Abstract:
:Prolactin (PRL) and growth hormone (GH) response to L-Dopa have been studied in 51 affectively ill women (26 unipolar and 25 bipolar) before and after amitriptyline treatment and in 14 normal female controls. There was no difference in GH response to L-dopa in all groups studied except for bipolar postmenopausal women, who showed a blunted GH response to L-Dopa compared to bipolar premenopausal women. After amitriptyline treatment, no difference in GH response was found in all groups studied. Basal PRL levels were significantly lower in unipolar premenopausal and bipolar premenopausal patients in comparison to their controls. PRL response to L-Dopa was significantly less inhibited in postmenopausal controls than in premenopausal controls and in bipolar premenopausal patients compared to premenopausal controls. These data provide further evidence of hypothalamo-pituitary dysfunction in subgroups of affective disorders and emphasize the importance of considering the menopausal status in neuroendocrine studies of psychiatric disorders.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Linkowski P,Brauman H,Mendlewicz Jdoi
10.1159/000117947subject
Has Abstractpub_date
1983-01-01 00:00:00pages
108-12issue
2-3eissn
0302-282Xissn
1423-0224journal_volume
9pub_type
杂志文章abstract::Administration of progesterone produces sleep EEG patterns that resemble those of agonistic modulators at the GABAA receptor. Previous studies evaluating the effects of an oral progesterone administration on attention performance in females pointed to putative sedative effects of progesterone at high dosages. However,...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000119336
更新日期:1997-01-01 00:00:00
abstract::Failure to gain weight during withdrawal from chronic regimens of dependence-producing drugs is observed in laboratory rats. Withdrawal from the benzodiazepine anxiolytic agent diazepam, whether induced by cessation of treatment or precipitated by administration of the specific benzodiazepine antagonist Ro-15,1788, is...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118291
更新日期:1986-01-01 00:00:00
abstract::Besides their regulation of the pituitary-adrenal and pituitary-thyroidal axis, respectively, the neurohormones CRH and TRH act within the central nervous system to evoke and modulate a number of behavioral and physiological processes. In particular, an increase in the sympathetic nervous system and respiratory activi...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000119000
更新日期:1993-01-01 00:00:00
abstract::Nitric oxide (NO) has been implicated to play a role in the pathogenesis of depressive disorders. Adrenomedullin (AM) induces vasorelaxation by activating adenylate cyclase and also by stimulating the release of NO. AM immune reactivity is present in the brain, consistent with a role as neurotransmitter. Therefore, it...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000048677
更新日期:2002-01-01 00:00:00
abstract::The responses of cortisol to acute administration of saline and of clonidine (2.5 micrograms/kg B.W.) were examined in 10 children and adolescents with major depressive disorder and in 10 age- and sex-matched controls. Clonidine administration did not inhibit cortisol secretion in controls or in patients, contrary to ...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000119022
更新日期:1993-01-01 00:00:00
abstract::Renal lithium clearance and the serum lithium levels following a single oral loading dose of lithium were used as measures to predict lithium dose requirement during long-term maintenance at 3 different psychiatric centers in North America. Saliva lithium values were also investigated at one of the centers. The correl...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117844
更新日期:1981-01-01 00:00:00
abstract::Quantitative pharmaco-EEG has become a useful technique for determining pharmacodynamic parameters after CNS-active drug administration. Nevertheless, one of the most important problems faced by practitioners of pharmaco-EEG is the difficulty in evaluating drug-specific effects. In this article, a methodology for comp...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119068
更新日期:1994-01-01 00:00:00
abstract::Little is known about the effects of cocaine on cognitive tasks. Event-related potentials (ERP) were recorded in 7 cocaine abusers during the performance of the auditory oddball task before and after the intravenous injections of saline and cocaine (60-80 mg). The P3B and slow wave components of the ERP were significa...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000119148
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Time of onset of antipsychotic action is still a debated matter. We aimed to replicate and extend previous findings that early response can predict subsequent non-response. METHODS:86 acutely psychotic patients treated with haloperidol were studied. RESULTS:A PANSS reduction ≤16% at 1 week predict...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000337739
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Panic disorder (PD) is a common and often chronic psychiatric condition that can lead to considerable disability in daily life. Using [(18)F]fluorodeoxyglucose-PET, we examined brain baseline glucose metabolism in PD patients in comparison with normal controls and the changes in glucose metabolism after 12 w...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000337740
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:We examined striatal dopamine transporter (DAT) binding in bipolar and unipolar depressed patients and compared these values to those obtained from healthy control subjects using the selective DAT radioligand [(99m)Tc]TRODAT-1 and single photon emission computed tomography imaging. We hypothesized that DAT le...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000106476
更新日期:2007-01-01 00:00:00
abstract::28 cases of suicide committed in a Swedish population subjected to repeated psychiatric investigations are described. Two groups of controls were selected from the same population: sex- and age-matched living persons (normal group) and sex-matched persons who had died from organic disease at ages corresponding to thos...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117666
更新日期:1979-01-01 00:00:00
abstract::In the present study all available young social alcohol abusers in the capital of Iceland are compared with a control group matched for age and intellectual level. Certain behaviour and social characteristics were found to occur more often during childhood among the abusers. Boys showing these characteristics should b...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117483
更新日期:1975-01-01 00:00:00
