Changes in the hypothalamic-pituitary-adrenal axis and leptin levels during antidepressant treatment.

Abstract:

BACKGROUND:In depressed patients, overstimulation of the hypothalamo-pituitary-adrenocortical (HPA) system, probably caused by glucocorticoid receptor resistance, is the most consistent neurobiological finding. Glucocorticoids themselves are reported to increase leptin synthesis and secretion in humans. METHODS:We examined alterations in plasma levels of leptin as well as changes in the HPA system function using the combined dexamethasone/corticotropin-releasing hormone (dex/CRH) test on admission and at discharge in 74 depressed inpatients. RESULTS:Mean leptin concentration did not change significantly between admission and discharge. However, changes in ACTH response and partial cortisol response to the combined dex/CRH test between admission and discharge were significantly correlated with leptin levels at discharge. CONCLUSIONS:Leptin levels at discharge rise as the HPA axis normalizes. These findings may be explained by an improvement in glucocorticoid receptor sensitivity among depressed patients during antidepressant therapy and a consecutively increased influence of glucocorticoids on leptin levels via the glucocorticoid receptor.

journal_name

Neuropsychobiology

journal_title

Neuropsychobiology

authors

Himmerich H,Zimmermann P,Ising M,Kloiber S,Lucae S,Kunzel HE,Binder EB,Holsboer F,Uhr M

doi

10.1159/000103573

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

28-35

issue

1

eissn

0302-282X

issn

1423-0224

pii

000103573

journal_volume

55

pub_type

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