Differential Effects of Electroconvulsive Therapy in the Treatment of Major Depressive Disorder.

Abstract:

BACKGROUND/AIMS/METHODS:Electroconvulsive therapy (ECT) is still one of the most potent treatments in the acute phase of major depressive disorder (MDD) and particularly applied in patients considered treatment resistant. However, despite the frequent and widespread use of ECT for >70 years, the exact neurobiological mechanisms underlying its efficacy remain unclear. The present review aims to describe differential antidepressant and cognitive effects of ECT as well as effects on markers of neural activity and connectivity, neurochemistry, and inflammation that might underlie the treatment response and remission. RESULTS:Region- specific changes in brain function and volume along with changes in concentrations of neurotransmitters and neuroinflammatory cytokines might serve as potential biomarkers for ECT outcomes. CONCLUSIONS:However, as current data is not consistent, future longitudinal investigations should combine modalities such as MRI, MR spectroscopy, and peripheral physiological measures to gain a deeper insight into interconnected time- and modality-specific changes in response to ECT.

journal_name

Neuropsychobiology

journal_title

Neuropsychobiology

authors

Stippl A,Kirkgöze FN,Bajbouj M,Grimm S

doi

10.1159/000505553

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

408-416

issue

6

eissn

0302-282X

issn

1423-0224

pii

000505553

journal_volume

79

pub_type

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