Serum levels of carnitine in chronic fatigue syndrome: clinical correlates.

Abstract:

:Carnitine is essential for mitochondrial energy production. Disturbance in mitochondrial function may contribute to or cause the fatigue seen in chronic fatigue syndrome (CFS) patients. One previous investigation has reported decreased acylcarnitine levels in 38 CFS patients. We investigated 35 CFS patients (27 females and 8 males); our results indicate that CFS patients have statistically significantly lower serum total carnitine, free carnitine and acylcarnitine levels, not only lower acylcarnitine levels as previously reported. We also found a statistically significant correlation between serum levels of total and free carnitine and clinical symptomatology. Higher serum carnitine levels correlated with better functional capacity. These findings may be indicative of mitochondrial dysfunction, which may contribute to or cause symptoms of fatigue in CFS patients.

journal_name

Neuropsychobiology

journal_title

Neuropsychobiology

authors

Plioplys AV,Plioplys S

doi

10.1159/000119226

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

132-8

issue

3

eissn

0302-282X

issn

1423-0224

journal_volume

32

pub_type

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