Conditional associative learning in drug-free schizophrenic patients.

Abstract:

:The performance on spatial and nonspatial associative learning tasks was tested in a sample of male drug-free DSM III-diagnosed schizophrenic patients and in a closely matched normal control group. Schizophrenics showed a worse performance on both versions of the task, but especially on the nonspatial one. A significant correlation was observed between some indices of the nonspatial task and the scores on two subscales (affective flattening and anhedonia) of the scale for the assessment of negative symptoms by Andreasen. These results are consistent with the hypothesis of a dysfunction of dorsolateral prefrontal cortex in schizophrenia and with the postulated linkage between such dysfunction and negative schizophrenic symptomatology.

journal_name

Neuropsychobiology

journal_title

Neuropsychobiology

authors

Kemali D,Maj M,Galderisi S,Monteleone P,Mucci A

doi

10.1159/000118337

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

30-4

issue

1-2

eissn

0302-282X

issn

1423-0224

pii

118337

journal_volume

17

pub_type

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