Abstract:
:It is known that P-4502E1 metabolizes both ethanol and acetaldehyde, and that it can be induced after birth by inducers such as ethanol. Genetic polymorphisms in the 5'-flanking region change its transcriptional regulation. Persons who are either hetereozygous or mutant homozygous for CYP2E1 (C1/C2 or C2/C2) can drink much more alcohol than persons who are normal homozygous for CYP2E1 (C1/C1) among those whose aldehyde dehydrogenase 2 genotype is heterozygous. Subjects were composed of 52 Japanese alcoholics. The alcoholics having no C2 (group 1) and the alcoholics having C2 (group 2) were compared with each other with respect to their clinical characteristics: family history, past history, alcohol-related symptoms, complications, social disabilities, self-consciousness and short alcohol dependence date. In the social disabilities, the genotypes of CYP2E1 (C1/C2 or C2/C2) showed significantly more cases of guilts (p < 0.05). In regard to liver disease or self-consciousness, this was at a trend level (p = 0.08). We have shown that the genotypes of CYP2E1 are associated with clinical features of alcoholics.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Nakamura K,Iwahashi K,Ameno K,Sekine Y,Suzuki K,Minabe Y,Mori Ndoi
10.1159/000070014keywords:
subject
Has Abstractpub_date
2003-01-01 00:00:00pages
86-9issue
2eissn
0302-282Xissn
1423-0224pii
70014journal_volume
47pub_type
杂志文章abstract:INTRODUCTION:Research into the significance of early subjective response to antipsychotic medication has so far only involved observation periods of up to 1 year. METHOD:The Drug Attitude Inventory (DAI-10) questionnaires, completed by patients with the diagnosis of schizophrenia in 1997-1998, were the bases for this ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000339092
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:The polymorphisms of serotonergic genes (5-HTTLPR and HTR1A rs6295) and separation life events have been studied to find an association with panic disorder, respectively. However, there are no studies that have yet evaluated the interaction effect between serotonergic genes and separation life events for pan...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000347084
更新日期:2013-01-01 00:00:00
abstract::Behavioral abnormalities, jumping reaction, increase in spontaneous activity abnormal violence, and lethargy were observed in long-term ultraviolet A (UVA)-irradiated hairy male Crj:CD-1 mice. The learning ability of 6- and 12-months UVA-irradiated mice was significantly reduced compared to un-irradiated age-matched m...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119274
更新日期:1996-01-01 00:00:00
abstract::Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine and these neurotransmitters are hypothesized to be involved in the cognitive function of humans. This study of a cohort of 191 healthy young Chinese females attempts to utilize the intelligence qu...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000086609
更新日期:2005-01-01 00:00:00
abstract::Single, 50- and 100-mg oral doses of phenobarbital and a matching placebo were administered double-blind to 8 young, healthy male subjects. Multilead electroencephalographic (EEG) samples were recorded prior to, and at regular intervals within the 2 h following administration. The EEG signal was processed by power spe...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000119453
更新日期:1990-01-01 00:00:00
abstract::In contrast to the single-channel dimensional complexity, the global dimensional complexity is calculated from a multichannel EEG. The intention with the method is to measure the spatial distribution of information processing in the brain. The method seems to be of interest in psychopharmacological research, but the i...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119171
更新日期:1995-01-01 00:00:00
abstract::The effects of the dopaminergic agonists (L-dopa, pergolide) and antagonists (haloperidol, clozapin) and a cholinergic agonist (tacrine) and antagonist (mecamylamine) on the voluntary intake of nicotine were investigated with the 2-bottle paradigm with the test drugs being dissolved directly in the drinking fluid of t...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026661
更新日期:2000-01-01 00:00:00
abstract::A double-blind comparison of zimeldine, a selective 5-HT reuptake inhibitor, and nomifensine, a noradrenaline and a dopamine reuptake inhibitor, was carried out in 43 inpatients with a scheduled treatment period of 6 weeks. All patients were diagnosed as definite major depressive disorder according to Research Diagnos...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000118086
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:Derangements of the gut microbiome have been linked to increased systemic inflammation and central nervous system disorders, including schizophrenia. This systematic review thus aimed to investigate the hypothesis that probiotic supplementation improves schizophrenia symptoms. METHODS:By using the keywords ...
