subjects (age: 26.7...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000054942

    authors: Isotani T,Lehmann D,Pascual-Marqui RD,Kochi K,Wackermann J,Saito N,Yagyu T,Kinoshita T,Sasada K

    更新日期:2001-01-01 00:00:00

  • Extrapituitary effects of corticotropin-releasing hormone and thyrotropin-releasing hormone.

    abstract::Besides their regulation of the pituitary-adrenal and pituitary-thyroidal axis, respectively, the neurohormones CRH and TRH act within the central nervous system to evoke and modulate a number of behavioral and physiological processes. In particular, an increase in the sympathetic nervous system and respiratory activi...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章,评审

    doi:10.1159/000119000

    authors: Lehnert H,Nink M,Mann K,Röschke J,Hellhammer DH

    更新日期:1993-01-01 00:00:00

  • Soporific effect of the neurosteroid pregnanolone in relation to the substance's plasma level: a pilot study.

    abstract::The soporific effect of the neuroactive steroid pregnanolone, a metabolite of progesterone, and its relationship with plasma concentrations was assessed in 18 young, healthy, male volunteers for 2 h after administration of a single dose of pregnanolone prepared in two different formulations. Sedation was measured as s...

    journal_title:Neuropsychobiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000119300

    authors: Schulz H,Jobert M,Gee KW,Ashbrook DW

    更新日期:1996-01-01 00:00:00

  • Behaviour and social characteristics of young associal alcohol abusers.

    abstract::In the present study all available young social alcohol abusers in the capital of Iceland are compared with a control group matched for age and intellectual level. Certain behaviour and social characteristics were found to occur more often during childhood among the abusers. Boys showing these characteristics should b...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000117483

    authors: Helgason T,Asmundsson G

    更新日期:1975-01-01 00:00:00

  • Struggling and flumazenil effects in the swimming test are related to the level of anxiety in mice.

    abstract::The possible involvement of anxiety and learning/memory processes in escape-directed (struggling) behavior in a two-trial swimming test was investigated in mice, as well as the differential effects that low doses of flumazenil (a benzodiazepine receptor antagonist) could display depending on the animals' anxiety level...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000119058

    authors: Ferré P,Fernández Teruel A,Escorihuela RM,García E,Zapata A,Tobeña A

    更新日期:1994-01-01 00:00:00

  • Urinary brain-derived neurotrophic factor as a biomarker of executive functioning.

    abstract:BACKGROUND/AIMS:Neurotrophins such as brain-derived neurotrophic factor (BDNF) are vital for neuronal survival and adaptive plasticity. With high BDNF gene expression in the prefrontal cortex, BDNF is a potential regulatory factor for building and maintaining cognitive reserves. Recent studies suggest that individual d...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000362242

    authors: Koven NS,Collins LR

    更新日期:2014-01-01 00:00:00

  • Effects of single oral doses of bromazepam, buspirone and clobazam on performance tasks and memory.

    abstract::Three anxiolytic drugs (bromazepam 3 mg, buspirone 10 mg, and clobazam 10 mg p.o.) were evaluated for their effects on memory, psychomotor performance and subjective response in a double-blind, placebo-controlled, crossover study in 20 healthy volunteers. At each session, measurements were made before and 2 and 6 h af...

    journal_title:Neuropsychobiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000118609

    authors: Bourin M,Auget JL,Colombel MC,Larousse C

    更新日期:1989-01-01 00:00:00

  • Autumn peak in shooting suicides of children and adolescents from northern Finland.

    abstract::Suicide is one of the leading causes of death among adolescents worldwide. Studies on the seasonal pattern of youth suicides are rare and the results are very contradictory and heterogeneous. Generally, suicide methods affect the pattern of suicide seasonality. Shooting is the most common suicide method among Finnish ...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000098265

    authors: Lahti A,Räsänen P,Karvonen K,Särkioja T,Meyer-Rochow VB,Hakko H

    更新日期:2006-01-01 00:00:00

  • Naloxone reduces alcohol intake in a free-choice procedure even when both drinking bottles contain saccharin sodium or quinine substances.

