Cerebellar posterior superior vermis and cognitive cluster scores in drug-naive patients with first-episode schizophrenia.

Abstract:

:Previously, we performed an MRI study that revealed smaller volumes of the subregions of the cerebellar vermis in men and women with chronic schizophrenia. An issue that arose from that study was whether similar structural changes in the cerebellum are found in patients with first-episode schizophrenia. In the present study, MRI scans were acquired from 14 drug-naive patients with first-episode schizophrenia and 16 healthy subjects, and used to measure the volumes of their cerebellar subregions. Positive symptom, negative symptom and cognitive cluster scores were attained using the Positive and Negative Syndrome Scale. Patients with first-episode schizophrenia had reduced volumes of the anterior vermis and posterior superior vermis compared with healthy subjects. We confirmed that there was a volume reduction of the cerebellar vermis in drug-naive patients with first-episode schizophrenia. Smaller volumes of the posterior superior vermis were associated with worse cognitive cluster scores in patients with first-episode schizophrenia.

journal_name

Neuropsychobiology

journal_title

Neuropsychobiology

authors

Okugawa G,Nobuhara K,Takase K,Kinoshita T

doi

10.1159/000122268

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

216-9

issue

4

eissn

0302-282X

issn

1423-0224

pii

000122268

journal_volume

56

pub_type

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