Abstract:
:In a double-blind, placebo-controlled study the effect of nocturnal traffic noise and bedtime medication of a new benzodiazepine, OX-373, on objective and subjective sleep variables as well as on the quality of morning awakenings was investigated. 10 healthy subjects spent 17 nights in the sleep laboratory: 2 adaptation nights, 1 baseline night, 4 drug nights (20, 30, and 40 mg OX-373 and placebo) and 4 subsequent wash-out nights as well as 3 nights under traffic noise with placebo, 30 and 40 mg OX-373 and 3 subsequent wash-out nights. Nocturnal traffic noise with an intensity of 45-65 dB(A) induced sleep disturbances characterized by an increase in intermittent wakefulness and stage 1 and the number of nocturnal awakenings as well as by a decrease of spindle and REM sleep stages. Subjectively, a decrease of deep sleep and increase of light sleep and middle insomnia was reported. Upon awakening in the morning, mood was significantly deteriorated. The new benzodiazepine OX-373 attenuated the above-described traffic noise-induced changes and produced even oppositional alterations, such as a decrease in stage 1, number of awakenings and stage shifts while increasing stage 2. The drug alone decreased the number of awakenings and stage 1 and augmented stage 4 as compared with placebo, which was subjectively felt as an increase in deep sleep and as a decrease of light sleep, early and middle insomnia. In the morning, there were no signs of 'hangover', which was confirmed also by psychometry. Nor were there any clinically relevant alterations in blood pressure and pulse. Thus, our studies confirmed earlier pharmaco-EEG and psychometric investigations predicting OX-373 as well-tolerated anxiolytic sedative, and suggested further that traffic noise could eventually be utilized as an experimental provocative technique in order to induce a standardized sleep disturbance for early clinical drug evaluation of potentially hypnotic substances.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Saletu B,Grünberger Jdoi
10.1159/000117865subject
Has Abstractpub_date
1981-01-01 00:00:00pages
302-14issue
6eissn
0302-282Xissn
1423-0224journal_volume
7pub_type
临床试验,杂志文章abstract:BACKGROUND:We have investigated the efficacy of high-frequency left (HFL) versus low-frequency right (LFR) repetitive transcranial magnetic stimulation (rTMS) in depression, focusing on specific symptoms as possible predictors of outcome for these two different types of stimulation. METHOD:Seventy-four outpatients wit...
journal_title:Neuropsychobiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000315439
更新日期:2010-01-01 00:00:00
abstract::Little information exists on the concentrations of recent antidepressants and their metabolites in cerebrospinal fluid (CSF). Using a stereoselective method, we measured plasma and CSF levels of mirtazapine (MIR), N-demethylmirtazapine and 8-OH-MIR in 3 depressed patients treated with racemic MIR (45 mg/day) for 4 wee...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000098654
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Considerable evidence suggests that variation of the serotonin-transporter-linked promoter region (5- HTTLPR) is associated with anxiety-related traits. Academic outcomes are also more closely related to trait anxiety. This preliminary study aimed to explore the association between academic performance and l...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000317550
更新日期:2011-01-01 00:00:00
abstract::Fengabine is a new GABAmimetic compound active in animal models predictive of antidepressant activity. The present overview reports the results of 6 double-blind trials versus tricyclics (TCAs) (3 in outpatients and 3 in inpatients). Overall, 398 adult patients (149 males and 249 females) were treated; 194 with fengab...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000118485
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVES:eLORETA (exact low-resolution brain electromagnetic tomography) is a technique created by Pascual-Marqui et al. [Int J Psychophysiol. 1994 Oct; 18(1): 49-65] for the 3-dimensional representation of current source density in the brain by electroencephalography (EEG) data. Kurtosis analysis allows for the iden...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000495522
更新日期:2019-01-01 00:00:00
abstract::Changes of field potentials electrically evoked from the mesencephalon were studied in two dopaminergic target areas. The modulation of the responses in prefrontal cortex and striatum induced by intravenous injection of various compounds influencing central dopaminergic transmission is followed. In general, drugs with...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118200
更新日期:1985-01-01 00:00:00
abstract::Electrovestibulography (EVestG) recordings have been previously applied toward classifying and/or measuring the severity of several neurological disorders including depression with and without anxiety. This study's objectives were to: (1) extract EVestG features representing physiological differences of healthy women ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000487771
更新日期:2017-01-01 00:00:00