abstract::To evaluate the effect of the odor of incense on brain activity, electroencephalograms (EEGs) and event-related potentials (ERPs) in a push/wait paradigm were recorded in 10 healthy adults (aged 23-39 years) with normal olfactory function. EEG was recorded from 21 electrodes on the scalp, according to the Internationa...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000209859
更新日期:2009-01-01 00:00:00
abstract::Hallucinogenic drug-induced states are considered as models for acute schizophrenic disorders (experimental psychoses). In a double-blind study with healthy volunteers we investigated the influence of the serotonergic hallucinogen psilocybin, the ecstasy-like drug 3,4-methylenedioxyethylamphetamine (MDE), the stimulan...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000063672
更新日期:2002-01-01 00:00:00
abstract::Apomorphine, a dopamine receptor agonist (given in a dose of 0.75 mg s.c.), was administered to 8 healthy volunteers; electroencephalograph (EEG) and event-related potential (ERP) mapping were performed before dosing and 0.5, 1.5 and 2.5 h after dosing. Apomorphine caused an overall increase in beta activity at time 0...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000026560
更新日期:1999-01-01 00:00:00
abstract::Serotonergic dysfunction is implicated in Alzheimer's disease (AD) on the basis of studies of serotonin and its metabolite in postmortem specimens and CSF. There were also reports on association of a tryptophan hydroxylase (TPH) intron 7 variant and CSF 5-hydroxyindoleacetic acid concentrations. These suggested TPH mi...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000054856
更新日期:2001-01-01 00:00:00
abstract::Changes of field potentials electrically evoked from the mesencephalon were studied in two dopaminergic target areas. The modulation of the responses in prefrontal cortex and striatum induced by intravenous injection of various compounds influencing central dopaminergic transmission is followed. In general, drugs with...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118200
更新日期:1985-01-01 00:00:00
abstract::To clarify the role of the serotonergic system in limbic and thalamic epileptic activity, we examined the effects of 5-hydroxytryptophan (5-HTP, 20 and 40 mg/kg) on fully kindled seizures from the hippocampus and lateral geniculate nucleus. The intraperitoneal administration of 20 mg/kg 5-HTP exerted no anticonvulsant...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118813
更新日期:1992-01-01 00:00:00
abstract::Six WHO Collaborating Centre took part in the study of the antithymic activity of blood sera of patients suffering from schizophrenia. Blood serum specimens from 118 schizophrenic patients and 62 mentally healthy donors were investigated. Statistically significant differences between schizophrenic patients and the con...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117781
更新日期:1980-01-01 00:00:00
abstract::In contrast to the single-channel dimensional complexity, the global dimensional complexity is calculated from a multichannel EEG. The intention with the method is to measure the spatial distribution of information processing in the brain. The method seems to be of interest in psychopharmacological research, but the i...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119171
更新日期:1995-01-01 00:00:00
abstract::Spontaneous and drug-induced locomotor behavior was investigated in rats subjected to lesions of the ventral striatum, using the neurotoxin 6-hydroxydopamine to produce selective depletions of dopamine. Locomotor activity changed with time after lesion. At 2 weeks postoperative less spontaneous rearings were observed ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118311
更新日期:1986-01-01 00:00:00
abstract::Cortisol has a modulatory influence on cognitive functions in humans. Both impairing and enhancing effects of cortisol administration have been shown for hippocampus-dependent declarative memory, and impairing effects have been shown for prefrontal-cortex-dependent working memory function. Given the high density of gl...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000262180
更新日期:2010-01-01 00:00:00
abstract::REM sleep behavior disorder (RBD) is so far a possibly underestimated yet well-described sleep disorder. Its major impact is the vigorous sleep behavior that often results in injuries to the patient himself or to people sleeping nearby. We treated a 64-year-old male with a clinically and polysomnographically confirmed...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000119383
更新日期:1997-01-01 00:00:00
abstract::The serotonergic system has been implicated in the production of the N1 and P2 components of auditory evoked potentials (AEPs). Moreover, studies have indicated the influence of heritability in the genesis of these AEP components. The serotonin transporter is the major site of serotonin reuptake into the presynaptic n...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000065412
更新日期:2002-01-01 00:00:00
abstract::Schizophrenia is a heterogeneous and multidimensional disorder. The different syndromes or dimensions of this disorder represent distinct pathophysiological processes. Evidence is growing that each of the composite syndromes or dimensions of this disorder is associated with specific validators. This article reviewed n...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000119310
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Rasagiline and selegiline are classified as monoamine oxidase B (MAO-B) inhibitors. The present investigation deals with time-dependent electrical frequency changes (electropharmacograms) induced by these, as well as by aminoindan, the major metabolite of rasagiline. METHOD:Adult rats (day-night converted, ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000319947
更新日期:2010-01-01 00:00:00
abstract::A considerable proportion of chronic non-organic pain patients suffer from insomnia, and alpha sleep has been suggested to be specifically associated with fibromyalgia. However, the clinical significance of those symptoms is not clear. This study was carried out to investigate this question. Twenty-six middle-aged, no...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000054866
更新日期:2001-01-01 00:00:00
abstract::Clinical observations have suggested that lithium may exert adverse effects on memory. The difficulty in achieving empirical consensus regarding this issue has reflected several methodological problems: diversity of research designs, heterogeneous samples, lack of control groups and the possible confounding of memory ...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000118904
更新日期:1992-01-01 00:00:00
abstract::In humans and several other mammals, a quantitative EEG analysis has been used to study the regulation of sleep-wake behavior. In all mammalian species studied, cortical EEG recorded during non-REM sleep (NREMS) is characterized by the occurrence of spindles and high voltage, slow waves (0.5-4.0 Hz). Furthermore, slow...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000119017
更新日期:1993-01-01 00:00:00