Abstract:
:The systematic recording of spontaneous electrodermal activity (EDA) on 23 normal subjects during 5 15-min sessions and the self-rating of anxious and/or depressive moods (Q-sort forced choice) shows a positive linear relationship between spontaneous EDA and anxious mood despite a low covariation between those two variables. The same relationship is found with a lower degree of confidence in depression. A greater EDA is observed in the rare pattern of "depression higher than anxiety', than in the opposite case. The discussion of the results deals with the parallelism between a physiological continuum and affective states.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
de Bonis M,Baqué EFdoi
10.1159/000117616subject
Has Abstractpub_date
1978-01-01 00:00:00pages
15-25issue
1eissn
0302-282Xissn
1423-0224journal_volume
4pub_type
杂志文章abstract::This study investigated the acute effect of a dose range of low-to-moderate binge-like methamphetamine treatments on the regional expression of neurotrophin proteins in the brain and serum 2 h after the last dose, in addition to assessing the behavioural effects and dopamine neurotransmitter changes produced. Male Spr...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000480513
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:Disgust is a basic emotion that involves feelings of revulsion and withdrawal behavior from dangerous/infectious situations. Very little is known about the genetic basis of disgust sensitivity. The dopamine receptor D4 (DRD4) and catechol-O-methyltransferase (COMT) genes have been implicated in neuroticism-r...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000275822
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Lithium augmentation is a first-line strategy for depressed patients resistant to antidepressive therapy, but little is known about patients' subsequent long-term course or outcome predictors. We investigated long-term outcomes of unipolar depressed patients who had participated in a study on the effects of ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000234814
更新日期:2009-01-01 00:00:00
abstract::Recent findings indicate that the memory-impairing effects of benzodiazepines may preferentially involve the basolateral nucleus of the amygdala. To test this hypothesis we examined the effects on pretrial injection of diazepam into the central as compared to the lateral/basolateral amygdaloid nuclei on memory for a c...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119209
更新日期:1995-01-01 00:00:00
abstract::Spontaneous and drug-induced locomotor behavior was investigated in rats subjected to lesions of the ventral striatum, using the neurotoxin 6-hydroxydopamine to produce selective depletions of dopamine. Locomotor activity changed with time after lesion. At 2 weeks postoperative less spontaneous rearings were observed ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118311
更新日期:1986-01-01 00:00:00
abstract::Angiotensin-converting enzyme (ACE) is a key enzyme in the renin-angiotensin system and can modulate dopamine turnover in the midbrain. Previous studies have revealed changes in the central ACE levels for schizophrenic patients, possibly related to the polydipsia commonly demonstrated for chronic schizophrenia. An ins...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000054911
更新日期:2001-01-01 00:00:00
abstract::Volunteers who develop a cold following virus challenge were significantly slower on choice reaction time tasks than those with no illness. This effect was still observed after the clinical symptoms had gone. In contrast to this, influenza illnesses only impaired performance in tasks in which subjects were uncertain w...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118558
更新日期:1989-01-01 00:00:00
abstract::Piracetam, when applied microiontophoretically and/or by hydropneumatic pump on the somatosensory cortex and hippocampus of the rat, affected neuronal activity by depressing or facilitating the spontaneous firing rate, depending on the area studied. Its effect were either additive or counteracting the actions of gluta...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118449
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:Olfactory processing depends on dopamine metabolism and orbitofrontal cortex functioning, both known to be disturbed in attention-deficit/hyperactivity disorder (ADHD). Some investigations suggested alterations in olfactory processing (identification and sensitivity) in childhood and adult ADHD. METHODS:In t...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000323448
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Depressive disorder (DD) is characterized by an inflammatory process and oxidative stress. Cyclooxygenase-2 (COX-2), the expression of which increases in depression, is an enzyme involved in inflammation and free radical processes. The aim of our study was to assess the correlation between single nucleotide ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000317284
更新日期:2010-01-01 00:00:00
abstract::Urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) levels in 53 depressed women were compared to current suicidal thoughts or activity. Comparisons were also made between MHPG and past suicide attempts, number of past attempts, and seriousness of the worst attempt. There was a weak trend for current but not past suicidali...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119072
更新日期:1994-01-01 00:00:00
abstract::The responses of cortisol to acute administration of saline and of clonidine (2.5 micrograms/kg B.W.) were examined in 10 children and adolescents with major depressive disorder and in 10 age- and sex-matched controls. Clonidine administration did not inhibit cortisol secretion in controls or in patients, contrary to ...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000119022
更新日期:1993-01-01 00:00:00
abstract::Clozapine is an effective atypical antipsychotic that has high affinity for many neurotransmitter receptors. Among the adverse effects of clozapine, urinary incontinence is commonly found and is suggested to be caused by alpha-adrenergic blockade. We tested the hypothesis that clozapine-induced urinary incontinence is...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000026674
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:The present study investigated the effects of rapid tryptophan depletion (RTD), and the ensuing reduction of central nervous system levels of serotonin (5-HT), upon reactive aggression in patients with attention deficit/hyperactivity disorder (ADHD). Furthermore, it was asked whether the relation between 5-H...
