Abstract:
:Three anxiolytic drugs (bromazepam 3 mg, buspirone 10 mg, and clobazam 10 mg p.o.) were evaluated for their effects on memory, psychomotor performance and subjective response in a double-blind, placebo-controlled, crossover study in 20 healthy volunteers. At each session, measurements were made before and 2 and 6 h after drug administration. The psychometric tests used were the images test, digit/symbol substitution test (DSST), choice reaction time (CRT), and critical fusion frequency (CFF). Free recall after 30 s in the 2-hour session was altered for all 3 drugs as compared to placebo (p less than 0.01), but in the 6-hour session only bromazepam showed a significant difference (p less than 0.05). The number of symbols reproduced by subjects during DSST was significantly decreased by bromazepam and buspirone as compared to placebo (p less than 0.05), whereas clobazam showed no differences with placebo. Analysis of variance for all four treatments (the 3 drugs and the placebo) showed no differences at recognition time or for motor response in CRT, except between bromazepam and clobazam after 6 h (p less than 0.05). None of the drugs altered performance during CFF (except bromazepam), and clobazam actually improved performance. All the drugs studied disturbed acquisition phenomena or restitution of memory; however, only bromazepam and buspirone significantly modified performance during DSST and disturbed the recognition and processing of sensory data.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Bourin M,Auget JL,Colombel MC,Larousse Cdoi
10.1159/000118609subject
Has Abstractpub_date
1989-01-01 00:00:00pages
141-5issue
3eissn
0302-282Xissn
1423-0224pii
118609journal_volume
22pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:Schizophrenia is a genetically complex disorder with an unknown pathophysiology. Several genes implicated in glutamate metabolism have been associated with the disorder. Recent studies of polymorphisms in the dystrobrevin-binding protein 1 gene (DTNBP1; dysbindin) and D-amino-acid-oxidase (DAO) gene, both in...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000235799
更新日期:2009-01-01 00:00:00
abstract:AIM:We describe the difficulties encountered in making a diagnosis where a somatic condition manifests itself alongside psychiatric symptoms associated with possible psychiatric comorbidities. METHODS:A case study is presented of a 15-year-old girl who was eventually diagnosed with ornithine transcarbamylase (OTC) def...
journal_title:Neuropsychobiology
pub_type:
doi:10.1159/000508679
更新日期:2020-07-20 00:00:00
abstract::Using event-related potentials (ERPs), a reduction in the auditory N100, N200 and P300 amplitude has been found in schizophrenic patients and may represent some pathophysiological deficit. Therefore, we investigated whether the genetic variant of the serotonin-2A receptor is associated with ERP change after clozapine ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000119017
更新日期:1993-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,meta分析,随机对照试验
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更新日期:1992-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Time of onset of antipsychotic action is still a debated matter. We aimed to replicate and extend previous findings that early response can predict subsequent non-response. METHODS:86 acutely psychotic patients treated with haloperidol were studied. RESULTS:A PANSS reduction ≤16% at 1 week predict...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000337739
更新日期:2012-01-01 00:00:00
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journal_title:Neuropsychobiology
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更新日期:2009-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
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更新日期:2003-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119171
更新日期:1995-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000066394
更新日期:2002-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119209
更新日期:1995-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
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更新日期:1990-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000119234
更新日期:1995-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119072
更新日期:1994-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117945
更新日期:1983-01-01 00:00:00
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journal_title:Neuropsychobiology
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更新日期:2003-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000054925
更新日期:2001-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117687
更新日期:1979-01-01 00:00:00
abstract::Twenty-three chronic undifferentiated schizophrenics, 13 women and 10 men, aged 37-64 years with 15-to 40-year histories of the disease were given either thyrotropin-releasing hormone (TRH) (10 subjects) or DDAVP (13 subjects) with the aim to improve the negative symptoms of the disease and memory. TRH (600 micrograms...
journal_title:Neuropsychobiology
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1987-01-01 00:00:00
abstract::In this study, we examined the effect of the 5-HT2A,C receptor agonist (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on locomotor activity and the head twitch response in rats by the repeated (twice daily for 4 days) subcutaneous administration of 0.9% saline (1 ml/kg) or (+/-)-3,4-Methylenedioxymethamphet...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026474
更新日期:1998-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119440
更新日期:1990-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117963
更新日期:1983-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000495522
更新日期:2019-01-01 00:00:00