Electroencephalographic characterization of brain dopaminergic stimulation by apomorphine in healthy volunteers.

Abstract:

:Apomorphine, a dopamine receptor agonist (given in a dose of 0.75 mg s.c.), was administered to 8 healthy volunteers; electroencephalograph (EEG) and event-related potential (ERP) mapping were performed before dosing and 0.5, 1.5 and 2.5 h after dosing. Apomorphine caused an overall increase in beta activity at time 0.5 h in both absolute and relative energy; P300 and CNV ERPs were not significantly altered, although a tendency towards increased P300 latency was seen. The results confirm that the EEG mapping technique is sufficiently sensitive to monitor dopaminergic neurochemical stimulation by means of apomorphine. This could lead to a new, non-invasive and repeatable method for monitoring central neuronal systems which is more convenient to apply repeatedly than for example positron emission tomography techniques. Furthermore, electrophysiological techniques undoubtedly constitute an alternative to classical neuroendocrinological methods, allowing a more direct assessment of central nervous system neurotransmission. Finally, these EEG approaches could lead to better characterization of drugs acting on dopaminergic pathways, such as antipsychotics.

journal_name

Neuropsychobiology

journal_title

Neuropsychobiology

authors

Luthringer R,Rinaudo G,Toussaint M,Bailey P,Muller G,Muzet A,Macher J

doi

10.1159/000026560

subject

Has Abstract

pub_date

1999-01-01 00:00:00

pages

49-56

issue

1

eissn

0302-282X

issn

1423-0224

pii

26560

journal_volume

39

pub_type

临床试验,杂志文章,随机对照试验
  • Statistical Decision Tree: a tool for studying pharmaco-EEG effects of CNS-active drugs.

    abstract::Quantitative pharmaco-EEG has become a useful technique for determining pharmacodynamic parameters after CNS-active drug administration. Nevertheless, one of the most important problems faced by practitioners of pharmaco-EEG is the difficulty in evaluating drug-specific effects. In this article, a methodology for comp...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000119068

    authors: Dago KT,Luthringer R,Lengellé R,Rinaudo G,Macher JP

    更新日期:1994-01-01 00:00:00

  • Exercise and mental health: many reasons to move.

    abstract::The relationship between physical activity and mental health has been widely investigated, and several hypotheses have been formulated about it. Specifically, during the aging process, physical exercise might represent a potential adjunctive treatment for neuropsychiatric disorders and cognitive impairment, helping de...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章,评审

    doi:10.1159/000223730

    authors: Deslandes A,Moraes H,Ferreira C,Veiga H,Silveira H,Mouta R,Pompeu FA,Coutinho ES,Laks J

    更新日期:2009-01-01 00:00:00

  • Schizophrenia susceptibility and HL-A antigen.

    abstract::The phenotype frequencies of HL-A specificities have been investigated in 47 chronic schizophrenics subdivided in an older and a younger group. The frequency of HL-A 9 was significantly increased in the psychotics as compared to a reference group of 1,263 healthy blood donors, pregnant women and potential kidney donor...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000117496

    authors: Eberhard G,Franzén G,Löw B

    更新日期:1975-01-01 00:00:00

  • FKBP5 Gene Variants May Modulate Depressive Features in Bipolar Disorder.

    abstract:BACKGROUND:Previous evidence suggested the possible association of FK506 binding protein 5 (FKBP5) gene variants in bipolar disorder (BPD). OBJECTIVE:Given the need of refinement of the findings obtained in large but poorly phenotyped samples, this study investigated the possible role of variants within FKBP5 in a sma...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000499976

    authors: Calabrò M,Crisafulli C,Di Nicola M,Colombo R,Janiri L,Serretti A

    更新日期:2019-01-01 00:00:00

  • Nonconvulsive status epilepticus during cephalosporin therapy.

    abstract::Cephalosporins may induce nonconvulsive status epilepticus (NCSE), a potentially reversible condition. Despite the wide use of these antibiotics, there are only few reported cases, because this condition is probably underestimated. We report two new cases of NCSE occurring during treatment with cefepime and ceftazidim...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000077370

    authors: Primavera A,Cocito L,Audenino D

    更新日期:2004-01-01 00:00:00

  • Receptor test (pupillary dilatation after application of 0.01% tropicamide solution) and determination of central nervous activation (Fourier analysis of pupillary oscillations) in patients with Alzheimer's disease.

    abstract::Memory loss and severe cognitive deficits in Alzheimer patients are supposed to be related to a reduction of acetylcholine as well as to central nervous deactivation. For the investigation of cholinergic deficits and deactivation, we used computer-assisted pupillometry. Cholinergic deficits caused by a particularly se...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000026595

    authors: Grünberger J,Linzmayer L,Walter H,Rainer M,Masching A,Pezawas L,Saletu-Zyhlarz G,Stöhr H,Grünberger M

