Cytogenetic effects of valproic acid and ziprasidone in human lymphocyte cultures.

Abstract:

BACKGROUND/AIMS:Valproic acid or valproate (VA) is an anticonvulsant and mood-stabilizing drug primarily used in the treatment of epilepsy and bipolar disorder. Ziprasidone (ZPN) is an atypical antipsychotic drug used mainly for the treatment of schizophrenia. METHODS:This study is a part of our investigation on the cytogenetic effects of psychotropic drugs. Lymphocytes of peripheral blood cultures from 3 healthy donors treated with VA, ZPN and combinations of these (at concentrations equivalent to the oral doses) were used for the estimation of sister chromatid exchanges (SCEs) and the proliferation rate index (PRI). As a biomarker of genotoxicity, we used SCEs, one of the most sensitive methods reflecting DNA damage and/or subsequent DNA repair, and as a marker of cytostaticity we estimated the PRI. RESULTS:All treated lymphocyte cultures showed a statistically significant increase in SCE frequency and a significant decrease in PRI values (p<0.001). The combined effect of the drugs induced similar or more intense results, without reaching levels indicating synergistic action. CONCLUSION:This in vitro study investigated the cytogenetic activity of monotherapy vs. combined chronic drug exposure, and could form a catalyst for further investigations aiming to develop more efficacious therapy with decreased cytogenetic damage.

journal_name

Neuropsychobiology

journal_title

Neuropsychobiology

authors

Karapidaki I,Ekonomopoulou MT,Akritopoulou K,Anestakis D,Iakovidou-Kritsi Z

doi

10.1159/000327604

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

219-23

issue

4

eissn

0302-282X

issn

1423-0224

pii

000327604

journal_volume

64

pub_type

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