Abstract:
:The region coding human leukocyte antigen (HLA) on chromosome 6q21 was shown to be associated with both the vulnerability to schizophrenia and presence of eye movement disturbances (EMD). The aim of this preliminary study was to investigate how individual class I and II HLA antigens in schizophrenic patients may be related to schizophrenia and to the intensity of two kinds of EMD: fixation and smooth pursuit. The incidence of HLA antigens was compared between 40 schizophrenic patients (17 male, 23 female) and 198 healthy control subjects (112 male, 86 female). In schizophrenic patients, the intensity of EMD assessed by infrared reflectometry and quantified on a scale from 0 to 3 was correlated with the incidence of HLA antigens. A number of differences regarding HLA antigens were found between schizophrenic patients and healthy subjects. Significant correlation was also obtained between some EMD and a number of HLA antigens. Antigens A24 and A28 were found to occur in different frequencies in schizophrenic patients and healthy control subjects. They also correlated with EMD on the fixation and smooth pursuit tests. The results obtained show an association between HLA antigens and EMD as an endophenotypic marker of schizophrenia, and may add to other findings on susceptibility loci for schizophrenia on chromosome 6p21. A limitation of this study is a small number of investigated patients with schizophrenia.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Bogacki PA,Borkowska A,Wojtanowska-Bogacka M,Rybakowski JKdoi
10.1159/000085595keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
204-10issue
4eissn
0302-282Xissn
1423-0224pii
85595journal_volume
51pub_type
杂志文章abstract:BACKGROUND:Eugen Bleuler, in his book Dementia praecox oder Gruppe der Schizophrenien, discussed issues of social psychiatry, and he considered complex interventions pivotal in the care for people with schizophrenia. Bleuler emphasised the potential of therapeutic communities in providing care, the drawbacks of extende...
journal_title:Neuropsychobiology
pub_type: 历史文章,杂志文章,评审
doi:10.1159/000338549
更新日期:2012-01-01 00:00:00
abstract::The new anticonvulsant, lamotrigine, is becoming an important tool in the treatment of bipolar disorder, including bipolar depression. Its efficacy in bipolar depression might be linked to its inhibition of serotonin uptake. We present the case of a female schizoaffective patient successfully treated with 400 mg of la...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026538
更新日期:1998-10-01 00:00:00
abstract::The phenotype frequencies of HL-A specificities have been investigated in 47 chronic schizophrenics subdivided in an older and a younger group. The frequency of HL-A 9 was significantly increased in the psychotics as compared to a reference group of 1,263 healthy blood donors, pregnant women and potential kidney donor...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117496
更新日期:1975-01-01 00:00:00
abstract::Fifteen general practitioners treated 21 newly diagnosed insomniac patients with benzodiazepines. In 15 cases, a short-acting benzodiazepine was prescribed without regard to the type, severity, duration and probable cause of insomnia. Sleep-wake ambulatory recordings were made at the respective homes of the patients b...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119461
更新日期:1990-01-01 00:00:00
abstract::REM sleep behavior disorder (RBD) is so far a possibly underestimated yet well-described sleep disorder. Its major impact is the vigorous sleep behavior that often results in injuries to the patient himself or to people sleeping nearby. We treated a 64-year-old male with a clinically and polysomnographically confirmed...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000119383
更新日期:1997-01-01 00:00:00
abstract::The effects of the addition of short-term lithium to long-term administration of antidepressants (clomipramine or citalopram) on the levels of 5-HT and 5-HIAA and serotonergic receptors were studied in the rat cortex. The addition of short-term Li to long-term antidepressant treatment potentiated an increase in 5-HIAA...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119243
更新日期:1996-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118460
更新日期:1988-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000366488
更新日期:2014-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000118075
更新日期:1984-01-01 00:00:00
abstract::The prevalence of an abnormal response to the 1 mg dexamethasone suppression test (DST) was examined in 40 inpatients suffering from a major depressive disorder (MDD), 17 inpatients suffering from schizophrenia, and 30 normal controls. 23.5% of the schizophrenics were DST nonsuppressors compared to 52.5% of MDD patien...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118252
更新日期:1986-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000480513
更新日期:2017-01-01 00:00:00
abstract::This study aimed to investigate the binding affinity of [3H]GABA and [3H]beta-alanine to GABA transporters GAT-1 and GAT-3 in the human dorsolateral prefrontal cortex (Brodmanns' area 9) in schizophrenia. Using post mortem tissue from individuals diagnosed with schizophrenia (n=6) and control subjects (n=6), the densi...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000079975
更新日期:2004-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118824
更新日期:1992-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118093
更新日期:1984-01-01 00:00:00
abstract::The concentrations of adenosine 3'5'-cyclic monophosphate (cyclic AMP) in cerebrospinal fluid (CSF) in manic-melancholic patients were studied. As control groups served patients suffering from other psychiatric disorders as well as neruological and orthopedic patients. The results showed no difference between the vari...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117548
更新日期:1976-01-01 00:00:00
