Abstract:
:The author contended opposite pharmacological effects resulting from lithium and amphetamine. Three groups, each one consisting of four rats, were put on chronic lithium condition to measure its effects on amphetamine hyperactivity. This condition was effected after appropriate handling and saline control periods and the baselines for drug activity were measured. In young rats (150-200g), lithium significantly decreased d-amphetamine hyperactivity (and probably other effects, like anorexia) while producing little effect on amphetamine stereotyped behavior (ASB). If confirmed, this fact may prove of marked importance in further localizing and studying the pharmacology of lithium. However, this observation was true in only three rats of the first group. All other rats, of the older group or of the other strain, showed only ASB, a fact that also deserves further study because it seems to contradict previous important reports.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Flemenbaum Adoi
10.1159/000117509keywords:
subject
Has Abstractpub_date
1975-01-01 00:00:00pages
325-34issue
6eissn
0302-282Xissn
1423-0224journal_volume
1pub_type
杂志文章abstract:BACKGROUND AND AIMS:Time of onset of antipsychotic action is still a debated matter. We aimed to replicate and extend previous findings that early response can predict subsequent non-response. METHODS:86 acutely psychotic patients treated with haloperidol were studied. RESULTS:A PANSS reduction ≤16% at 1 week predict...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000337739
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:In depressed patients, overstimulation of the hypothalamo-pituitary-adrenocortical (HPA) system, probably caused by glucocorticoid receptor resistance, is the most consistent neurobiological finding. Glucocorticoids themselves are reported to increase leptin synthesis and secretion in humans. METHODS:We exa...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000103573
更新日期:2007-01-01 00:00:00
abstract::In the search for differential mechanisms underlying clozapine's superior antipsychotic efficacy, the purinergic system has been considered, since an antagonist of the adenosine receptor A(2A) was shown to block clozapine acute effects on c-fos expression in rat striatum. Further investigating the interaction of cloza...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000054925
更新日期:2001-01-01 00:00:00
abstract::This paper reports a replication study of a four-group cluster-analytic typology of depressed patients. Several hierarchial agglomerative clustering procedures were applied on the original patient sample using a slightly reduced variable pool. The best replication obtained used Ward's error sum of squares method and w...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117595
更新日期:1977-01-01 00:00:00
abstract::In humans and several other mammals, a quantitative EEG analysis has been used to study the regulation of sleep-wake behavior. In all mammalian species studied, cortical EEG recorded during non-REM sleep (NREMS) is characterized by the occurrence of spindles and high voltage, slow waves (0.5-4.0 Hz). Furthermore, slow...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000119017
更新日期:1993-01-01 00:00:00
abstract::Electrovestibulography (EVestG) recordings have been previously applied toward classifying and/or measuring the severity of several neurological disorders including depression with and without anxiety. This study's objectives were to: (1) extract EVestG features representing physiological differences of healthy women ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000487771
更新日期:2017-01-01 00:00:00
abstract::The region coding human leukocyte antigen (HLA) on chromosome 6q21 was shown to be associated with both the vulnerability to schizophrenia and presence of eye movement disturbances (EMD). The aim of this preliminary study was to investigate how individual class I and II HLA antigens in schizophrenic patients may be re...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000085595
更新日期:2005-01-01 00:00:00
abstract::Cerebral impedance changes (F changes) indicating cerebral blood flow variations in the central and precentral areas were measured with a rheographic technique in normal subjects preparing for and carrying out a motor task. The time course of the F changes was studied and several significant correlations were establis...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117609
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:This study aimed to compare the effects of aerobic training (AT), strength training (ST) and low-intensity exercise in a control group (CG) as adjunct treatments to pharmacotherapy for major depressive disorder (MDD) in older persons. METHODS:Older persons clinically diagnosed with MDD (n = 27) and treated ...
journal_title:Neuropsychobiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000503750
更新日期:2020-01-01 00:00:00
abstract::The genotypes of the CYP2E1 loci of 35 alcoholic and 130 nonalcoholic (healthy controls) Japanese were investigated to determine the relationship between CYP2E1 (C/D) polymorphism and susceptibility to alcohol dependence. There was a significant (d.f. = 1, chi2 = 11.0, p < 0.001) difference in the CYP2E1 C gene freque...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000026544
更新日期:1998-11-01 00:00:00
abstract::The new anticonvulsant, lamotrigine, is becoming an important tool in the treatment of bipolar disorder, including bipolar depression. Its efficacy in bipolar depression might be linked to its inhibition of serotonin uptake. We present the case of a female schizoaffective patient successfully treated with 400 mg of la...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026538
更新日期:1998-10-01 00:00:00
abstract:AIM:We describe the difficulties encountered in making a diagnosis where a somatic condition manifests itself alongside psychiatric symptoms associated with possible psychiatric comorbidities. METHODS:A case study is presented of a 15-year-old girl who was eventually diagnosed with ornithine transcarbamylase (OTC) def...
