Abnormalities in behavior, learning ability, and the cholinergic system induced by long-term ultraviolet A irradiation of mice.

Abstract:

:Behavioral abnormalities, jumping reaction, increase in spontaneous activity abnormal violence, and lethargy were observed in long-term ultraviolet A (UVA)-irradiated hairy male Crj:CD-1 mice. The learning ability of 6- and 12-months UVA-irradiated mice was significantly reduced compared to un-irradiated age-matched mice. Acetylcholine levels, acetylcholinesterase and choline acetyltransferase activities in the whole brains were decreased in both of 6- and 12-month irradiated mice. Only 1 of 6 mice irradiated for 12 months was histologically observed to have a drastic loss of bilateral hippocampal pyramidal cells in the CA1 field of Ammon's horn.

journal_name

Neuropsychobiology

journal_title

Neuropsychobiology

authors

Hiramoto K,Okada T,Ito M

doi

10.1159/000119274

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

182-5

issue

4

eissn

0302-282X

issn

1423-0224

journal_volume

33

pub_type

杂志文章
  • Anterior pituitary responsiveness to hypothalamic hormones in anorexia nervosa.

    abstract::7 women and 3 men with anorexia nervosa were tested with thyrotropin-releasing hormone (TRH) and luteinizing hormone-follicle stimulating hormone-releasing hormone (LH-RH) and the growth hormone (GH), prolactin (PRL), gonadotropin (FSH-LH) and thyrotropin (TSH) responsiveness of their anterior pituitaries (AP) to the ...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000117854

    authors: Brambilla F,Cocchi D,Nobile P,Müller EE

    更新日期:1981-01-01 00:00:00

  • Relationship between alcoholism and CYP2E1 C/D polymorphism.

    abstract::The genotypes of the CYP2E1 loci of 35 alcoholic and 130 nonalcoholic (healthy controls) Japanese were investigated to determine the relationship between CYP2E1 (C/D) polymorphism and susceptibility to alcohol dependence. There was a significant (d.f. = 1, chi2 = 11.0, p < 0.001) difference in the CYP2E1 C gene freque...

    journal_title:Neuropsychobiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000026544

    authors: Iwahashi K,Ameno S,Ameno K,Okada N,Kinoshita H,Sakae Y,Nakamura K,Watanabe M,Ijiri I,Harada S

    更新日期:1998-11-01 00:00:00

  • Polymorphism of the serotonin transporter gene and symptomatic dimensions of schizophrenia in the Korean population.

    abstract::This study was aimed to test the association between schizophrenia and a functional serotonin polymorphism (5-HTTLPR) in the upstream regulatory region. Genomic DNA analysis with polymerase chain reaction was used for 5-HTTLPR genotyping. One hundred and eleven patients with schizophrenia and 208 healthy individuals p...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000071212

    authors: Pae CU,Kim JJ,Lee SJ,Lee CU,Lee C,Paik IH,Park HR,Yang S,Serretti A

    更新日期:2003-01-01 00:00:00

  • Different effects of cholestyramine on postprandial secretions of cholecystokinin and peptide YY in women with bulimia nervosa.

    abstract:OBJECTIVE:Patients with bulimia nervosa (BN) are reported to have decreased postprandial levels of cholecystokinin (CCK) and peptide YY (PYY). Fatty nutrients are the most powerful stimulus for releasing these peptides. Cholestyramine is an anion exchanger which adsorbs bile salts and reduces the digestion of lipids, a...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000368160

    authors: Rigamonti AE,Sartorio A,Scognamiglio P,Bini S,Monteleone AM,Mastromo D,Marazzi N,Cella SG,Monteleone P

    更新日期:2014-01-01 00:00:00

  • Working memory performance is associated with common glucocorticoid receptor gene polymorphisms.

    abstract::Cortisol has a modulatory influence on cognitive functions in humans. Both impairing and enhancing effects of cortisol administration have been shown for hippocampus-dependent declarative memory, and impairing effects have been shown for prefrontal-cortex-dependent working memory function. Given the high density of gl...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000262180

    authors: Kumsta R,Entringer S,Koper JW,van Rossum EF,Hellhammer DH,Wüst S

    更新日期:2010-01-01 00:00:00

  • Plasma 3,4-dihydroxyphenylethyleneglycol and therapeutic response to maprotiline and indalpine in major depression.

