Abstract:
:Clozapine is an effective atypical antipsychotic that has high affinity for many neurotransmitter receptors. Among the adverse effects of clozapine, urinary incontinence is commonly found and is suggested to be caused by alpha-adrenergic blockade. We tested the hypothesis that clozapine-induced urinary incontinence is related to a genetic variant of the alpha(1a)-adrenoceptor. We also tested whether the alpha(1a)-receptor gene confers susceptibility to schizophrenic disorders. Our result indicated that the alpha(1a)-adrenoceptor gene polymorphism investigated plays no major role in the pathogenesis of schizophrenia or in clozapine-induced urinary incontinence. Considering the superior effects of clozapine and its potent adrenergic antagonistic effects, it is of interest to investigate the association between this polymorphism and the treatment response.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Hsu JW,Wang YC,Lin CC,Bai YM,Chen JY,Chiu HJ,Tsai SJ,Hong CJdoi
10.1159/000026674keywords:
subject
Has Abstractpub_date
2000-01-01 00:00:00pages
62-5issue
2eissn
0302-282Xissn
1423-0224pii
26674journal_volume
42pub_type
临床试验,杂志文章abstract:BACKGROUND:Apolipoprotein E (APOE) is polymorphic, and may be involved in the pathogenesis and clinical expression of schizophrenia. This study aimed to investigate the frequency of specific APOE genotypes and alleles in a schizophrenic Arab population and evaluate the association of specific APOE types with clinical p...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000236446
更新日期:2009-01-01 00:00:00
abstract::Cerebral impedance changes (F changes) indicating cerebral blood flow variations in the central and precentral areas were measured with a rheographic technique in normal subjects preparing for and carrying out a motor task. The time course of the F changes was studied and several significant correlations were establis...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117609
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:Abnormalities in different parameters of the norepinephrine system have been widely described in major depression. The presence of alpha(2)-adrenoreceptors in blood platelets, similar to those in the brain, prompted us to evaluate them in depressed patients, as compared with healthy controls. METHODS:Fiftee...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000054930
更新日期:2001-01-01 00:00:00
abstract:AIMS:The aim was to measure the prefrontal cortical activity involved in shifting spatial attention to visual stimuli in the left or right visual field using near-infrared spectroscopy. METHODS:Eleven participants performed a simple vigilance task, an endogenous attention task and an exogenous attention task. In the e...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000159773
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:The present study investigated the effects of rapid tryptophan depletion (RTD), and the ensuing reduction of central nervous system levels of serotonin (5-HT), upon reactive aggression in patients with attention deficit/hyperactivity disorder (ADHD). Furthermore, it was asked whether the relation between 5-H...
journal_title:Neuropsychobiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000112951
更新日期:2007-01-01 00:00:00
abstract::In the present study, single-unit extracellular recording was used in male Wistar rats to compare the effects of a single dose (acute treatment) and a 21-day regimen (long-term treatment) with clomipramine (2.5 mg/kg) and fluoxetine (1.0 mg/kg) on the spontaneous firing rate of nucleus accumbens (NAcc) neurons connect...
journal_title:Neuropsychobiology
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doi:10.1159/000073627
更新日期:2003-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000103905
更新日期:2007-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000488893
更新日期:2017-01-01 00:00:00
abstract::The early research on an animal (cat) model and biological marker (visual evoked potential augmenting and reducing) of sensation seeking behavior is briefly described. Recent findings with selectively bred lines of rats show that (1) the relationship between sensation seeking behavior and augmenting vs. reducing is al...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000119304
更新日期:1996-01-01 00:00:00
abstract::The acute effects of alcohol (0.7 g/kg) on visual signal detection performance and critical flicker fusion frequency (CFF) of normal volunteers were investigated using a signal detection theory analysis. When signal probability was low, alcohol affected the stimulus sensitivity and the reaction times of hits. Under a ...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000118209
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND/AIMS:Neurotrophins such as brain-derived neurotrophic factor (BDNF) are vital for neuronal survival and adaptive plasticity. With high BDNF gene expression in the prefrontal cortex, BDNF is a potential regulatory factor for building and maintaining cognitive reserves. Recent studies suggest that individual d...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000362242
更新日期:2014-01-01 00:00:00
abstract::Abnormal anterior pituitary responsiveness to acute administration of thyrotropin-releasing hormone was investigated in 8 patients, 6 women and 2 men, with primary affective disorders in a depressive phase and in 2 women with schizoaffective disorders. Thyrotropin-releasing hormone, 500 micrograms i.v., induced a rise...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117908
更新日期:1982-01-01 00:00:00
abstract::Regular repetition of one monitor of sensory perception and another of psychomotor perception revealed similar frequency and amplitude aspects of spontaneous endogenous free-running cycles of perception and others of vigilance. The ultradian periodicities of these cycles distinguish between persons with intact nervous...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117499
更新日期:1975-01-01 00:00:00
abstract::Besides their regulation of the pituitary-adrenal and pituitary-thyroidal axis, respectively, the neurohormones CRH and TRH act within the central nervous system to evoke and modulate a number of behavioral and physiological processes. In particular, an increase in the sympathetic nervous system and respiratory activi...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000119000
更新日期:1993-01-01 00:00:00