abstract::The relation between EEG spectral power and alterations of the visual evoked potential (VEP) during different behavioral states and after intraperitoneal application of neuroactive drugs have been investigated in Long-Evans rats. FFT power and field potential maps were made in five behavioral states of the unrestraine...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119178
更新日期:1995-01-01 00:00:00
abstract::Individuals differ in hypnotizability. Information on hypnotizability-related EEG characteristics is controversial and incomplete, particularly on intracerebral source localization and EEG dimensionality. 19-channel, eyes-closed resting EEGs from right-handed, healthy, 8 high- and 4 low-hynotizable subjects (age: 26.7...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000054942
更新日期:2001-01-01 00:00:00
abstract::The medical histories of 600 psychotic and 369 nonpsychotic subjects were examined for the occurrence of rheumatic chorea. There was significantly more rheumatic chorea in the histories of psychotic patients than in nonpsychotics (p less than 0.01, chi-square). Neuropathological associations are discussed. ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118234
更新日期:1986-01-01 00:00:00
abstract::Past epidemiological and clinical research has identified depression as the most common psychiatric disorder associated with headache. The present study carried out in a neurology headache clinic showed that the major associations were with current anxiety disorders, especially panic and related conditions. These find...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119182
更新日期:1995-01-01 00:00:00
abstract::The relation between fasting, a.m. plasma prolactin and plasma/homovanillic acid (HVA) was studied in 9 healthy males on one occasion and in 9 healthy females on two occasions (in the follicular and luteal phase of the menstrual cycle). There was a significant inverse correlation between plasma HVA and plasma prolacti...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118303
更新日期:1986-01-01 00:00:00
abstract::Using event-related potentials (ERPs), a reduction in the auditory N100, N200 and P300 amplitude has been found in schizophrenic patients and may represent some pathophysiological deficit. Therefore, we investigated whether the genetic variant of the serotonin-2A receptor is associated with ERP change after clozapine ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000054871
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND/AIMS:Neurotrophins such as brain-derived neurotrophic factor (BDNF) are vital for neuronal survival and adaptive plasticity. With high BDNF gene expression in the prefrontal cortex, BDNF is a potential regulatory factor for building and maintaining cognitive reserves. Recent studies suggest that individual d...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000362242
更新日期:2014-01-01 00:00:00
abstract::Apomorphine, a dopamine receptor agonist (given in a dose of 0.75 mg s.c.), was administered to 8 healthy volunteers; electroencephalograph (EEG) and event-related potential (ERP) mapping were performed before dosing and 0.5, 1.5 and 2.5 h after dosing. Apomorphine caused an overall increase in beta activity at time 0...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000026560
更新日期:1999-01-01 00:00:00
abstract::An association between negative symptoms and frontal cortex abnormalities has been suggested in schizophrenic patients. We tested whether this association can be found when patients' task performance is good and while controlling for possible cortical atrophy. We investigated regional cerebral blood flow with the xeno...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119262
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVE:C-reactive protein (CRP), a marker of underlying low-grade inflammation, has been associated with the pathophysiology of bipolar disorder. Additionally, bipolar disorder may be accompanied by functional or structural cerebral alterations. We attempted to discover whether serum high-sensitivity CRP (hs-CRP) le...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000353613
更新日期:2013-01-01 00:00:00
abstract::The effects of the addition of short-term lithium to long-term administration of antidepressants (clomipramine or citalopram) on the levels of 5-HT and 5-HIAA and serotonergic receptors were studied in the rat cortex. The addition of short-term Li to long-term antidepressant treatment potentiated an increase in 5-HIAA...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119243
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVE:A growing number of studies indicate increased impulsivity in patients with opioid dependence (OD). However, few studies exclude concomitant drug use and consider depression as a comorbidity, both of which can bias results. AIM:We aimed to compare impulsivity in patients with OD enrolled in maintenance thera...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000494697
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:Due to its pharmacological properties, opipramol may be useful in the context of evening premedication in anaesthesiology. This trial examines whether quality of sleep the night prior to surgery can be improved by opipramol and whether this effect is dose dependent. A second objective of this study is to exam...