    更新日期:1999-01-01 00:00:00

  • Influence of rapid tryptophan depletion on laboratory-provoked aggression in children with ADHD.

    abstract:BACKGROUND:The present study investigated the effects of rapid tryptophan depletion (RTD), and the ensuing reduction of central nervous system levels of serotonin (5-HT), upon reactive aggression in patients with attention deficit/hyperactivity disorder (ADHD). Furthermore, it was asked whether the relation between 5-H...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000112951

    authors: Stadler C,Zepf FD,Demisch L,Schmitt M,Landgraf M,Poustka F

    更新日期:2007-01-01 00:00:00

  • Phosphatidylserine: quantitative EEG effects in healthy volunteers.

    abstract::Eight healthy paid male volunteers (age: 21-28 years, mean: 24.5 +/- 1.7 years; weight 62-79 kg) were administered via intravenous infusion (3 min) acute 25-, 50-, and 75-mg doses of phosphatidylserine, or matching placebo in a latin-square design. Multichannel EEG recordings were performed in baseline conditions, dur...

    journal_title:Neuropsychobiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000119041

    authors: Rosadini G,Sannita WG,Nobili F,Cenacchi T

    更新日期:1990-01-01 00:00:00

  • Sensation seeking, sexual curiosity and testosterone in inmates.

    abstract::The relationships between sensation seeking, curiosity about sex, and total and free testosterone in inmates were investigated. The role of other hormones such as luteinizing hormone (LH), follicle-stimulating hormone (FSH), and sex hormone-binding globulin (SHBG) in these relationships was also analyzed. Previous ana...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000082852

    authors: Aluja A,García LF

    更新日期:2005-01-01 00:00:00

  • Repetitive Transcranial Magnetic Stimulation Improved Symptoms of Obsessive-Compulsive Disorder, but Also Cognitive Performance: Results from a Randomized Clinical Trial with a Cross-Over Design and Sham Condition.

    abstract:OBJECTIVE:There is some evidence that repetitive transcranial magnetic stimulation (rTMS) is an effective method of treating patients suffering from obsessive-compulsive disorder (OCD). Here, we tested the hypothesis that rTMS has a positive impact both on symptom severity and cognitive performance in such patients. Sp...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000446287

    authors: Jahangard L,Haghighi M,Shyayganfard M,Ahmadpanah M,Sadeghi Bahmani D,Bajoghli H,Holsboer-Trachsler E,Brand S

    更新日期:2016-01-01 00:00:00

  • Chronic, but not acute, clomipramine or fluoxetine treatment reduces the spontaneous firing rate in the mesoaccumbens neurons of the rat.

    abstract::In the present study, single-unit extracellular recording was used in male Wistar rats to compare the effects of a single dose (acute treatment) and a 21-day regimen (long-term treatment) with clomipramine (2.5 mg/kg) and fluoxetine (1.0 mg/kg) on the spontaneous firing rate of nucleus accumbens (NAcc) neurons connect...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000073627

    authors: Rodríguez-Landa JF,Contreras CM,Gutiérrez-García AG,Bernal-Morales B

    更新日期:2003-01-01 00:00:00

  • Evidence for a tetrahydrobiopterin deficit in schizophrenia.

    abstract::Tetrahydrobiopterin (BH(4)) is a vital cofactor maintaining availability of the amine neurotransmitters [dopamine (DA), noradrenaline (NA), and serotonin (5-HT)], regulating the synthesis of nitric oxide (NO) by nitric oxide synthase (NOS), and stimulating and modulating the glutamatergic system (directly and indirect...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000089002

    authors: Richardson MA,Read LL,Taylor Clelland CL,Reilly MA,Chao HM,Guynn RW,Suckow RF,Clelland JD

    更新日期:2005-01-01 00:00:00

  • Modulation of calcium and potassium currents by lamotrigine.

    abstract::Actions of the new antiepileptic drug lamotrigine (LTG) were characterized using extracellular and whole cell patch clamp recordings from rat CA1 and CA3 pyramidal cells in vitro. The results suggest that LTG, beside its previously described effect on the fast sodium inward current, also modulates - presumably voltage...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000026528

    authors: Grunze H,von Wegerer J,Greene RW,Walden J

    更新日期:1998-10-01 00:00:00

  • Adaptation to prismatic displacement by schizophrenics and normals.

