Association study of angiotensin-converting enzyme gene polymorphism with schizophrenia and polydipsia.

Abstract:

:Angiotensin-converting enzyme (ACE) is a key enzyme in the renin-angiotensin system and can modulate dopamine turnover in the midbrain. Previous studies have revealed changes in the central ACE levels for schizophrenic patients, possibly related to the polydipsia commonly demonstrated for chronic schizophrenia. An insertion (I)/deletion (D) polymorphism of the ACE gene has been associated with ACE levels. Therefore, we elected to investigate the ACE I/D polymorphism for 124 schizophrenic patients and 117 control subjects. No significant differences for the genotype distribution or the allele frequency were revealed comparing controls and schizophrenic patients. The ACE genotypes were not associated with onset age or psychiatric symptoms for the schizophrenic cases. A modest association was revealed for this ACE polymorphism and polydipsia diagnosis for these patients. Using bearers of the D allele as baseline, the ratio for I/I homozygote was 2.31 (95% CI 0.95-5.65). This association needs further replication as it may have implications for the pathogenesis and the treatment of polydipsia for schizophrenic patients.

journal_name

Neuropsychobiology

journal_title

Neuropsychobiology

authors

Ouyang WC,Wang YC,Hong CJ,Cheng CY,Tsai SJ

doi

10.1159/000054911

keywords:

subject

Has Abstract

pub_date

2001-01-01 00:00:00

pages

31-5

issue

1

eissn

0302-282X

issn

1423-0224

pii

54911

journal_volume

44

pub_type

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