journal_title:Neuropsychobiology
pub_type: 杂志文章,meta分析
doi:10.1159/000498862
更新日期:2019-01-01 00:00:00
abstract::Little information exists on the concentrations of recent antidepressants and their metabolites in cerebrospinal fluid (CSF). Using a stereoselective method, we measured plasma and CSF levels of mirtazapine (MIR), N-demethylmirtazapine and 8-OH-MIR in 3 depressed patients treated with racemic MIR (45 mg/day) for 4 wee...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000098654
更新日期:2006-01-01 00:00:00
abstract::Little is known about the effects of cocaine on cognitive tasks. Event-related potentials (ERP) were recorded in 7 cocaine abusers during the performance of the auditory oddball task before and after the intravenous injections of saline and cocaine (60-80 mg). The P3B and slow wave components of the ERP were significa...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000119148
更新日期:1994-01-01 00:00:00
abstract::REM sleep behavior disorder (RBD) is so far a possibly underestimated yet well-described sleep disorder. Its major impact is the vigorous sleep behavior that often results in injuries to the patient himself or to people sleeping nearby. We treated a 64-year-old male with a clinically and polysomnographically confirmed...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000119383
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Although differences in symptom profiles and outcome between depressive patients with an underlying major depressive disorder (MDD) and bipolar depression (BD) have been reported, studies with sequential short-interval assessments in a real-life inpatient setting are scarce. OBJECTIVES:To examine potential ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000503686
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Apolipoprotein E (APOE) is polymorphic, and may be involved in the pathogenesis and clinical expression of schizophrenia. This study aimed to investigate the frequency of specific APOE genotypes and alleles in a schizophrenic Arab population and evaluate the association of specific APOE types with clinical p...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000236446
更新日期:2009-01-01 00:00:00
abstract:AIM:We describe the difficulties encountered in making a diagnosis where a somatic condition manifests itself alongside psychiatric symptoms associated with possible psychiatric comorbidities. METHODS:A case study is presented of a 15-year-old girl who was eventually diagnosed with ornithine transcarbamylase (OTC) def...
journal_title:Neuropsychobiology
pub_type:
doi:10.1159/000508679
更新日期:2020-07-20 00:00:00
abstract:OBJECTIVE:Schizophrenia, a common neurological disorder appearing in the late teens or early adulthood, is characterized by disorganized thinking, behaviour, and perception of emotions. Aberrant N-methyl-D-aspartate (NMDA) receptor-mediated synaptic plasticity is a major pathological event here due to dysfunction of do...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000454985
更新日期:2016-01-01 00:00:00
abstract::In the present study, the effects of short-acting benzodiazepines on nocturnal sleep and the carryover effects of these drugs were studied. The study involved 10 young, healthy male subjects who had given their written informed consent to participate. Either a placebo (PLA), 0.125 mg triazolam (TRZ), 0.25 mg TRZ or 0....