    abstract::Male Wistar rats were able to drink water and different percentages of ethyl alcohol in a free-choice paradigm. Our results showed a clear-cut preference for 2 and 3% ethanol concentration. Addition of quinine in both drinking bottles increased preference for alcohol, while dilution of saccharin in both bottles totall...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118113

    authors: De Witte P

    更新日期:1984-01-01 00:00:00

  • Female Gender, Marital and Family Problems, and Feelings of Guilt Are Related to Self-Immolation Suicide Attempts.

    abstract:BACKGROUND:Self-immolation (SI) is considered one of the most painful, dramatic, and at the same time most inexplicable methods of suicide, with a high social impact. Prevalence rates are particularly high in Iran, and in north-western Iran specifically. Here, we report sociodemographic, psychological, and psychiatric ...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000487859

    authors: Ahmadpanah M,Rahighi AH,Haghighi M

    更新日期:2017-01-01 00:00:00

  • Effects of electroconvulsive therapy on frontal white matter in late-life depression: a diffusion tensor imaging study.

    abstract::This study was conducted to elucidate the effects of electroconvulsive therapy (ECT) on frontal white matter in late-life depressed patients. Diffusion tensor imaging was performed on 8 late-life depressed patients and 12 healthy age-matched controls. The patients were scanned before and after a course of ECT. Fractio...

    journal_title:Neuropsychobiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000077941

    authors: Nobuhara K,Okugawa G,Minami T,Takase K,Yoshida T,Yagyu T,Tajika A,Sugimoto T,Tamagaki C,Ikeda K,Sawada S,Kinoshita T

    更新日期:2004-01-01 00:00:00

  • Female genital disorder as adverse symptom of lamotrigine treatment. A serotoninergic effect?

    abstract::The new anticonvulsant, lamotrigine, is becoming an important tool in the treatment of bipolar disorder, including bipolar depression. Its efficacy in bipolar depression might be linked to its inhibition of serotonin uptake. We present the case of a female schizoaffective patient successfully treated with 400 mg of la...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000026538

    authors: Erfurth A,Amann B,Grunze H

    更新日期:1998-10-01 00:00:00

  • FKBP5 Gene Variants May Modulate Depressive Features in Bipolar Disorder.

    abstract:BACKGROUND:Previous evidence suggested the possible association of FK506 binding protein 5 (FKBP5) gene variants in bipolar disorder (BPD). OBJECTIVE:Given the need of refinement of the findings obtained in large but poorly phenotyped samples, this study investigated the possible role of variants within FKBP5 in a sma...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000499976

    authors: Calabrò M,Crisafulli C,Di Nicola M,Colombo R,Janiri L,Serretti A

    更新日期:2019-01-01 00:00:00

  • Anterior cingulate abnormality as a neural correlate of mismatch negativity in schizophrenia.

    abstract:BACKGROUND:Limbic circuitry, especially the anterior cingulate gyrus, has been implicated in the pathophysiology and cognitive changes of schizophrenia. Previous diffusion tensor imaging studies have demonstrated that the integrity of the anterior cingulum (AC) is abnormal in schizophrenia. However, the relationship be...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000355296

    authors: Hayakawa YK,Kirino E,Shimoji K,Kamagata K,Hori M,Ito K,Kunimatsu A,Abe O,Ohtomo K,Aoki S

    更新日期:2013-01-01 00:00:00

  • EEG and cognitive performance following closed head injury.

    abstract::Ten closed head-injured patients and 10 matched control subjects participated in a study that examined quantitated EEG data during cognitive task performance. The head-injured patients performed significantly worse than controls on all four tasks and had significantly higher EEG amplitudes and amplitude variances. A d...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118471

    authors: Randolph C,Miller MH

    更新日期:1988-01-01 00:00:00

  • Early visual processing over the menstrual cycle: the tilt aftereffect.