    abstract::A sample of schizophrenic inpatients and a control sample of normal volunteers, matched for age and sex were tested on two tasks before and after an exposure condition in which they pointed repeatedly to a target while viewing their hands and the target through prisms. Both groups showed significant changes in both ta...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000117753

    authors: Pitblado C,Shapiro J,Petrides M

    更新日期:1980-01-01 00:00:00

  • Serum leptin and cholesterol values in suicide attempters.

    abstract::The growing number of studies examining the relationship between suicide and lipid metabolism are based upon studies suggesting that cholesterol-lowering procedures may increase the risk of death due to suicide or impulsive-aggressive behavior. Leptin seems to be strongly associated with lipid metabolism. In the prese...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000054950

    authors: Atmaca M,Kuloglu M,Tezcan E,Ustundag B,Gecici O,Firidin B

    更新日期:2002-01-01 00:00:00

  • Plasma 3,4-dihydroxyphenylethyleneglycol and therapeutic response to maprotiline and indalpine in major depression.

    abstract::Plasma levels of free and conjugated 3,4-dihydroxyphenylethyleneglycol (DOPEG), the main deaminated metabolite of norepinephrine, were assayed in 48 depressed patients before initiating a treatment with either maprotiline, an inhibitor of norepinephrine reuptake, or indalpine, a specific inhibitor of serotonin reuptak...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118243

    authors: Lôo H,Benkelfat C,Poirier MF,Vanelle JM,Olié JP,Dennis T,Scatton B

    更新日期:1986-01-01 00:00:00

  • Serum levels of carnitine in chronic fatigue syndrome: clinical correlates.

    abstract::Carnitine is essential for mitochondrial energy production. Disturbance in mitochondrial function may contribute to or cause the fatigue seen in chronic fatigue syndrome (CFS) patients. One previous investigation has reported decreased acylcarnitine levels in 38 CFS patients. We investigated 35 CFS patients (27 female...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000119226

    authors: Plioplys AV,Plioplys S

    更新日期:1995-01-01 00:00:00

  • Early visual processing over the menstrual cycle: the tilt aftereffect.

    abstract::We have previously shown that the tilt aftereffect (TAE) appears to respond to changes in central dopaminergic function. In this study, the TAE was investigated during the preovulatory and the premenstrual phases of the menstrual cycle. Results in the preovulatory phase mimicked those previously found associated with ...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000119484

    authors: Symons E,Calvert JE,Snelgar RS,Harris JP

    更新日期:1990-01-01 00:00:00

  • Schizophrenic patients who develop postoperative confusion have an increased norepinephrine and cortisol response to surgery.

    abstract::The purpose of this study was to investigate the relationship between postoperative confusion and the plasma norepinephrine (NE), adrenocorticotropin (ACTH) or cortisol response to surgery in schizophrenic patients. We studied 50 schizophrenic patients and 35 control patients who underwent orthopedic surgery and perio...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000063569

    authors: Kudoh A,Takahira Y,Katagai H,Takazawa T

    更新日期:2002-01-01 00:00:00

  • The control of blepharospasm by essential fatty acids.

    abstract::Dopamine depletion induced by administration of Ro4-1284 produces a condition of rapid and repeated eye blinking in rats. This condition mimics the human disorder, blepharospasm, which often accompanies parkinsonism and other dopamine deficiency disorders. When given a 3-week course of a compound (SR-3) developed from...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000026648

    authors: Mostofsky DI,Yehuda S,Rabinovitz S,Carasso R

    更新日期:2000-01-01 00:00:00

  • Effects of zolpidem and zaleplon on sleep, respiratory patterns and performance at a simulated altitude of 4,000 m.

    abstract::The effects of zolpidem or zaleplon on sleep architecture, respiratory patterns and performance were assessed at a simulated altitude of 4,000 m. Twelve male healthy subjects spent 4 nights in a decompression chamber, 1 at sea level (baseline), 3 at 4,000 m to test zolpidem (10 mg), zaleplon (10 mg) and placebo, given...

    journal_title:Neuropsychobiology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1159/000076723

    authors: Beaumont M,Batéjat D,Coste O,Van Beers P,Colas A,Clère JM,Piérard C

    更新日期:2004-01-01 00:00:00

  • Biochemical and diagnostic classification and serum drug levels: relation to antidepressive effect of imipramine.

    abstract::The relationship between clinical effect of imipramine (IP) in 39 depressed patients and biochemical distinction, serum drug levels, and diagnostic classification was investigated retrospectively. Based on pretreatment plasma ratios of tryptophan and tyrosine to competing amino acids, which reflect the availability of...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118182

    authors: Møller SE,Reisby N,Elley J,Krautwald O,Ortmann J,Larsen OB

    更新日期:1985-01-01 00:00:00

  • Serum dopamine-beta-hydroxylase in diagnostic subgroups of depressed patients and in relation to their personality characteristics.

