Abstract:
:Plasma noradrenaline (NA), adrenaline (Ad), dopamine (DA), platelet serotonin (p5HT), free serotonin (f5HT), glucose, heart rate (HR) and blood pressure (BP) were measured before and after an oral load of glucose (OGTT) in 100 normal humans. One sham-feeding test was performed in every subject 2-3 weeks before OGTT. Aside from glucose rise, significant increases in NA, p5HT and the NA/Ad ratio were registered. No significant changes were observed in Ad, DA, f5HT, HR and BP mean +/- SE values. Significant reductions in the NA/p5HT, Ad/p5HT and DA/p5HT ratios' mean values were registered at 90 and 180 min. Several significant correlations were found amongst plasma neurotransmitters. Very high positive correlations were obtained when NA, Ad and DA were plotted against the ratio of each one of them over p5HT; however, they (r = 0.99) decreased significantly at 90 and 180 min. Upon evaluation of these results we infer that quiescence of adrenal glands occurs during OGTT. Under such circumstances, plasma neurotransmitters are left under the control of a central bipolar system: noradrenergic-parasympathetic. All numerical data strongly suggest that the noradrenergic system predominates at 60, 120 and 210 min, whereas parasympathetic predominance occurs at 90 and 180 min. The fact that the latter is interfered by atropine reinforces this hypothesis. Analyses of correlations also suggest that DA and p5HT probably act as a buffer and modulate the excessive increase in NA plasma levels registered during OGTT.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Lechin F,van der Dijs B,Lechin M,Báez S,Jara H,Lechin A,Orozco B,Rada I,Cabrera A,Jiménez Vdoi
10.1159/000118889keywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
4-11issue
1-2eissn
0302-282Xissn
1423-0224pii
118889journal_volume
26pub_type
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更新日期:2008-01-01 00:00:00
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pub_type: 临床试验,杂志文章
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journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
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journal_title:Neuropsychobiology
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doi:10.1159/000118914
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更新日期:2012-01-01 00:00:00
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doi:10.1159/000082852
更新日期:2005-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1983-01-01 00:00:00
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journal_title:Neuropsychobiology
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更新日期:1983-01-01 00:00:00
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更新日期:1997-01-01 00:00:00
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journal_title:Neuropsychobiology
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doi:10.1159/000118337
更新日期:1987-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1996-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000065412
更新日期:2002-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type:
doi:10.1159/000508679
更新日期:2020-07-20 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117773
更新日期:1980-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117609
更新日期:1977-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000234814
更新日期:2009-01-01 00:00:00