Abstract:
BACKGROUND/AIMS/METHODS:Electroconvulsive therapy (ECT) is still one of the most potent treatments in the acute phase of major depressive disorder (MDD) and particularly applied in patients considered treatment resistant. However, despite the frequent and widespread use of ECT for >70 years, the exact neurobiological mechanisms underlying its efficacy remain unclear. The present review aims to describe differential antidepressant and cognitive effects of ECT as well as effects on markers of neural activity and connectivity, neurochemistry, and inflammation that might underlie the treatment response and remission. RESULTS:Region- specific changes in brain function and volume along with changes in concentrations of neurotransmitters and neuroinflammatory cytokines might serve as potential biomarkers for ECT outcomes. CONCLUSIONS:However, as current data is not consistent, future longitudinal investigations should combine modalities such as MRI, MR spectroscopy, and peripheral physiological measures to gain a deeper insight into interconnected time- and modality-specific changes in response to ECT.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Stippl A,Kirkgöze FN,Bajbouj M,Grimm Sdoi
10.1159/000505553subject
Has Abstractpub_date
2020-01-01 00:00:00pages
408-416issue
6eissn
0302-282Xissn
1423-0224pii
000505553journal_volume
79pub_type
杂志文章,评审abstract::Growth hormone (GH) possesses multiple metabolic effects, in particular with regard to glucose and lipid homeostasis. Studies on the effects of GH on body weight and food and water intake are scarce and have yielded controversial results. We investigated the effects of different modes of GH administration on the param...
journal_title:Neuropsychobiology
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journal_title:Neuropsychobiology
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pub_type: 临床试验,杂志文章,随机对照试验
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