Parameters of alteration of pentobarbital response by hypothalamic polypeptides.

Abstract:

:Both thyrotropin-releasing hormone (TRH) and amphetamine antagonize pentobarbital. They are more effective in the day than at night. This is true for TRH even when the dose of pentobarbital is increased at night to prolong sedation. Under this condition the day-night difference is lost for amphetamine. Both substances are more effective in cold ambient temperatures (18 degrees C) and less effective in warm temperatures, but their activity at warmer temperatures (37 degrees C) is still substantial. In contrast, somatotropin release-inhibiting factor (SRIF) augments the effects of pentobarbital at room temperature. This action is unaffected by time of day. However, the increase in sleeping time is lost in both a warm environment and in a cold environment.

journal_name

Neuropsychobiology

journal_title

Neuropsychobiology

authors

Prange AJ Jr,Breese GR,Jahnke GD,Cooper BR,Cott JM,Wilson IC,Lipton MA,Plotnikoff NP

doi

10.1159/000117484

subject

Has Abstract

pub_date

1975-01-01 00:00:00

pages

121-31

issue

2

eissn

0302-282X

issn

1423-0224

journal_volume

1

pub_type

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