Association study of a functional MAOA-uVNTR gene polymorphism and cognitive function in healthy females.

Abstract:

:Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine and these neurotransmitters are hypothesized to be involved in the cognitive function of humans. This study of a cohort of 191 healthy young Chinese females attempts to utilize the intelligence quotient (IQ), Wisconsin Card Sorting Test (WCST) and P300 event-related potentials as cognitive assessments for testing the relationship between the polymorphism with a variable number of tandem repeats (VNTR) in the upstream regulatory region (MAOA-uVNTR) and cognition. The results demonstrate that subjects bearing the 4/4-repeat genotype have a significantly higher full IQ than subjects bearing the 3/3-repeat genotype. However, there is no significant association between this MAOA-uVNTR polymorphism and the WCST and P300. Our study shows that the MAOA-uVNTR genetic polymorphism plays a role in the IQ; however, this may be a chance finding as the result was negative after using the Bonferroni adjustment. Therefore, we suggest that our study should be replicated and that the testing method, sex, disease and ethnicity should also be considered in future studies.

journal_name

Neuropsychobiology

journal_title

Neuropsychobiology

authors

Yu YW,Tsai SJ,Hong CJ,Chen MC,Yang CW,Chen TJ

doi

10.1159/000086609

keywords:

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

77-82

issue

2

eissn

0302-282X

issn

1423-0224

pii

86609

journal_volume

52

pub_type

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