    abstract::We have previously shown that the tilt aftereffect (TAE) appears to respond to changes in central dopaminergic function. In this study, the TAE was investigated during the preovulatory and the premenstrual phases of the menstrual cycle. Results in the preovulatory phase mimicked those previously found associated with ...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000119484

    authors: Symons E,Calvert JE,Snelgar RS,Harris JP

    更新日期:1990-01-01 00:00:00

  • Plasma cortisol, catecholamine and cyclic AMP levels, response to dexamethasone suppression test and platelet MAO activity in manic-depressive patients. A longitudinal study.

    abstract::Plasma cortisol, catecholamine and cyclic AMP levels, response to dexamethasone suppression test and platelet MAO activity have been determined in 15 patients suffering from bipolar affective psychosis, each examined during a depressive, a manic and an euthymic phase, and in 15 sex- and age-matched normal controls. Me...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118071

    authors: Maj M,Ariano MG,Arena F,Kemali D

    更新日期:1984-01-01 00:00:00

  • (+/-)3,4-Methylenedioxymethamphetamine ('Ecstasy')-induced serotonin neurotoxicity: studies in animals.

    abstract::The popular recreational drug, (+/-)3, 4-methylenedioxymethamphetamine (MDMA; 'Ecstasy') is a potent and selective brain serotonin (5-HT) neurotoxin in animals. MDMA-induced 5-HT neurotoxicity can be demonstrated using a variety of neurochemical, neuroanatomical and, more recently, functional measures of 5-HT neurons....

    journal_title:Neuropsychobiology

    pub_type: 杂志文章,评审

    doi:10.1159/000026664

    authors: Ricaurte GA,Yuan J,McCann UD

    更新日期:2000-01-01 00:00:00

  • Risk factors for cardiovascular illness in panic disorder patients.

    abstract::Supine and standing heart rate (HR) and blood pressure measures were compared among 19 nonsmoking normal controls, 29 smoking patients and 36 nonsmoking patients with panic disorder. The smoking patients had a significantly higher supine HR, standing diastolic blood pressure, standing mean blood pressure and supine an...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000119440

    authors: Yeragani VK,Pohl R,Balon R,Ramesh C,Glitz D,Sherwood P

    更新日期:1990-01-01 00:00:00

  • Further results on the association between morningness-eveningness preference and the season of birth in human adults.

    abstract::Morningness-eveningness preference by the self-rated Morningness-Eveningness Questionnaire (MEQ) has earlier been shown to be associated with the subjects' season of birth. Here, we obtain this result for a new sample of 2,125 university students and for the sample obtained by pooling the data with the earlier study, ...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000067803

    authors: Natale V,Adan A,Chotai J

    更新日期:2002-01-01 00:00:00

  • Biochemical and diagnostic classification and serum drug levels: relation to antidepressive effect of imipramine.

    abstract::The relationship between clinical effect of imipramine (IP) in 39 depressed patients and biochemical distinction, serum drug levels, and diagnostic classification was investigated retrospectively. Based on pretreatment plasma ratios of tryptophan and tyrosine to competing amino acids, which reflect the availability of...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118182

    authors: Møller SE,Reisby N,Elley J,Krautwald O,Ortmann J,Larsen OB

    更新日期:1985-01-01 00:00:00

  • Symptom Profile and Clinical Course of Inpatients with Unipolar versus Bipolar Depression.

    abstract:BACKGROUND:Although differences in symptom profiles and outcome between depressive patients with an underlying major depressive disorder (MDD) and bipolar depression (BD) have been reported, studies with sequential short-interval assessments in a real-life inpatient setting are scarce. OBJECTIVES:To examine potential ...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000503686

    authors: Hebbrecht K,Stuivenga M,Birkenhäger T,van der Mast RC,Sabbe B,Giltay EJ

    更新日期:2020-01-01 00:00:00

  • State-of-the-Art Analysis of High-Frequency (Gamma Range) Electroencephalography in Humans.

