Abstract:
:All-night sleep of 5 healthy male subjects was scored on the basis of EEG (paper records), EMG and EOG into the stages of wakefulness, REM sleep and slow sleep stages 1-4 according to Rechtschaffen and Kales. Spectral analysis for 8 EEG channels was then performed and spectral parameters (total power and coherence for certain frequency bands) extracted. Stepwise linear discriminant analysis was applied to these spectral parameters to see how well the polygraphically defined sleep stages were recognized. While the results of each intrasubject analysis were satisfactory (error rates between 10 and 15%), a more detailed analysis revealed that most errors occur between nearby slow sleep stages or between S1 and REM or wakefulness. This is related to the fact that Rechtschaffen and Kales classify into discrete stages an essentially continuous process and this is, to some extent, arbitrary. This interpretation is supported by examples. Cross-classification of each subject on the basis of the remaining 4 increases the error rates drastically. A simple way of avoiding this effect, by standardizing the individual data, is shown to work nicely in this case.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Molinari L,Dumermuth G,Lange Bdoi
10.1159/000118067subject
Has Abstractpub_date
1984-01-01 00:00:00pages
140-8issue
2eissn
0302-282Xissn
1423-0224journal_volume
11pub_type
杂志文章abstract::Early N1P2 and late N2P3 responses generated in an auditory oddball paradigm are topographically compared in three psychiatric patient groups. In schizophrenia N1 and N2 amplitude is comparable with dementia and significantly decreased with respect to affective disorder. In contrast, P3 amplitude does not allow discri...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119343
更新日期:1997-01-01 00:00:00
abstract::Analysis of the mechanisms underlying the clinical effects of different drugs is a vital part of psychopharmacology. It is fair to say, however, that such analyses have thus far met with little success. This lack of success can be traced to a variety of sources that have flawed the analytical process itself. Detailed ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118131
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND:The availability of tobacco products is associated with the likelihood that adolescents will begin using tobacco. Yet the relationship between nicotine availability and voluntary consumption has not been tested experimentally in developing rats. METHOD:The impact of environmental availability on adolescent ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000103905
更新日期:2007-01-01 00:00:00
abstract::Acute quantitative electroencephalographic effects of cigarette smoking were examined in 15 smokers within a repeated-measures design which assessed changes in power-spectral estimates following acute pre-treatment with placebo, a dose (20 mg) of mecamylamine, a dose (0.6 mg) of scopolamine and a combined dose of meca...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026524
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:The present study investigated the effects of rapid tryptophan depletion (RTD), and the ensuing reduction of central nervous system levels of serotonin (5-HT), upon reactive aggression in patients with attention deficit/hyperactivity disorder (ADHD). Furthermore, it was asked whether the relation between 5-H...
journal_title:Neuropsychobiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000112951
更新日期:2007-01-01 00:00:00
abstract::In the present study, the effects of short-acting benzodiazepines on nocturnal sleep and the carryover effects of these drugs were studied. The study involved 10 young, healthy male subjects who had given their written informed consent to participate. Either a placebo (PLA), 0.125 mg triazolam (TRZ), 0.25 mg TRZ or 0....
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000070586
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:So-called Porteus mazes are used to investigate prefrontal cortex (PFC) functioning in normal subjects and patients with different neuropsychiatric disorders. Here we present data confirming the involvement of the PFC for the first time by means of functional magnetic resonance imaging (fMRI). To minimize mo...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000095742
更新日期:2006-01-01 00:00:00
abstract::This report presents the results of a retrospective analysis of pooled efficacy data from eight studies in which buspirone was compared to placebo in 520 patients with generalized anxiety disorder (GAD). In addition to evaluating overall efficacy in the composite patient data base, four criteria were used to identify ...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,meta分析,随机对照试验
doi:10.1159/000118837
更新日期:1992-01-01 00:00:00
abstract::A group of 27 patients with definite (n = 20) or probable (n = 7) RDC major depressive disorder underwent 2 sleep EEGs and 1 TRH test while in a drug-free depressive phase. A short mean REM latency (less than 60 min) identified 55.5% of major depressives while added use of blunted TSH responses (delta max. less than 5...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118350
更新日期:1987-01-01 00:00:00
abstract::Plasma levels of free and conjugated 3,4-dihydroxyphenylethyleneglycol (DOPEG), the main deaminated metabolite of norepinephrine, were assayed in 48 depressed patients before initiating a treatment with either maprotiline, an inhibitor of norepinephrine reuptake, or indalpine, a specific inhibitor of serotonin reuptak...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118243
更新日期:1986-01-01 00:00:00
abstract::Serum dopamine-beta-hydroxylase (DBH) levels were assessed in 150 depressed patients of both sexes, with a mean age of 44.0 +/- 12.3 (SD) years. Patients were divided into unipolars (n = 46), bipolars (n = 25), neurotic-reactive (n = 46) and unspecified (n = 38) i.e., those who did not fit into any of the previous cat...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117963
更新日期:1983-01-01 00:00:00
abstract::The prevalence of an abnormal response to the 1 mg dexamethasone suppression test (DST) was examined in 40 inpatients suffering from a major depressive disorder (MDD), 17 inpatients suffering from schizophrenia, and 30 normal controls. 23.5% of the schizophrenics were DST nonsuppressors compared to 52.5% of MDD patien...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118252
更新日期:1986-01-01 00:00:00
abstract::Quantitative pharmaco-EEG has become a useful technique for determining pharmacodynamic parameters after CNS-active drug administration. Nevertheless, one of the most important problems faced by practitioners of pharmaco-EEG is the difficulty in evaluating drug-specific effects. In this article, a methodology for comp...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119068
更新日期:1994-01-01 00:00:00