abstract:INTRODUCTION:Butyrate is a short-chain fatty acid metabolite produced by microbiota in the colon. With its antioxidant properties, butyrate has also been shown to alter the neurological functions in affective disorder models, suggesting it as a key mediator in gut-brain interactions. OBJECTIVE:Here, we evaluated the n...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000510886
更新日期:2020-10-19 00:00:00
abstract::It has been 60 years since Cade first described patients who responded to antimanic lithium treatment. Two decades later, responders to lithium stabilization emerged in larger numbers. The responses of many severely ill bipolar patients to lithium were striking and called for an explanation. Remarkable reactions to a ...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000314305
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:Stress is a precipitating factor for both binge eating and bulimia nervosa (BN); however, the biological mechanisms through which it may trigger binge eating are poorly understood. There is evidence that the adrenal hormone cortisol and the gastric peptide ghrelin might be involved in stress-induced food ing...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000341877
更新日期:2012-01-01 00:00:00
abstract::All-night sleep of 5 healthy male subjects was scored on the basis of EEG (paper records), EMG and EOG into the stages of wakefulness, REM sleep and slow sleep stages 1-4 according to Rechtschaffen and Kales. Spectral analysis for 8 EEG channels was then performed and spectral parameters (total power and coherence for...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118067
更新日期:1984-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000048671
更新日期:2002-01-01 00:00:00
abstract::93 cases of reactive depression have been followed up in order to investigate the long-term course of illness. By independent classification of reactive and endogenous depressions the authors agreed on diagnosis for 94%. Ten subgroups of reactive depressions are illustrated by case histories. It is of practical import...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117739
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND/AIMS:In general, humans tend to discount the value of delayed reward. An increase in the rate of discounting leads to an inability to select a delayed reward over a smaller immediate reward (reward-delay impulsivity). Although deficits in the serotonergic system are implicated in this reward-delay impulsivit...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000328990
更新日期:2012-01-01 00:00:00
abstract::Platelet 5-HT and plasma cortisol concentrations were determined in 59 schizophrenic patients with different time course of illness before and after dexamethasone suppression test (DST). An abnormal DST (nonsuppression) was observed in 51% of patients. In these patients basal cortisol and platelet 5-HT concentrations ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026493
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:In alcohol and other substance dependencies, patients often suffer relapse despite better knowledge and their intention to remain abstinent. A variety of neurotransmitter systems and their respective alterations due to the chronic drug intake are involved in mechanisms that facilitate relapse. It has been po...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000362838
更新日期:2014-01-01 00:00:00
abstract::Memory loss and severe cognitive deficits in Alzheimer patients are supposed to be related to a reduction of acetylcholine as well as to central nervous deactivation. For the investigation of cholinergic deficits and deactivation, we used computer-assisted pupillometry. Cholinergic deficits caused by a particularly se...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026595
更新日期:1999-01-01 00:00:00
abstract::Six WHO Collaborating Centre took part in the study of the antithymic activity of blood sera of patients suffering from schizophrenia. Blood serum specimens from 118 schizophrenic patients and 62 mentally healthy donors were investigated. Statistically significant differences between schizophrenic patients and the con...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117781
更新日期:1980-01-01 00:00:00
abstract::Possible age effects on binding of [(3)H]lysergic acid diethylamide ([(3)H]LSD) to serotonin 5-HT(2A) receptors and of [(3)H]paroxetine to serotonin uptake sites were studied in platelets from healthy children (11-12 years of age), adolescents (16-17 years of age) and adults. Significant overall age effects were found...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026617
更新日期:1999-11-01 00:00:00
abstract::The responses of cortisol to acute administration of saline and of clonidine (2.5 micrograms/kg B.W.) were examined in 10 children and adolescents with major depressive disorder and in 10 age- and sex-matched controls. Clonidine administration did not inhibit cortisol secretion in controls or in patients, contrary to ...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000119022
更新日期:1993-01-01 00:00:00
abstract::Twenty-three chronic undifferentiated schizophrenics, 13 women and 10 men, aged 37-64 years with 15-to 40-year histories of the disease were given either thyrotropin-releasing hormone (TRH) (10 subjects) or DDAVP (13 subjects) with the aim to improve the negative symptoms of the disease and memory. TRH (600 micrograms...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118253
更新日期:1986-01-01 00:00:00
abstract::We hypothesized that levels of N-acetyl-beta-glucosaminidase (NAG) would differ between patients making serious versus nonserious suicide attempts. The levels of NAG from 11 patients hospitalized for serious suicide attempts were compared to 5 patients whose suicide attempts were not rated serious. There was a signifi...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000026688
更新日期:2000-01-01 00:00:00