    abstract::Gamma oscillations (>30 Hz) in the brain are involved in attention, perception and memory. They are altered in various pathological states, as well as by neuropharmaceuticals, so that they are of interest in drug and clinical investigations. However, when the human electroencephalogram is recorded on the scalp, this n...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000382023

    authors: Nottage JF,Horder J

    更新日期:2015-01-01 00:00:00

  • Probable cerebellar abnormality on N-isopropyl-(iodine-123)-p-iodoamphetamine single photon emission computed tomography scans in an epileptic patient receiving long-term high-dose phenytoin therapy.

    abstract::Quantitative assessment of regional cerebral blood flow (rCBF) was performed in a 22-year-old man with intractable temporal lobe epilepsy on long-term high-dose phenytoin (PHT) therapy, using single photon emission computed tomography (SPECT) with N-isopropyl-(iodine-123)-p-iodoamphetamine. In all the SPECT scans repe...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118982

    authors: Jibiki I,Kido H,Yamaguchi N,Matsuda H,Hisada K

    更新日期:1993-01-01 00:00:00

  • Serum Levels of Insulin-Like Growth Factor-1 and Obsessive-Compulsive Disorder: A Case-Control Study.

    abstract:BACKGROUND/AIMS:Recent findings suggest an involvement of insulin-like growth factor-1 (IGF-1) in the pathogenesis of many psychiatric disorders; however, there is a lack of data regarding IGF-1 in patients with obsessive-compulsive disorder (OCD). The aims of the present study were (1) to analyze putative alterations ...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000446918

    authors: Rosso G,Zanardini R,Chiodelli DF,Ferrari C,Gennarelli M,Bocchio-Chiavetto L

    更新日期:2016-01-01 00:00:00

  • Headache, panic disorder and depression: comorbidity or a spectrum?

    abstract::Past epidemiological and clinical research has identified depression as the most common psychiatric disorder associated with headache. The present study carried out in a neurology headache clinic showed that the major associations were with current anxiety disorders, especially panic and related conditions. These find...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000119182

    authors: Marazziti D,Toni C,Pedri S,Bonuccelli U,Pavese N,Nuti A,Muratorio A,Cassano GB,Akiskal HS

    更新日期:1995-01-01 00:00:00

  • Dysbindin and d-amino-acid-oxidase gene polymorphisms associated with positive and negative symptoms in schizophrenia.

    abstract:BACKGROUND:Schizophrenia is a genetically complex disorder with an unknown pathophysiology. Several genes implicated in glutamate metabolism have been associated with the disorder. Recent studies of polymorphisms in the dystrobrevin-binding protein 1 gene (DTNBP1; dysbindin) and D-amino-acid-oxidase (DAO) gene, both in...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000235799

    authors: Wirgenes KV,Djurovic S,Agartz I,Jonsson EG,Werge T,Melle I,Andreassen OA

    更新日期:2009-01-01 00:00:00

  • Caffeine use: is there a net benefit for mood and psychomotor performance?

    abstract::We agree with the conclusions of a recent article in this journal [James, Neuropsychobiology 1994;30:124-125] that studies on the psychoactive effects of caffeine need to take into account the possibility that the results obtained might represent merely the reversal of deleterious effects of caffeine deprivation rathe...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章,评审

    doi:10.1159/000119192

    authors: Rogers PJ,Richardson NJ,Dernoncourt C

    更新日期:1995-01-01 00:00:00

  • Psychophysiological aspects of phobic fears: an evaluative review.

    abstract::The present paper is a review of the use of psychophysiology in diagnosis and treatment of simple phobias. The paper begins with a definition and characterization of phobic fears, together with a description of prevalence rates, age onset, and gender differences. Acquisition is then discussed within a Three-Systems mo...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章,评审

    doi:10.1159/000118499

    authors: Hugdahl K

    更新日期:1988-01-01 00:00:00