Abstract:
:REM sleep behavior disorder (RBD) is so far a possibly underestimated yet well-described sleep disorder. Its major impact is the vigorous sleep behavior that often results in injuries to the patient himself or to people sleeping nearby. We treated a 64-year-old male with a clinically and polysomnographically confirmed diagnosis of RBD with 3 mg melatonin, which led to a significant reduction of motor activity during sleep, as measured by actigraphy (p < 0.0001 in all analyzed movement parameters), and a full clinical recovery over a 5-month treatment period. RBD phenomena gradually returned after melatonin administration was stopped. After 2 months' treatment, polysomnography showed no major changes except an increase of REM sleep (13 vs. 17% of sleep period time) and a better preservation of REM-sleep-associated muscle atonia. Our results suggest that melatonin might be able to reinforce REM sleep in RBD patients by enhancing its active inhibition of motor activity.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Kunz D,Bes Fdoi
10.1159/000119383subject
Has Abstractpub_date
1997-01-01 00:00:00pages
211-4issue
4eissn
0302-282Xissn
1423-0224journal_volume
36pub_type
临床试验,杂志文章abstract::To examine volumetric abnormality, the caudate nucleus was measured in patients with schizophrenia and healthy subjects using magnetic resonance imaging. The absolute and relative volumes of white matter in the caudate nucleus were found to be significantly smaller in patients with schizophrenia compared to those in h...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000080956
更新日期:2004-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Apolipoprotein E (APOE) is polymorphic, and may be involved in the pathogenesis and clinical expression of schizophrenia. This study aimed to investigate the frequency of specific APOE genotypes and alleles in a schizophrenic Arab population and evaluate the association of specific APOE types with clinical p...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000236446
更新日期:2009-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000103573
更新日期:2007-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000118904
更新日期:1992-01-01 00:00:00
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journal_title:Neuropsychobiology
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更新日期:2020-07-14 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118893
更新日期:1992-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117945
更新日期:1983-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118303
更新日期:1986-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000054890
更新日期:2001-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117484
更新日期:1975-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000499976
更新日期:2019-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000087557
更新日期:2005-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000054856
更新日期:2001-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117908
更新日期:1982-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000079107
更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000089002
更新日期:2005-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118121
更新日期:1984-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Neuropsychobiology
pub_type: 杂志文章
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更新日期:1981-01-01 00:00:00
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journal_title:Neuropsychobiology
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journal_title:Neuropsychobiology
pub_type: 杂志文章
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更新日期:1986-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
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更新日期:1984-01-01 00:00:00
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更新日期:2004-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119182
更新日期:1995-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000098654
更新日期:2006-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000219304
更新日期:2009-01-01 00:00:00