Abstract:
:Monoamine oxidase A (MAOA) is a mitochondrial enzyme involved in the degradation of dopamine, serotonin and norepinephrine and these neurotransmitters are hypothesized to be involved in the cognitive function of humans. This study of a cohort of 191 healthy young Chinese females attempts to utilize the intelligence quotient (IQ), Wisconsin Card Sorting Test (WCST) and P300 event-related potentials as cognitive assessments for testing the relationship between the polymorphism with a variable number of tandem repeats (VNTR) in the upstream regulatory region (MAOA-uVNTR) and cognition. The results demonstrate that subjects bearing the 4/4-repeat genotype have a significantly higher full IQ than subjects bearing the 3/3-repeat genotype. However, there is no significant association between this MAOA-uVNTR polymorphism and the WCST and P300. Our study shows that the MAOA-uVNTR genetic polymorphism plays a role in the IQ; however, this may be a chance finding as the result was negative after using the Bonferroni adjustment. Therefore, we suggest that our study should be replicated and that the testing method, sex, disease and ethnicity should also be considered in future studies.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Yu YW,Tsai SJ,Hong CJ,Chen MC,Yang CW,Chen TJdoi
10.1159/000086609keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
77-82issue
2eissn
0302-282Xissn
1423-0224pii
86609journal_volume
52pub_type
杂志文章abstract::The responses of cortisol to acute administration of saline and of clonidine (2.5 micrograms/kg B.W.) were examined in 10 children and adolescents with major depressive disorder and in 10 age- and sex-matched controls. Clonidine administration did not inhibit cortisol secretion in controls or in patients, contrary to ...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
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journal_title:Neuropsychobiology
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doi:10.1159/000118384
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journal_title:Neuropsychobiology
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doi:10.1159/000117524
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doi:10.1159/000337739
更新日期:2012-01-01 00:00:00
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doi:10.1159/000118982
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journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1996-01-01 00:00:00
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journal_title:Neuropsychobiology
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pub_type: 临床试验,杂志文章
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更新日期:1994-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000118112
更新日期:1984-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000488157
更新日期:2017-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章,随机对照试验
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更新日期:2012-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000182889
更新日期:2008-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000138916
更新日期:2008-01-01 00:00:00
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doi:10.1159/000446918
更新日期:2016-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117533
更新日期:1976-01-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000076723
更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
doi:10.1159/000118303
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pub_type: 杂志文章
doi:10.1159/000106476
更新日期:2007-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118813
更新日期:1992-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1159/000075338
更新日期:2004-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117616
更新日期:1978-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 指南,杂志文章
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更新日期:1997-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
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更新日期:2000-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1999-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
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更新日期:1983-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-01-01 00:00:00