    abstract::Plasma levels of free and conjugated 3,4-dihydroxyphenylethyleneglycol (DOPEG), the main deaminated metabolite of norepinephrine, were assayed in 48 depressed patients before initiating a treatment with either maprotiline, an inhibitor of norepinephrine reuptake, or indalpine, a specific inhibitor of serotonin reuptak...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118243

    authors: Lôo H,Benkelfat C,Poirier MF,Vanelle JM,Olié JP,Dennis T,Scatton B

    更新日期:1986-01-01 00:00:00

  • The control of blepharospasm by essential fatty acids.

    abstract::Dopamine depletion induced by administration of Ro4-1284 produces a condition of rapid and repeated eye blinking in rats. This condition mimics the human disorder, blepharospasm, which often accompanies parkinsonism and other dopamine deficiency disorders. When given a 3-week course of a compound (SR-3) developed from...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000026648

    authors: Mostofsky DI,Yehuda S,Rabinovitz S,Carasso R

    更新日期:2000-01-01 00:00:00

  • Psychiatric Symptoms as the First or Solitary Manifestation of Somatic Illnesses: Hyperammonaemia Type II.

    abstract:AIM:We describe the difficulties encountered in making a diagnosis where a somatic condition manifests itself alongside psychiatric symptoms associated with possible psychiatric comorbidities. METHODS:A case study is presented of a 15-year-old girl who was eventually diagnosed with ornithine transcarbamylase (OTC) def...

    journal_title:Neuropsychobiology

    pub_type:

    doi:10.1159/000508679

    authors: Niwinski P,Remberk B,Rybakowski F,Rokicki D

    更新日期:2020-07-20 00:00:00

  • Female genital disorder as adverse symptom of lamotrigine treatment. A serotoninergic effect?

    abstract::The new anticonvulsant, lamotrigine, is becoming an important tool in the treatment of bipolar disorder, including bipolar depression. Its efficacy in bipolar depression might be linked to its inhibition of serotonin uptake. We present the case of a female schizoaffective patient successfully treated with 400 mg of la...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000026538

    authors: Erfurth A,Amann B,Grunze H

    更新日期:1998-10-01 00:00:00

  • Differential effects of ziprasidone and haloperidol on immobilization-stress-induced CRF mRNA expression in the hypothalamic paraventricular nucleus of rats.

    abstract:OBJECTIVES:Corticotropin-releasing factor (CRF) plays a prominent role in mediating the effect of stressors on the hypothalamic-pituitary-adrenal axis. In this study, we examined the effects of chronic administration of second-generation antipsychotic drug ziprasidone on CRF mRNA expression in the hypothalamic paravent...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000322288

    authors: Park SW,Choi SM,Lee JG,Lee CH,Lee SJ,Kim NR,Kim YH

    更新日期:2011-01-01 00:00:00

  • Gender-Related Brain Activations during an Emotional Task: An fMRI Study.

    abstract:BACKGROUND:Women have twice the rate of depression and anxiety disorders as men. Some studies suggest that this could be caused by women's greater sensitivity to negative emotions. Few brain imaging studies have compared the brain activity of men to women during a presentation of emotional stimuli. Our objective was to...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000499977

    authors: Thomas M,Gaudeau-Bosma C,Bouaziz N,Schenin-King Andrianisaina P,Benadhira R,Januel D,Moulier V

    更新日期:2019-01-01 00:00:00

  • Kindling with the beta-carboline FG7142 suggests separation between changes in seizure threshold and anxiety-related behaviour.

    abstract::The aim of this paper was to determine whether the prolonged decrease in seizure threshold produced by chemical kindling was accompanied by behavioural changes in tests of anxiety and aggression. The responses of rats in five tests were examined after chronic treatment with the benzodiazepine inverse agonist FG7142. T...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118460

    authors: Taylor SC,Johnston AL,Wilks LJ,Nicholass JM,File SE,Little HJ

    更新日期:1988-01-01 00:00:00

  • Parameters of alteration of pentobarbital response by hypothalamic polypeptides.

    abstract::Both thyrotropin-releasing hormone (TRH) and amphetamine antagonize pentobarbital. They are more effective in the day than at night. This is true for TRH even when the dose of pentobarbital is increased at night to prolong sedation. Under this condition the day-night difference is lost for amphetamine. Both substances...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000117484

    authors: Prange AJ Jr,Breese GR,Jahnke GD,Cooper BR,Cott JM,Wilson IC,Lipton MA,Plotnikoff NP

    更新日期:1975-01-01 00:00:00

  • Further results on the association between morningness-eveningness preference and the season of birth in human adults.