abstract::A double-blind comparison of zimeldine, a selective 5-HT reuptake inhibitor, and nomifensine, a noradrenaline and a dopamine reuptake inhibitor, was carried out in 43 inpatients with a scheduled treatment period of 6 weeks. All patients were diagnosed as definite major depressive disorder according to Research Diagnos...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000118086
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Rasagiline and selegiline are classified as monoamine oxidase B (MAO-B) inhibitors. The present investigation deals with time-dependent electrical frequency changes (electropharmacograms) induced by these, as well as by aminoindan, the major metabolite of rasagiline. METHOD:Adult rats (day-night converted, ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000319947
更新日期:2010-01-01 00:00:00
abstract::Hallucinogenic drug-induced states are considered as models for acute schizophrenic disorders (experimental psychoses). In a double-blind study with healthy volunteers we investigated the influence of the serotonergic hallucinogen psilocybin, the ecstasy-like drug 3,4-methylenedioxyethylamphetamine (MDE), the stimulan...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000063672
更新日期:2002-01-01 00:00:00
abstract::Previously, we performed an MRI study that revealed smaller volumes of the subregions of the cerebellar vermis in men and women with chronic schizophrenia. An issue that arose from that study was whether similar structural changes in the cerebellum are found in patients with first-episode schizophrenia. In the present...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000122268
更新日期:2007-01-01 00:00:00
abstract::The brain activity of 13 right-handed students (6 men and 7 women) was determined using high resolution (99m)Tc-HMPAO brain SPECT images during visuospatial tasks. The results showed that there was no significant gender-specific difference in solving the visuospatial tasks and that no meaningful statistical difference...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026639
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Considerable evidence suggests that variation of the serotonin-transporter-linked promoter region (5- HTTLPR) is associated with anxiety-related traits. Academic outcomes are also more closely related to trait anxiety. This preliminary study aimed to explore the association between academic performance and l...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000317550
更新日期:2011-01-01 00:00:00
abstract::Performance on temporal discrimination of time intervals in the range of milliseconds is interpreted by the assumption of an internal clock; the higher the clock rate the better the temporal resolution of the internal clock will be, which is equivalent to more accuracy in timing of brief intervals. Although there is s...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000118899
更新日期:1992-01-01 00:00:00
abstract::Knowledge in neuropsychobiology continues to benefit from the use of drugs as 'tools' to alter neurochemical events as a means of studying interactions between the events and behaviour. Before drugs could play such a role, concepts about basic properties of living organism had to be refined. Techniques had to be inven...
journal_title:Neuropsychobiology
pub_type: 历史文章,杂志文章
doi:10.1159/000118407
更新日期:1987-01-01 00:00:00
abstract::Serum dopamine-beta-hydroxylase (DBH) levels were assessed in 150 depressed patients of both sexes, with a mean age of 44.0 +/- 12.3 (SD) years. Patients were divided into unipolars (n = 46), bipolars (n = 25), neurotic-reactive (n = 46) and unspecified (n = 38) i.e., those who did not fit into any of the previous cat...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117963
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND/AIMS:Valproic acid or valproate (VA) is an anticonvulsant and mood-stabilizing drug primarily used in the treatment of epilepsy and bipolar disorder. Ziprasidone (ZPN) is an atypical antipsychotic drug used mainly for the treatment of schizophrenia. METHODS:This study is a part of our investigation on the c...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000327604
更新日期:2011-01-01 00:00:00
abstract::We agree with the conclusions of a recent article in this journal [James, Neuropsychobiology 1994;30:124-125] that studies on the psychoactive effects of caffeine need to take into account the possibility that the results obtained might represent merely the reversal of deleterious effects of caffeine deprivation rathe...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000119192
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:There is some evidence that repetitive transcranial magnetic stimulation (rTMS) is an effective method of treating patients suffering from obsessive-compulsive disorder (OCD). Here, we tested the hypothesis that rTMS has a positive impact both on symptom severity and cognitive performance in such patients. Sp...
journal_title:Neuropsychobiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000446287
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:There is increasing evidence that altered immune responses play a role in the pathogenesis of autism spectrum disorders (ASD), together with dysfunction of the serotonergic and glutamatergic systems. Since the kynurenine (KYN) pathway that degrades tryptophan (TRP) is activated in various neuroinflammatory s...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000488157
更新日期:2017-01-01 00:00:00
abstract::Based on 5-HT hypothesis, L-5-HTP (150 or 300 mg/day) was given orally to 18 depressed patients. The global estimates were 2 very much improved; 8 much improved; 3 minimally improved, and 5 unchanged. The action of L-5-HTP was usually rapid. The elevation of the serum 5-HT level 1 week after L-5-HTP administration was...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117687
更新日期:1979-01-01 00:00:00
abstract::An auditory event-related potential paradigm was designed to objectively quantify the effects of drugs on the central nervous system (CNS). A series of tones was presented at three random interstimulus intervals (ISI). The amplitude of N1-P2 and the recovery of this complex across ISI appear to be rapid, reliable and ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118715
更新日期:1990-01-01 00:00:00
abstract::Twenty-seven medicated chronic schizophrenic female patients were tested for right or left turning behavior. No substantial right or left asymmetry was found, nor did the addition of the indirect dopaminergic agonist amantadine influence these results. Previous studies demonstrated left circling preference in chronic ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119355
更新日期:1997-01-01 00:00:00