journal_title:Neuropsychobiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000323799
更新日期:2011-01-01 00:00:00
abstract::Cephalosporins may induce nonconvulsive status epilepticus (NCSE), a potentially reversible condition. Despite the wide use of these antibiotics, there are only few reported cases, because this condition is probably underestimated. We report two new cases of NCSE occurring during treatment with cefepime and ceftazidim...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000077370
更新日期:2004-01-01 00:00:00
abstract::Spontaneous and drug-induced locomotor behavior was investigated in rats subjected to lesions of the ventral striatum, using the neurotoxin 6-hydroxydopamine to produce selective depletions of dopamine. Locomotor activity changed with time after lesion. At 2 weeks postoperative less spontaneous rearings were observed ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118311
更新日期:1986-01-01 00:00:00
abstract::Saliva cortisol was measured at 11 p.m. in a sample of 74 psychiatric inpatients composed of 24 primary endogenous depressives, 40 secondary depressives and 20 nondepressives (DSM III and Saint-Louis criteria). Primary depressives had significantly higher 11 p.m. saliva cortisol levels than nondepressives (p less than...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118384
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:The rs1344706 single nucleotide polymorphism in the ZNF804A gene is a common variant with strong evidence for association with schizophrenia. Recent studies show an association of rs1344706 with cognitive functioning, and there is some evidence suggesting that the risk allele may increase susceptibility for ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000339731
更新日期:2012-01-01 00:00:00
abstract::The formerly designed method for quantitative evaluation of drug effects in rats is employed for the classification of three different neuroleptic drugs, namely sulpiride, clozapine and haloperidol. Analysis of the power density spectra as obtained from the recorded activity in the cortex, striatum and reticular core ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118220
更新日期:1985-01-01 00:00:00
abstract::Suicide is a major problem for psychiatry. Depression is the most common mental disorder related to suicidal behavior. The present study aimed at investigating the relationship between the symptomatology related to death, dying, and suicide and neurobiological factors in depressed patients. Fifty patients aged 21-60 y...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000075338
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Rasagiline and selegiline are classified as monoamine oxidase B (MAO-B) inhibitors. The present investigation deals with time-dependent electrical frequency changes (electropharmacograms) induced by these, as well as by aminoindan, the major metabolite of rasagiline. METHOD:Adult rats (day-night converted, ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000319947
更新日期:2010-01-01 00:00:00
abstract::Schizophrenia is a heterogeneous and multidimensional disorder. The different syndromes or dimensions of this disorder represent distinct pathophysiological processes. Evidence is growing that each of the composite syndromes or dimensions of this disorder is associated with specific validators. This article reviewed n...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000119310
更新日期:1996-01-01 00:00:00
abstract::In the search for differential mechanisms underlying clozapine's superior antipsychotic efficacy, the purinergic system has been considered, since an antagonist of the adenosine receptor A(2A) was shown to block clozapine acute effects on c-fos expression in rat striatum. Further investigating the interaction of cloza...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000054925
更新日期:2001-01-01 00:00:00
abstract::A potential candidate gene that could contribute to the education process is the apolipoprotein E (apo E) gene that has been shown to correlate with memory function and memory decline. We measured apo E polymorphism in groups of probands with different levels of education selected from a population sample. In the grou...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000054890
更新日期:2001-01-01 00:00:00