journal_title:Neuropsychobiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000112951
更新日期:2007-01-01 00:00:00
abstract::There is evidence that serotonin and norepinephrine are in some way involved in the pathophysiology of anxiety disorders. Urinary levels of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) and the norepinephrine metabolite vanillylmandelic acid (VMA) were measured in 46 patients with generalized anxiety di...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119165
更新日期:1995-01-01 00:00:00
abstract::Prolactin (PRL) and growth hormone (GH) response to L-Dopa have been studied in 51 affectively ill women (26 unipolar and 25 bipolar) before and after amitriptyline treatment and in 14 normal female controls. There was no difference in GH response to L-dopa in all groups studied except for bipolar postmenopausal women...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117947
更新日期:1983-01-01 00:00:00
abstract::The region coding human leukocyte antigen (HLA) on chromosome 6q21 was shown to be associated with both the vulnerability to schizophrenia and presence of eye movement disturbances (EMD). The aim of this preliminary study was to investigate how individual class I and II HLA antigens in schizophrenic patients may be re...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000085595
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND AND AIMS:Time of onset of antipsychotic action is still a debated matter. We aimed to replicate and extend previous findings that early response can predict subsequent non-response. METHODS:86 acutely psychotic patients treated with haloperidol were studied. RESULTS:A PANSS reduction ≤16% at 1 week predict...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000337739
更新日期:2012-01-01 00:00:00
abstract::Evidence from preclinical studies, preliminary clinical reports, pharmacologic challenge studies and a small number of controlled trials suggests that several antiepileptic agents--valproate, carbamazepine, and clonazepam--may have therapeutic effects in the treatment of patients with panic disorder. We review the the...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000118971
更新日期:1993-01-01 00:00:00
abstract::Twenty-two female patients with anorexia nervosa, restricted type, 14-35 years old, were treated with a 4-month course of combined cognitive-behavioral therapy, nutritional counselling and antidepressant drugs (nortriptyline for 7, fluoxetine for 15). Patients were monitored for body mass index (BMI), for eating disor...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000119213
更新日期:1995-01-01 00:00:00
abstract::A potential candidate gene that could contribute to the education process is the apolipoprotein E (apo E) gene that has been shown to correlate with memory function and memory decline. We measured apo E polymorphism in groups of probands with different levels of education selected from a population sample. In the grou...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000054890
更新日期:2001-01-01 00:00:00
abstract::Tetrahydrobiopterin (BH(4)) is a vital cofactor maintaining availability of the amine neurotransmitters [dopamine (DA), noradrenaline (NA), and serotonin (5-HT)], regulating the synthesis of nitric oxide (NO) by nitric oxide synthase (NOS), and stimulating and modulating the glutamatergic system (directly and indirect...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000089002
更新日期:2005-01-01 00:00:00
abstract::Cardiovascular measurements were used as indicators of autonomic arousal during an orthostatic challenge test without medication and after a test dose of 150 mg perazine in 20 acute schizophrenic patients. Unmedicated schizophrenics showed elevated heart rates and elevated systolic and diastolic blood pressure in comp...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000119144
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND:Limbic circuitry, especially the anterior cingulate gyrus, has been implicated in the pathophysiology and cognitive changes of schizophrenia. Previous diffusion tensor imaging studies have demonstrated that the integrity of the anterior cingulum (AC) is abnormal in schizophrenia. However, the relationship be...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000355296
更新日期:2013-01-01 00:00:00
abstract::Eight patients with chronic obsessive-compulsive neurosis were subjected to trazodone, an antidepressant acting on the serotonergic system. After 4 weeks of treatment, 6 showed significant reduction in the obsessional symptoms which was sustained after a 6-week follow-up. The 2 patients who did not show improvement ha...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118274
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Psychosis spectrum disorders, especially schizophrenia, have been linked to disturbed dopaminergic activity in the brain. Plasma homovanillic acid (pHVA) levels partly represent dopaminergic metabolism in the central nervous system. In the present study associations between (changes in) pHVA levels, symptom ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000431095
更新日期:2015-01-01 00:00:00
abstract::The International Pharmaco-EEG Society (IPEG) presents updated guidelines summarising the requirements for the recording and computerised evaluation of pharmaco-EEG data in man. Since the publication of the first pharmaco-EEG guidelines in 1982, technical and data processing methods have advanced steadily, thus enhanc...
journal_title:Neuropsychobiology
pub_type: 指南,杂志文章,评审
doi:10.1159/000343478
更新日期:2012-01-01 00:00:00
abstract::The phenotype frequencies of HL-A specificities have been investigated in 47 chronic schizophrenics subdivided in an older and a younger group. The frequency of HL-A 9 was significantly increased in the psychotics as compared to a reference group of 1,263 healthy blood donors, pregnant women and potential kidney donor...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117496
更新日期:1975-01-01 00:00:00
abstract::The soporific effect of the neuroactive steroid pregnanolone, a metabolite of progesterone, and its relationship with plasma concentrations was assessed in 18 young, healthy, male volunteers for 2 h after administration of a single dose of pregnanolone prepared in two different formulations. Sedation was measured as s...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000119300
更新日期:1996-01-01 00:00:00
abstract::Memory loss and severe cognitive deficits in Alzheimer patients are supposed to be related to a reduction of acetylcholine as well as to central nervous deactivation. For the investigation of cholinergic deficits and deactivation, we used computer-assisted pupillometry. Cholinergic deficits caused by a particularly se...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026595
更新日期:1999-01-01 00:00:00