abstract::Six WHO Collaborating Centre took part in the study of the antithymic activity of blood sera of patients suffering from schizophrenia. Blood serum specimens from 118 schizophrenic patients and 62 mentally healthy donors were investigated. Statistically significant differences between schizophrenic patients and the con...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117781
更新日期:1980-01-01 00:00:00
abstract::Gamma oscillations (>30 Hz) in the brain are involved in attention, perception and memory. They are altered in various pathological states, as well as by neuropharmaceuticals, so that they are of interest in drug and clinical investigations. However, when the human electroencephalogram is recorded on the scalp, this n...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000382023
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVES:Corticotropin-releasing factor (CRF) plays a prominent role in mediating the effect of stressors on the hypothalamic-pituitary-adrenal axis. In this study, we examined the effects of chronic administration of second-generation antipsychotic drug ziprasidone on CRF mRNA expression in the hypothalamic paravent...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000322288
更新日期:2011-01-01 00:00:00
abstract::Supine and standing heart rate (HR) and blood pressure measures were compared among 19 nonsmoking normal controls, 29 smoking patients and 36 nonsmoking patients with panic disorder. The smoking patients had a significantly higher supine HR, standing diastolic blood pressure, standing mean blood pressure and supine an...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119440
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:The rs1344706 single nucleotide polymorphism in the ZNF804A gene is a common variant with strong evidence for association with schizophrenia. Recent studies show an association of rs1344706 with cognitive functioning, and there is some evidence suggesting that the risk allele may increase susceptibility for ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000339731
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Rasagiline and selegiline are classified as monoamine oxidase B (MAO-B) inhibitors. The present investigation deals with time-dependent electrical frequency changes (electropharmacograms) induced by these, as well as by aminoindan, the major metabolite of rasagiline. METHOD:Adult rats (day-night converted, ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000319947
更新日期:2010-01-01 00:00:00
abstract::Symptoms of anxiety suggest autonomic dysfunction and most of the psychotropic agents used to treat anxiety and affective disorders have strong autonomic effects. This article describes the utility and importance of analysis of heart rate and blood pressure time series to study cardiac autonomic function in psychiatri...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000119234
更新日期:1995-01-01 00:00:00
abstract::The serotonergic system has been implicated in the production of the N1 and P2 components of auditory evoked potentials (AEPs). Moreover, studies have indicated the influence of heritability in the genesis of these AEP components. The serotonin transporter is the major site of serotonin reuptake into the presynaptic n...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000065412
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:Olfactory processing depends on dopamine metabolism and orbitofrontal cortex functioning, both known to be disturbed in attention-deficit/hyperactivity disorder (ADHD). Some investigations suggested alterations in olfactory processing (identification and sensitivity) in childhood and adult ADHD. METHODS:In t...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000323448
更新日期:2011-01-01 00:00:00
abstract::The relationships between sensation seeking, curiosity about sex, and total and free testosterone in inmates were investigated. The role of other hormones such as luteinizing hormone (LH), follicle-stimulating hormone (FSH), and sex hormone-binding globulin (SHBG) in these relationships was also analyzed. Previous ana...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000082852
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Panic disorder (PD) is a common and often chronic psychiatric condition that can lead to considerable disability in daily life. Using [(18)F]fluorodeoxyglucose-PET, we examined brain baseline glucose metabolism in PD patients in comparison with normal controls and the changes in glucose metabolism after 12 w...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000337740
更新日期:2012-01-01 00:00:00
abstract::The formerly designed method for quantitative evaluation of drug effects in rats is employed for the classification of three different neuroleptic drugs, namely sulpiride, clozapine and haloperidol. Analysis of the power density spectra as obtained from the recorded activity in the cortex, striatum and reticular core ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118220
更新日期:1985-01-01 00:00:00
abstract::Several antipsychotics and antidepressants have been associated with electrocardiogram alterations, the most clinically relevant of which is the heart rate-corrected QT interval (QTc) prolongation, a risk factor for sudden cardiac death. Genetic variants influence drug-induced QTc prolongation and can provide valuable...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000493400
更新日期:2019-01-01 00:00:00
abstract::Spontaneous and drug-induced locomotor behavior was investigated in rats subjected to lesions of the ventral striatum, using the neurotoxin 6-hydroxydopamine to produce selective depletions of dopamine. Locomotor activity changed with time after lesion. At 2 weeks postoperative less spontaneous rearings were observed ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118311
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:A growing number of studies indicate increased impulsivity in patients with opioid dependence (OD). However, few studies exclude concomitant drug use and consider depression as a comorbidity, both of which can bias results. AIM:We aimed to compare impulsivity in patients with OD enrolled in maintenance thera...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000494697
更新日期:2019-01-01 00:00:00
abstract::The antidepressive and anxiolytic efficacy of flupenthixol has been investigated in numerous controlled and open trials involving patients with endogenous, reactive as well as senile depressions. When administered at a mean daily single or multiple dose of 1-2 mg, flupenthixol proved to be a very effective and well-to...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117999
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:Eugen Bleuler, in his book Dementia praecox oder Gruppe der Schizophrenien, discussed issues of social psychiatry, and he considered complex interventions pivotal in the care for people with schizophrenia. Bleuler emphasised the potential of therapeutic communities in providing care, the drawbacks of extende...
journal_title:Neuropsychobiology
pub_type: 历史文章,杂志文章,评审
doi:10.1159/000338549
更新日期:2012-01-01 00:00:00