Abstract:
:Evidence from preclinical studies, preliminary clinical reports, pharmacologic challenge studies and a small number of controlled trials suggests that several antiepileptic agents--valproate, carbamazepine, and clonazepam--may have therapeutic effects in the treatment of patients with panic disorder. We review the theoretical basis and available clinical data supporting the use of these agents in panic disorder.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Keck PE Jr,McElroy SL,Tugrul KC,Bennett JA,Smith JMdoi
10.1159/000118971subject
Has Abstractpub_date
1993-01-01 00:00:00pages
150-3issue
3eissn
0302-282Xissn
1423-0224pii
118971journal_volume
27pub_type
杂志文章,评审abstract::In contrast to the single-channel dimensional complexity, the global dimensional complexity is calculated from a multichannel EEG. The intention with the method is to measure the spatial distribution of information processing in the brain. The method seems to be of interest in psychopharmacological research, but the i...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119171
更新日期:1995-01-01 00:00:00
abstract::This study investigated the acute effect of a dose range of low-to-moderate binge-like methamphetamine treatments on the regional expression of neurotrophin proteins in the brain and serum 2 h after the last dose, in addition to assessing the behavioural effects and dopamine neurotransmitter changes produced. Male Spr...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000480513
更新日期:2017-01-01 00:00:00
abstract::1,927 outpatients were included by 392 general practitioners in an open study in order to evaluate the safety of tianeptine in the ambulatory treatment of depression. The results of 1,858 depressed patients without melancholia and psychotic features, fulfilling DSM III criteria of Major Depressive Episode or Dysthymic...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118824
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:Schizophrenia, a common neurological disorder appearing in the late teens or early adulthood, is characterized by disorganized thinking, behaviour, and perception of emotions. Aberrant N-methyl-D-aspartate (NMDA) receptor-mediated synaptic plasticity is a major pathological event here due to dysfunction of do...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000454985
更新日期:2016-01-01 00:00:00
abstract::Spontaneous and drug-induced locomotor behavior was investigated in rats subjected to lesions of the ventral striatum, using the neurotoxin 6-hydroxydopamine to produce selective depletions of dopamine. Locomotor activity changed with time after lesion. At 2 weeks postoperative less spontaneous rearings were observed ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118311
更新日期:1986-01-01 00:00:00
abstract::A double-blind comparison of zimeldine, a selective 5-HT reuptake inhibitor, and nomifensine, a noradrenaline and a dopamine reuptake inhibitor, was carried out in 43 inpatients with a scheduled treatment period of 6 weeks. All patients were diagnosed as definite major depressive disorder according to Research Diagnos...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000118086
更新日期:1984-01-01 00:00:00
abstract::Somatosensory event-related potentials (SERP) were recorded in 30 chronic young schizophrenic patients and in 15 age-matched controls. Objective SERP parameters were latencies, amplitudes and the determination of areas of the cognitive components N1 and P3 by integration. Highly significantly reduced areas and prolong...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118568
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:Olfactory processing depends on dopamine metabolism and orbitofrontal cortex functioning, both known to be disturbed in attention-deficit/hyperactivity disorder (ADHD). Some investigations suggested alterations in olfactory processing (identification and sensitivity) in childhood and adult ADHD. METHODS:In t...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000323448
更新日期:2011-01-01 00:00:00
abstract::Eight patients with chronic obsessive-compulsive neurosis were subjected to trazodone, an antidepressant acting on the serotonergic system. After 4 weeks of treatment, 6 showed significant reduction in the obsessional symptoms which was sustained after a 6-week follow-up. The 2 patients who did not show improvement ha...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118274
更新日期:1986-01-01 00:00:00
abstract::Tardive dyskinesia caused by antipsychotic treatment is a severe problem not only in the management of schizophrenia, but also of affective disorders. Vitamin E monotherapy has been used in schizophrenic patients with tardive dyskinesia. Pharmacologists warn against high dosage of vitamin E because of its pro-oxidativ...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000068019
更新日期:2002-01-01 00:00:00
abstract::As low-dose amphetamine stimulation of locomotor activity in the rat depends upon a mesolimbic dopaminergic substrate, neuroleptic antagonism of this behavior has been suggested as a model for studying antipsychotic activity. Animals in the present study received 21 days of chronic treatment with 1.0 mg/kg amphetamine...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118442
更新日期:1988-01-01 00:00:00
abstract::The effects of zolpidem or zaleplon on sleep architecture, respiratory patterns and performance were assessed at a simulated altitude of 4,000 m. Twelve male healthy subjects spent 4 nights in a decompression chamber, 1 at sea level (baseline), 3 at 4,000 m to test zolpidem (10 mg), zaleplon (10 mg) and placebo, given...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000076723
更新日期:2004-01-01 00:00:00
abstract::Besides their regulation of the pituitary-adrenal and pituitary-thyroidal axis, respectively, the neurohormones CRH and TRH act within the central nervous system to evoke and modulate a number of behavioral and physiological processes. In particular, an increase in the sympathetic nervous system and respiratory activi...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000119000
更新日期:1993-01-01 00:00:00
abstract::The prevalence of 3,4-methylenedioxymethamphetamine (MDMA) use has increased globally and the pattern of consumption has changed considerably. Previously, a subculture of MDMA users was fairly restricted to the dance club scene. More recently, use has spread outside of this subculture and now many users consume MDMA f...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000253549
更新日期:2009-01-01 00:00:00
