Kindling with the beta-carboline FG7142 suggests separation between changes in seizure threshold and anxiety-related behaviour.

Abstract:

:The aim of this paper was to determine whether the prolonged decrease in seizure threshold produced by chemical kindling was accompanied by behavioural changes in tests of anxiety and aggression. The responses of rats in five tests were examined after chronic treatment with the benzodiazepine inverse agonist FG7142. This treatment caused chemical kindling, so that the originally proconvulsant drug caused full seizures. This effect is very long-lasting, and our previous work with mice had suggested that it might be accompanied by an increase in anxiety-related behavior. In the present work no significant differences were found between the behaviour of FG7142-kindled rats and vehicle-treated controls in social interaction test, elevated plus maze, or the Vogel conflict test of anxiety or in tests of home cage aggression or startle responses. The results therefore show that prolonged changes in seizure threshold can occur without alterations in the apparent level of anxiety.

journal_name

Neuropsychobiology

journal_title

Neuropsychobiology

authors

Taylor SC,Johnston AL,Wilks LJ,Nicholass JM,File SE,Little HJ

doi

10.1159/000118460

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

195-201

issue

4

eissn

0302-282X

issn

1423-0224

pii

118460

journal_volume

19

pub_type

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