Abstract:
:Renal lithium clearance and the serum lithium levels following a single oral loading dose of lithium were used as measures to predict lithium dose requirement during long-term maintenance at 3 different psychiatric centers in North America. Saliva lithium values were also investigated at one of the centers. The correlation between lithium clearance and the 17-hour serum lithium level, and subsequent dosage was high; the mean correlation co-efficient from the 3 centers being 0.84 for renal lithium clearance and 0.75 for both the 17-hour and 10-hour serum lithium levels. These tests can therefore be recommended as a guide to estimate lithium dose requirement in patients starting lithium maintenance treatment although absolute reliance should not be placed on the prediction formulae obtained. The correlation between saliva lithium and eventual dosage was poor and of little predictive value.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Tyrer SP,Grof P,Kalvar M,Shopsin Bdoi
10.1159/000117844subject
Has Abstractpub_date
1981-01-01 00:00:00pages
152-8issue
3eissn
0302-282Xissn
1423-0224journal_volume
7pub_type
杂志文章abstract::The focus is on evaluating the relationships between early behavioural problems and biochemical variables at adult age and their significance for early criminality and violent behaviour in a life perspective. In the present study, using prospective longitudinal data, a sample of males with a history of early criminal ...
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章
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更新日期:2003-01-01 00:00:00
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更新日期:1977-01-01 00:00:00
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更新日期:1995-01-01 00:00:00
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