    abstract::Morningness-eveningness preference by the self-rated Morningness-Eveningness Questionnaire (MEQ) has earlier been shown to be associated with the subjects' season of birth. Here, we obtain this result for a new sample of 2,125 university students and for the sample obtained by pooling the data with the earlier study, ...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000067803

    authors: Natale V,Adan A,Chotai J

    更新日期:2002-01-01 00:00:00

  • Application of cluster analysis in the classification of depression. A replication study.

    abstract::This paper reports a replication study of a four-group cluster-analytic typology of depressed patients. Several hierarchial agglomerative clustering procedures were applied on the original patient sample using a slightly reduced variable pool. The best replication obtained used Ward's error sum of squares method and w...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000117595

    authors: Paykel ES,Henderson AJ

    更新日期:1977-01-01 00:00:00

  • Automated Source Estimation of Scalp EEG Epileptic Activity Using eLORETA Kurtosis Analysis.

    abstract:OBJECTIVES:eLORETA (exact low-resolution brain electromagnetic tomography) is a technique created by Pascual-Marqui et al. [Int J Psychophysiol. 1994 Oct; 18(1): 49-65] for the 3-dimensional representation of current source density in the brain by electroencephalography (EEG) data. Kurtosis analysis allows for the iden...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000495522

    authors: Ikeda S,Ishii R,Pascual-Marqui RD,Canuet L,Yoshimura M,Nishida K,Kitaura Y,Katsura K,Kinoshita T

    更新日期:2019-01-01 00:00:00

  • Long-term lithium treatment causes serotonin receptor down-regulation via serotonergic presynapses in rat brain.

    abstract::The effects of lithium treatment on serotonin (5-HT) receptors in rat frontal cortex and hippocampus were investigated. Long-term lithium treatment strongly blocked 5-hydroxytryptophan-induced head twitches, while acute lithium administration by itself induced head twitches in rats, and ketanserin blocked this acute l...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118292

    authors: Hotta I,Yamawaki S,Segawa T

    更新日期:1986-01-01 00:00:00

  • Analysis of physiological mechanism in psychopharmacology.

    abstract::Analysis of the mechanisms underlying the clinical effects of different drugs is a vital part of psychopharmacology. It is fair to say, however, that such analyses have thus far met with little success. This lack of success can be traced to a variety of sources that have flawed the analytical process itself. Detailed ...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118131

    authors: Carlton PL

    更新日期:1984-01-01 00:00:00

  • Long-term effects of alprazolam and imipramine on cerebrospinal fluid monoamine metabolites and neuropeptides in panic disorder.

    abstract::Cerebrospinal fluid (CSF) homovanillic acid, 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenylglycol, and somatostatin and beta-endorphin levels were measured in 12 patients with panic disorder before and after 7 months of treatment with alprazolam or imipramine. The concentrations of CSF monoamine metabolites and...

    journal_title:Neuropsychobiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000118574

    authors: Lepola U,Jolkkonen J,Rimón R,Riekkinen P

    更新日期:1989-01-01 00:00:00

  • Schizotypal traits in healthy women predict prefrontal activation patterns during a verbal fluency task: a near-infrared spectroscopy study.

    abstract:BACKGROUND/AIMS:Previous functional neuroimaging studies have reported that patients with schizophrenia show reduced prefrontal activation during cognitive tasks whereas patients with schizotypal personality disorder (SPD) show preserved or even increased right prefrontal activation, compared to healthy controls; on th...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000129669

    authors: Hori H,Nagamine M,Soshi T,Okabe S,Kim Y,Kunugi H

    更新日期:2008-01-01 00:00:00

  • Physiological Differences in the Follicular, Luteal, and Menstrual Phases in Healthy Women Determined by Electrovestibulography: Depression, Anxiety, or Other Associations?

    abstract::Electrovestibulography (EVestG) recordings have been previously applied toward classifying and/or measuring the severity of several neurological disorders including depression with and without anxiety. This study's objectives were to: (1) extract EVestG features representing physiological differences of healthy women ...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000487771

    authors: Lithgow BJ,Moussavi Z

    更新日期:2017-01-01 00:00:00

  • Dysbindin and d-amino-acid-oxidase gene polymorphisms associated with positive and negative symptoms in schizophrenia.