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000070586
更新日期:2003-01-01 00:00:00
abstract::The genotypes of the CYP2E1 loci of 35 alcoholic and 130 nonalcoholic (healthy controls) Japanese were investigated to determine the relationship between CYP2E1 (C/D) polymorphism and susceptibility to alcohol dependence. There was a significant (d.f. = 1, chi2 = 11.0, p < 0.001) difference in the CYP2E1 C gene freque...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000026544
更新日期:1998-11-01 00:00:00
abstract::Eight healthy paid male volunteers (age: 21-28 years, mean: 24.5 +/- 1.7 years; weight 62-79 kg) were administered via intravenous infusion (3 min) acute 25-, 50-, and 75-mg doses of phosphatidylserine, or matching placebo in a latin-square design. Multichannel EEG recordings were performed in baseline conditions, dur...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000119041
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND/AIMS/METHODS:Electroconvulsive therapy (ECT) is still one of the most potent treatments in the acute phase of major depressive disorder (MDD) and particularly applied in patients considered treatment resistant. However, despite the frequent and widespread use of ECT for >70 years, the exact neurobiological m...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000505553
更新日期:2020-01-01 00:00:00
abstract::Like the industry, the medical profession takes now an interest in quality assurance programs. In the field of psychiatry, the quality assessment of antidepressive drug prescriptions is an ideal target. A brief review of previous studies reveals a high prevalence of the use of psychotropes among the general population...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000118618
更新日期:1989-01-01 00:00:00
abstract::Urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) levels in 53 depressed women were compared to current suicidal thoughts or activity. Comparisons were also made between MHPG and past suicide attempts, number of past attempts, and seriousness of the worst attempt. There was a weak trend for current but not past suicidali...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119072
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:Olfactory processing depends on dopamine metabolism and orbitofrontal cortex functioning, both known to be disturbed in attention-deficit/hyperactivity disorder (ADHD). Some investigations suggested alterations in olfactory processing (identification and sensitivity) in childhood and adult ADHD. METHODS:In t...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000323448
更新日期:2011-01-01 00:00:00
abstract::Cephalosporins may induce nonconvulsive status epilepticus (NCSE), a potentially reversible condition. Despite the wide use of these antibiotics, there are only few reported cases, because this condition is probably underestimated. We report two new cases of NCSE occurring during treatment with cefepime and ceftazidim...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000077370
更新日期:2004-01-01 00:00:00
abstract::Serotonergic dysfunction is implicated in Alzheimer's disease (AD) on the basis of studies of serotonin and its metabolite in postmortem specimens and CSF. There were also reports on association of a tryptophan hydroxylase (TPH) intron 7 variant and CSF 5-hydroxyindoleacetic acid concentrations. These suggested TPH mi...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000054856
更新日期:2001-01-01 00:00:00
abstract::Time trends and periodic cycles in REM sleep eye movements were examined in 6 functional and 6 mongoloid adolescent retardates. Both groups of subjects showed approximately equal percentages of linear trends, quadratic trends, linear and quadratic trends, and absence of trend. The eye movement time-series were subject...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117524
更新日期:1976-01-01 00:00:00
abstract::During the last few years, the working group 'Psychophysiology' of the Association for Methodology and Documentation in Psychiatry (AMDP) discussed the possibility of the establishment of defined EEG modules in psychiatry. It was the aim to create a common data pool in order to be able to have access to larger data se...
journal_title:Neuropsychobiology
pub_type: 指南,杂志文章
doi:10.1159/000119370
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:Executive functions (EF) are often impaired in autism spectrum disorder (ASD). Such dysfunctions are associated with anxiety, depression, and a lack of autonomy. Transcranial direct current stimulation (tDCS) has been shown to enhance EF in healthy adults and clinical populations and to improve working memor...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000501025
更新日期:2019-01-01 00:00:00
abstract::Disturbances in the serotonergic neurotransmission system have been implicated in the etiology of attention deficit/hyperactivity disorder (ADHD). As the importance of genetic factors is well established, genes encoding for proteins of the serotonergic pathway are important candidates to unravel the underlying genetic...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000068870
更新日期:2003-01-01 00:00:00
abstract::Six WHO Collaborating Centre took part in the study of the antithymic activity of blood sera of patients suffering from schizophrenia. Blood serum specimens from 118 schizophrenic patients and 62 mentally healthy donors were investigated. Statistically significant differences between schizophrenic patients and the con...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117781
更新日期:1980-01-01 00:00:00