journal_title:Neuropsychobiology
pub_type:
doi:10.1159/000508679
更新日期:2020-07-20 00:00:00
abstract::Male Wistar rats were able to drink water and different percentages of ethyl alcohol in a free-choice paradigm. Our results showed a clear-cut preference for 2 and 3% ethanol concentration. Addition of quinine in both drinking bottles increased preference for alcohol, while dilution of saccharin in both bottles totall...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118113
更新日期:1984-01-01 00:00:00
abstract::Apomorphine, a dopamine receptor agonist (given in a dose of 0.75 mg s.c.), was administered to 8 healthy volunteers; electroencephalograph (EEG) and event-related potential (ERP) mapping were performed before dosing and 0.5, 1.5 and 2.5 h after dosing. Apomorphine caused an overall increase in beta activity at time 0...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000026560
更新日期:1999-01-01 00:00:00
abstract::The relationship between physical activity and mental health has been widely investigated, and several hypotheses have been formulated about it. Specifically, during the aging process, physical exercise might represent a potential adjunctive treatment for neuropsychiatric disorders and cognitive impairment, helping de...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000223730
更新日期:2009-01-01 00:00:00
abstract::Suicide is a major problem for psychiatry. Depression is the most common mental disorder related to suicidal behavior. The present study aimed at investigating the relationship between the symptomatology related to death, dying, and suicide and neurobiological factors in depressed patients. Fifty patients aged 21-60 y...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000075338
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Psychosis spectrum disorders, especially schizophrenia, have been linked to disturbed dopaminergic activity in the brain. Plasma homovanillic acid (pHVA) levels partly represent dopaminergic metabolism in the central nervous system. In the present study associations between (changes in) pHVA levels, symptom ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000431095
更新日期:2015-01-01 00:00:00
abstract::Somatosensory event-related potentials (SERP) were recorded in 30 chronic young schizophrenic patients and in 15 age-matched controls. Objective SERP parameters were latencies, amplitudes and the determination of areas of the cognitive components N1 and P3 by integration. Highly significantly reduced areas and prolong...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118568
更新日期:1989-01-01 00:00:00
abstract::Piracetam, when applied microiontophoretically and/or by hydropneumatic pump on the somatosensory cortex and hippocampus of the rat, affected neuronal activity by depressing or facilitating the spontaneous firing rate, depending on the area studied. Its effect were either additive or counteracting the actions of gluta...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118449
更新日期:1988-01-01 00:00:00
abstract::The responses of cortisol to acute administration of saline and of clonidine (2.5 micrograms/kg B.W.) were examined in 10 children and adolescents with major depressive disorder and in 10 age- and sex-matched controls. Clonidine administration did not inhibit cortisol secretion in controls or in patients, contrary to ...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000119022
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Oxytocin interacts with the dopaminergic system, which plays a role in addiction behaviors. The association between oxytocin and addiction was confirmed in animal studies. Novelty seeking is one of the predictors and indicators of drug addiction. The aim of the present study was to probe the association betw...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000371637
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:eLORETA (exact low-resolution brain electromagnetic tomography) is a technique created by Pascual-Marqui et al. [Int J Psychophysiol. 1994 Oct; 18(1): 49-65] for the 3-dimensional representation of current source density in the brain by electroencephalography (EEG) data. Kurtosis analysis allows for the iden...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000495522
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND/AIMS:Neurotrophins such as brain-derived neurotrophic factor (BDNF) are vital for neuronal survival and adaptive plasticity. With high BDNF gene expression in the prefrontal cortex, BDNF is a potential regulatory factor for building and maintaining cognitive reserves. Recent studies suggest that individual d...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000362242
更新日期:2014-01-01 00:00:00
abstract:INTRODUCTION:REM sleep behavior disorder (RBD) is considered a prodromal phase of α-synucleinopathy like Parkinson disease (PD). PD is characterized by a progressive decline of dopamine (DA) in the striatum. Here we report the surprising increase in DA transporter density over successive years in an RBD patient treated...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000488893
更新日期:2017-01-01 00:00:00
abstract::Little is known about the effects of cocaine on cognitive tasks. Event-related potentials (ERP) were recorded in 7 cocaine abusers during the performance of the auditory oddball task before and after the intravenous injections of saline and cocaine (60-80 mg). The P3B and slow wave components of the ERP were significa...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000119148
更新日期:1994-01-01 00:00:00
abstract::In the present study, single-unit extracellular recording was used in male Wistar rats to compare the effects of a single dose (acute treatment) and a 21-day regimen (long-term treatment) with clomipramine (2.5 mg/kg) and fluoxetine (1.0 mg/kg) on the spontaneous firing rate of nucleus accumbens (NAcc) neurons connect...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000073627
更新日期:2003-01-01 00:00:00
abstract::Fengabine is a new GABAmimetic compound active in animal models predictive of antidepressant activity. The present overview reports the results of 6 double-blind trials versus tricyclics (TCAs) (3 in outpatients and 3 in inpatients). Overall, 398 adult patients (149 males and 249 females) were treated; 194 with fengab...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000118485
更新日期:1989-01-01 00:00:00
abstract::Serum dopamine-beta-hydroxylase (DBH) levels were assessed in 150 depressed patients of both sexes, with a mean age of 44.0 +/- 12.3 (SD) years. Patients were divided into unipolars (n = 46), bipolars (n = 25), neurotic-reactive (n = 46) and unspecified (n = 38) i.e., those who did not fit into any of the previous cat...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117963
更新日期:1983-01-01 00:00:00
abstract::The serotonergic system has been implicated in the production of the N1 and P2 components of auditory evoked potentials (AEPs). Moreover, studies have indicated the influence of heritability in the genesis of these AEP components. The serotonin transporter is the major site of serotonin reuptake into the presynaptic n...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000065412
更新日期:2002-01-01 00:00:00
abstract::Angiotensin-converting enzyme (ACE) is a key enzyme in the renin-angiotensin system and can modulate dopamine turnover in the midbrain. Previous studies have revealed changes in the central ACE levels for schizophrenic patients, possibly related to the polydipsia commonly demonstrated for chronic schizophrenia. An ins...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000054911
更新日期:2001-01-01 00:00:00