    abstract::Serum dopamine-beta-hydroxylase (DBH) levels were assessed in 150 depressed patients of both sexes, with a mean age of 44.0 +/- 12.3 (SD) years. Patients were divided into unipolars (n = 46), bipolars (n = 25), neurotic-reactive (n = 46) and unspecified (n = 38) i.e., those who did not fit into any of the previous cat...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000117963

    authors: Eisemann M,Ericsson U,Von Knorring L,Perris C,Perris H,Ross S

    更新日期:1983-01-01 00:00:00

  • Cortisol responses of depressed children and adolescents to clonidine administration.

    abstract::The responses of cortisol to acute administration of saline and of clonidine (2.5 micrograms/kg B.W.) were examined in 10 children and adolescents with major depressive disorder and in 10 age- and sex-matched controls. Clonidine administration did not inhibit cortisol secretion in controls or in patients, contrary to ...

    journal_title:Neuropsychobiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000119022

    authors: Brambilla F,Guareschi-Cazzullo A,Musetti C,Nobile P,Tacchini C

    更新日期:1993-01-01 00:00:00

  • Less cognitive and neurological deficits in schizophrenia patients carrying risk variant in ZNF804A.

    abstract:BACKGROUND:The rs1344706 single nucleotide polymorphism in the ZNF804A gene is a common variant with strong evidence for association with schizophrenia. Recent studies show an association of rs1344706 with cognitive functioning, and there is some evidence suggesting that the risk allele may increase susceptibility for ...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000339731

    authors: Van Den Bossche MJ,Docx L,Morrens M,Cammaerts S,Strazisar M,Bervoets C,Smolders S,Depreeuw V,Lenaerts AS,De Rijk P,Del-Favero J,Sabbe BG

    更新日期:2012-01-01 00:00:00

  • Sydenham's chorea and psychosis.

    abstract::The medical histories of 600 psychotic and 369 nonpsychotic subjects were examined for the occurrence of rheumatic chorea. There was significantly more rheumatic chorea in the histories of psychotic patients than in nonpsychotics (p less than 0.01, chi-square). Neuropathological associations are discussed. ...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118234

    authors: Wilcox JA,Nasrallah HA

    更新日期:1986-01-01 00:00:00

  • Relation between plasma prolactin and plasma homovanillic acid in normal subjects.

    abstract::The relation between fasting, a.m. plasma prolactin and plasma/homovanillic acid (HVA) was studied in 9 healthy males on one occasion and in 9 healthy females on two occasions (in the follicular and luteal phase of the menstrual cycle). There was a significant inverse correlation between plasma HVA and plasma prolacti...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118303

    authors: Roy-Byrne PP,Rubinow DR,Linnoila M

    更新日期:1986-01-01 00:00:00

  • Lack of withdrawal signs of dependence following cessation of treatment or Ro-15,1788 administration to rats chronically treated with buspirone.

    abstract::Failure to gain weight during withdrawal from chronic regimens of dependence-producing drugs is observed in laboratory rats. Withdrawal from the benzodiazepine anxiolytic agent diazepam, whether induced by cessation of treatment or precipitated by administration of the specific benzodiazepine antagonist Ro-15,1788, is...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000118291

    authors: Eison MS

    更新日期:1986-01-01 00:00:00

  • Melatonin effects in a patient with severe REM sleep behavior disorder: case report and theoretical considerations.

    abstract::REM sleep behavior disorder (RBD) is so far a possibly underestimated yet well-described sleep disorder. Its major impact is the vigorous sleep behavior that often results in injuries to the patient himself or to people sleeping nearby. We treated a 64-year-old male with a clinically and polysomnographically confirmed...

    journal_title:Neuropsychobiology

    pub_type: 临床试验,杂志文章

    doi:10.1159/000119383

    authors: Kunz D,Bes F

    更新日期:1997-01-01 00:00:00

  • Relationship between plasma homovanillic acid and outcome in patients with psychosis spectrum disorders.

    abstract:BACKGROUND:Psychosis spectrum disorders, especially schizophrenia, have been linked to disturbed dopaminergic activity in the brain. Plasma homovanillic acid (pHVA) levels partly represent dopaminergic metabolism in the central nervous system. In the present study associations between (changes in) pHVA levels, symptom ...

    journal_title:Neuropsychobiology

    pub_type: 杂志文章

    doi:10.1159/000431095

    authors: van de Kerkhof NW,Fekkes D,van der Heijden FM,Egger JI,Verhoeven WM

    更新日期:2015-01-01 00:00:00