    abstract:BACKGROUND:Schizophrenia is a genetically complex disorder with an unknown pathophysiology. Several genes implicated in glutamate metabolism have been associated with the disorder. Recent studies of polymorphisms in the dystrobrevin-binding protein 1 gene (DTNBP1; dysbindin) and D-amino-acid-oxidase (DAO) gene, both in...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000235799

    authors: Wirgenes KV,Djurovic S,Agartz I,Jonsson EG,Werge T,Melle I,Andreassen OA

    更新日期:2009-01-01 00:00:00

  • Effects of single oral doses of bromazepam, buspirone and clobazam on performance tasks and memory.

    abstract::Three anxiolytic drugs (bromazepam 3 mg, buspirone 10 mg, and clobazam 10 mg p.o.) were evaluated for their effects on memory, psychomotor performance and subjective response in a double-blind, placebo-controlled, crossover study in 20 healthy volunteers. At each session, measurements were made before and 2 and 6 h af...

    journal_title:Neuropsychobiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000118609

    authors: Bourin M,Auget JL,Colombel MC,Larousse C

    更新日期:1989-01-01 00:00:00

  • No association between tryptophan hydroxylase gene polymorphism and Alzheimer's disease.

    abstract::Serotonergic dysfunction is implicated in Alzheimer's disease (AD) on the basis of studies of serotonin and its metabolite in postmortem specimens and CSF. There were also reports on association of a tryptophan hydroxylase (TPH) intron 7 variant and CSF 5-hydroxyindoleacetic acid concentrations. These suggested TPH mi...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000054856

    authors: Wang YC,Tsai SJ,Liu TY,Liu HC,Hong CJ

    更新日期:2001-01-01 00:00:00

  • Insomnia and alpha sleep in chronic non-organic pain as compared to primary insomnia.

    abstract::A considerable proportion of chronic non-organic pain patients suffer from insomnia, and alpha sleep has been suggested to be specifically associated with fibromyalgia. However, the clinical significance of those symptoms is not clear. This study was carried out to investigate this question. Twenty-six middle-aged, no...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000054866

    authors: Schneider-Helmert D,Whitehouse I,Kumar A,Lijzenga C

    更新日期:2001-01-01 00:00:00

  • Early visual processing over the menstrual cycle: the tilt aftereffect.

    abstract::We have previously shown that the tilt aftereffect (TAE) appears to respond to changes in central dopaminergic function. In this study, the TAE was investigated during the preovulatory and the premenstrual phases of the menstrual cycle. Results in the preovulatory phase mimicked those previously found associated with ...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000119484

    authors: Symons E,Calvert JE,Snelgar RS,Harris JP

    更新日期:1990-01-01 00:00:00

  • Too difficult to stop: mechanisms facilitating relapse in alcohol dependence.

    abstract:BACKGROUND:In alcohol and other substance dependencies, patients often suffer relapse despite better knowledge and their intention to remain abstinent. A variety of neurotransmitter systems and their respective alterations due to the chronic drug intake are involved in mechanisms that facilitate relapse. It has been po...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章,评审

    doi:10.1159/000362838

    authors: Garbusow M,Sebold M,Beck A,Heinz A

    更新日期:2014-01-01 00:00:00

  • Evolution of blood magnesium, sodium and potassium in depressed patients followed for three months.

    abstract::No consensus has been obtained about blood electrolyte status, especially about magnesium, in affective disorders. This is mainly due to the lack of information about the distribution of the patients in clinical subgroups, sex, type of treatment and about the severity of their illnesses. Most of these studies concerne...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118914

    authors: Widmer J,Bovier P,Karege F,Raffin Y,Hilleret H,Gaillard JM,Tissot R

    更新日期:1992-01-01 00:00:00

  • Reactive depression: a follow-up.

    abstract::93 cases of reactive depression have been followed up in order to investigate the long-term course of illness. By independent classification of reactive and endogenous depressions the authors agreed on diagnosis for 94%. Ten subgroups of reactive depressions are illustrated by case histories. It is of practical import...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000117739

    authors: Refsum HE,Astrup C

    更新日期:1980-01-01 00:00:00

  • Relationship of N-acetyl-beta- glucosaminidase levels to seriousness of suicide attempts.

    abstract::We hypothesized that levels of N-acetyl-beta-glucosaminidase (NAG) would differ between patients making serious versus nonserious suicide attempts. The levels of NAG from 11 patients hospitalized for serious suicide attempts were compared to 5 patients whose suicide attempts were not rated serious. There was a signifi...

    journal_title:Neuropsychobiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000026688

    authors: Garvey MJ,Underwood K

    更新日期:2000-01-01 00:00:00