GABA transporters GAT-1 and GAT-3 in the human dorsolateral prefrontal cortex in schizophrenia.

Abstract:

:This study aimed to investigate the binding affinity of [3H]GABA and [3H]beta-alanine to GABA transporters GAT-1 and GAT-3 in the human dorsolateral prefrontal cortex (Brodmanns' area 9) in schizophrenia. Using post mortem tissue from individuals diagnosed with schizophrenia (n=6) and control subjects (n=6), the density of GAT-1 was established by displacing [3H]GABA with muscimol, and for GAT-3 [3H]beta-alanine was used. Data analysis showed a significant decrease of GAT-1 levels (45%), and a significant increase of GAT-3 density (23%) within the dorsolateral prefrontal cortex of individuals diagnosed with schizophrenia when compared to age- and sex-matched controls. The observed decrease of GAT-1 could be explained as a consequence of the GABA hypo-function or the result of volumetric shrinkage of the cerebral cortex previously reported in this disease. The observed elevation of GAT-3 levels could be due to a compensatory effect for any functional loss of GABA re-uptake by the decreased GAT-1 levels.

journal_name

Neuropsychobiology

journal_title

Neuropsychobiology

authors

Schleimer SB,Hinton T,Dixon G,Johnston GA

doi

10.1159/000079975

keywords:

subject

Has Abstract

pub_date

2004-01-01 00:00:00

pages

226-30

issue

3

eissn

0302-282X

issn

1423-0224

pii

79975

journal_volume

50

pub_type

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