abstract::Morningness-eveningness preference by the self-rated Morningness-Eveningness Questionnaire (MEQ) has earlier been shown to be associated with the subjects' season of birth. Here, we obtain this result for a new sample of 2,125 university students and for the sample obtained by pooling the data with the earlier study, ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000067803
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:Memory processes, as reflected by 'old/new' effects of event-related potentials (ERPs), have been shown to be impaired in depressed patients. This variability might be partly explained by biological factors. S100B is a glial calcium-binding protein with neuroplastic properties; S100B serum levels have been sh...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000219304
更新日期:2009-01-01 00:00:00
abstract::Suicide is a major problem for psychiatry. Depression is the most common mental disorder related to suicidal behavior. The present study aimed at investigating the relationship between the symptomatology related to death, dying, and suicide and neurobiological factors in depressed patients. Fifty patients aged 21-60 y...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000075338
更新日期:2004-01-01 00:00:00
abstract::The growing number of studies examining the relationship between suicide and lipid metabolism are based upon studies suggesting that cholesterol-lowering procedures may increase the risk of death due to suicide or impulsive-aggressive behavior. Leptin seems to be strongly associated with lipid metabolism. In the prese...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000054950
更新日期:2002-01-01 00:00:00
abstract::Plasma levels of free and conjugated 3,4-dihydroxyphenylethyleneglycol (DOPEG), the main deaminated metabolite of norepinephrine, were assayed in 48 depressed patients before initiating a treatment with either maprotiline, an inhibitor of norepinephrine reuptake, or indalpine, a specific inhibitor of serotonin reuptak...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118243
更新日期:1986-01-01 00:00:00
abstract::Genetic polymorphism of the serotonin 5-HT(2A) receptor seems to be associated with therapeutic response to selective serotonin reuptake inhibitors (SSRIs). The present study investigated whether a novel -1438G/A polymorphism in the promoter region of the 5-HT(2A )receptor gene is associated with therapeutic response ...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000066394
更新日期:2002-01-01 00:00:00
abstract::Disturbances in the serotonergic neurotransmission system have been implicated in the etiology of attention deficit/hyperactivity disorder (ADHD). As the importance of genetic factors is well established, genes encoding for proteins of the serotonergic pathway are important candidates to unravel the underlying genetic...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000068870
更新日期:2003-01-01 00:00:00
abstract::An electric potential measurement tells us only about the difference between two electrode locations. When prior experiments or present measurements prove that an electrode's location is inactive (especially in 'mono-polar' or scalp-to-reference technique), then EEG records and EEG maps can be interpreted regionally n...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118093
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Structural brain changes and cognitive impairments have been identified as indicators of genetic risk for schizophrenia. However, the pattern of associations between such structural and functional liability markers has been less well investigated. METHODS:Magnetic resonance imaging data and cognitive assess...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000182889
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND AND AIM:Repetitive transcranial magnetic stimulation (rTMS) is supposed to be not as effective in severe depression as it is in medium depression. We evaluated the treatment response to an ultra-high-frequency (UHF; 30 Hz) approach, which was used to maximize the rTMS efficacy in severely ill patients. METH...
journal_title:Neuropsychobiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000339561
更新日期:2012-01-01 00:00:00
abstract::Urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) levels in 53 depressed women were compared to current suicidal thoughts or activity. Comparisons were also made between MHPG and past suicide attempts, number of past attempts, and seriousness of the worst attempt. There was a weak trend for current but not past suicidali...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119072
更新日期:1994-01-01 00:00:00
abstract::Prolactin (PRL) and growth hormone (GH) response to L-Dopa have been studied in 51 affectively ill women (26 unipolar and 25 bipolar) before and after amitriptyline treatment and in 14 normal female controls. There was no difference in GH response to L-dopa in all groups studied except for bipolar postmenopausal women...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117947
更新日期:1983-01-01 00:00:00
abstract::Plasma cortisol, catecholamine and cyclic AMP levels, response to dexamethasone suppression test and platelet MAO activity have been determined in 15 patients suffering from bipolar affective psychosis, each examined during a depressive, a manic and an euthymic phase, and in 15 sex- and age-matched normal controls. Me...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118071
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Panic disorder (PD) is a common and often chronic psychiatric condition that can lead to considerable disability in daily life. Using [(18)F]fluorodeoxyglucose-PET, we examined brain baseline glucose metabolism in PD patients in comparison with normal controls and the changes in glucose metabolism after 12 w...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000337740
更新日期:2012-01-01 00:00:00
abstract::Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine and these neurotransmitters are hypothesized to be involved in the cognitive function of humans. This study of a cohort of 191 healthy young Chinese females attempts to utilize the intelligence qu...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000086609
更新日期:2005-01-01 00:00:00
abstract::The relationship between clinical effect of imipramine (IP) in 39 depressed patients and biochemical distinction, serum drug levels, and diagnostic classification was investigated retrospectively. Based on pretreatment plasma ratios of tryptophan and tyrosine to competing amino acids, which reflect the availability of...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118182
更新日期:1985-01-01 00:00:00