Abstract:
OBJECTIVES:Corticotropin-releasing factor (CRF) plays a prominent role in mediating the effect of stressors on the hypothalamic-pituitary-adrenal axis. In this study, we examined the effects of chronic administration of second-generation antipsychotic drug ziprasidone on CRF mRNA expression in the hypothalamic paraventricular nucleus (PVN) of rats with or without immobilization stress. METHODS:The rats were subjected to immobilization stress 2 h/day for 3 weeks. The effect of ziprasidone (2.5 mg/kg, 21 days) on CRF mRNA expression was determined using in situ hybridization of tissue sections from the rat hypothalamic PVN. Haloperidol (1.0 mg/kg, 21 days) was used for comparison. RESULTS:Haloperidol increased the expression of CRF mRNA in the PVN under basal conditions, whereas ziprasidone had no effect. Chronic immobilization stress increased CRF expression. The chronic administration of ziprasidone prevented the increase in CRF mRNA expression caused by immobilization stress. CONCLUSIONS:These results suggest that ziprasidone may have a regulatory effect on the stress-induced CRF mRNA expression and a role in the treatment of depressive mood symptom.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Park SW,Choi SM,Lee JG,Lee CH,Lee SJ,Kim NR,Kim YHdoi
10.1159/000322288subject
Has Abstractpub_date
2011-01-01 00:00:00pages
29-34issue
1eissn
0302-282Xissn
1423-0224pii
000322288journal_volume
63pub_type
杂志文章abstract:BACKGROUND:Previous evidence suggested the possible association of FK506 binding protein 5 (FKBP5) gene variants in bipolar disorder (BPD). OBJECTIVE:Given the need of refinement of the findings obtained in large but poorly phenotyped samples, this study investigated the possible role of variants within FKBP5 in a sma...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000499976
更新日期:2019-01-01 00:00:00
abstract::In two studies experimentally induced colds slowed the speed of response in a serial reaction task. Responding was also slower during the incubation period of the illness, which shows that performance on such a task may be used to predict subsequent illness. Volunteers who had no significant clinical illness, but who ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118408
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abstract:BACKGROUND:In depressed patients, overstimulation of the hypothalamo-pituitary-adrenocortical (HPA) system, probably caused by glucocorticoid receptor resistance, is the most consistent neurobiological finding. Glucocorticoids themselves are reported to increase leptin synthesis and secretion in humans. METHODS:We exa...
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pub_type: 临床试验,杂志文章
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更新日期:2007-01-01 00:00:00
abstract::A considerable proportion of chronic non-organic pain patients suffer from insomnia, and alpha sleep has been suggested to be specifically associated with fibromyalgia. However, the clinical significance of those symptoms is not clear. This study was carried out to investigate this question. Twenty-six middle-aged, no...
journal_title:Neuropsychobiology
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doi:10.1159/000054866
更新日期:2001-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
doi:10.1159/000503750
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journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000119336
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pub_type: 杂志文章,评审
doi:10.1159/000119304
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abstract::Gamma-aminobutyric acid-B (GABAB) binding sites labelled with [3H]GABA were determined in postmortem frontal cortex samples of 20 control subjects and 16 suicides. The suicide group was further subdivided according to the method of suicide and the existence of depressive symptoms prior to death. No significant differe...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118893
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journal_title:Neuropsychobiology
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journal_title:Neuropsychobiology
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journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000118340
更新日期:1987-01-01 00:00:00
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journal_title:Neuropsychobiology
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doi:10.1159/000118071
更新日期:1984-01-01 00:00:00
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journal_title:Neuropsychobiology
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doi:10.1159/000026639
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journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000118499
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journal_title:Neuropsychobiology
pub_type: 历史文章,杂志文章
doi:10.1159/000118407
更新日期:1987-01-01 00:00:00
abstract::Single, 50- and 100-mg oral doses of phenobarbital and a matching placebo were administered double-blind to 8 young, healthy male subjects. Multilead electroencephalographic (EEG) samples were recorded prior to, and at regular intervals within the 2 h following administration. The EEG signal was processed by power spe...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
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更新日期:1990-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000118618
更新日期:1989-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000223730
更新日期:2009-01-01 00:00:00
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journal_title:Neuropsychobiology
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118182
更新日期:1985-01-01 00:00:00
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journal_title:Neuropsychobiology
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doi:10.1159/000119262
更新日期:1996-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000075338
更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000182889
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:Abnormalities in different parameters of the norepinephrine system have been widely described in major depression. The presence of alpha(2)-adrenoreceptors in blood platelets, similar to those in the brain, prompted us to evaluate them in depressed patients, as compared with healthy controls. METHODS:Fiftee...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000054930
更新日期:2001-01-01 00:00:00
abstract::Dysfunctional mechanisms in the serotonergic system have been implicated in suicidal behavior among patients with schizophrenia. However, previous association analyses of major serotonin genes have provided inconsistent findings regarding their role in suicidal behavior. The goal of the current study was to identify s...
journal_title:Neuropsychobiology
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更新日期:2016-01-01 00:00:00
abstract::In contrast to the single-channel dimensional complexity, the global dimensional complexity is calculated from a multichannel EEG. The intention with the method is to measure the spatial distribution of information processing in the brain. The method seems to be of interest in psychopharmacological research, but the i...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119171
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Cytokines do not only mediate responses to infection, but are also involved in behavioral and physiological responses to psychological stressors. IL-6 has received special attention in relation to the development of posttraumatic stress disorders and depression. OBJECTIVE:We tested effects of prior injectio...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000099946
更新日期:2006-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
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更新日期:1992-01-01 00:00:00
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更新日期:2015-01-01 00:00:00