Abstract:
:Both thyrotropin-releasing hormone (TRH) and amphetamine antagonize pentobarbital. They are more effective in the day than at night. This is true for TRH even when the dose of pentobarbital is increased at night to prolong sedation. Under this condition the day-night difference is lost for amphetamine. Both substances are more effective in cold ambient temperatures (18 degrees C) and less effective in warm temperatures, but their activity at warmer temperatures (37 degrees C) is still substantial. In contrast, somatotropin release-inhibiting factor (SRIF) augments the effects of pentobarbital at room temperature. This action is unaffected by time of day. However, the increase in sleeping time is lost in both a warm environment and in a cold environment.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Prange AJ Jr,Breese GR,Jahnke GD,Cooper BR,Cott JM,Wilson IC,Lipton MA,Plotnikoff NPdoi
10.1159/000117484subject
Has Abstractpub_date
1975-01-01 00:00:00pages
121-31issue
2eissn
0302-282Xissn
1423-0224journal_volume
1pub_type
杂志文章abstract::During interictal periods in 9 patients with partial epilepsy we examined whether there were correlations between the relative power of background EEG (power spectral analysis) and the absolute values of regional cerebral blood flow (rCBF) measured by 99mTc hexamethylpropylene amine oxime (HMPAO) SPECT in each cerebra...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119135
更新日期:1994-01-01 00:00:00
abstract:OBJECTIVE:Patients with bulimia nervosa (BN) are reported to have decreased postprandial levels of cholecystokinin (CCK) and peptide YY (PYY). Fatty nutrients are the most powerful stimulus for releasing these peptides. Cholestyramine is an anion exchanger which adsorbs bile salts and reduces the digestion of lipids, a...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000368160
更新日期:2014-01-01 00:00:00
abstract::In the present study all available young social alcohol abusers in the capital of Iceland are compared with a control group matched for age and intellectual level. Certain behaviour and social characteristics were found to occur more often during childhood among the abusers. Boys showing these characteristics should b...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117483
更新日期:1975-01-01 00:00:00
abstract:OBJECTIVE:There is some evidence that repetitive transcranial magnetic stimulation (rTMS) is an effective method of treating patients suffering from obsessive-compulsive disorder (OCD). Here, we tested the hypothesis that rTMS has a positive impact both on symptom severity and cognitive performance in such patients. Sp...
journal_title:Neuropsychobiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000446287
更新日期:2016-01-01 00:00:00
abstract::Disturbances in the serotonergic neurotransmission system have been implicated in the etiology of attention deficit/hyperactivity disorder (ADHD). As the importance of genetic factors is well established, genes encoding for proteins of the serotonergic pathway are important candidates to unravel the underlying genetic...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000068870
更新日期:2003-01-01 00:00:00
abstract::Angiotensin-converting enzyme (ACE) is a key enzyme in the renin-angiotensin system and can modulate dopamine turnover in the midbrain. Previous studies have revealed changes in the central ACE levels for schizophrenic patients, possibly related to the polydipsia commonly demonstrated for chronic schizophrenia. An ins...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000054911
更新日期:2001-01-01 00:00:00
abstract::In this study, we examined the effect of the 5-HT2A,C receptor agonist (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on locomotor activity and the head twitch response in rats by the repeated (twice daily for 4 days) subcutaneous administration of 0.9% saline (1 ml/kg) or (+/-)-3,4-Methylenedioxymethamphet...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026474
更新日期:1998-01-01 00:00:00
abstract::Failure to gain weight during withdrawal from chronic regimens of dependence-producing drugs is observed in laboratory rats. Withdrawal from the benzodiazepine anxiolytic agent diazepam, whether induced by cessation of treatment or precipitated by administration of the specific benzodiazepine antagonist Ro-15,1788, is...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118291
更新日期:1986-01-01 00:00:00
abstract:BACKGROUND:Patients with bipolar disorder are at a high risk for becoming obese. Adipokines are associated with depression and obesity via the inflammatory process. However, few studies have investigated the associations between depression and leptin, adiponectin and resistin levels in patients with bipolar disorder. W...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000366488
更新日期:2014-01-01 00:00:00
abstract::Twelve healthy male volunteers received pyritinol 600 or 1,200 mg or placebo for 3 days according to a randomised, double-blind crossover design. On the 1st and 3rd days of each of the three treatment periods subjects completed a battery of psychological tests including Critical Flicker Fusion (CFFT), Choice Reaction ...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000119478
更新日期:1990-01-01 00:00:00
abstract::As low-dose amphetamine stimulation of locomotor activity in the rat depends upon a mesolimbic dopaminergic substrate, neuroleptic antagonism of this behavior has been suggested as a model for studying antipsychotic activity. Animals in the present study received 21 days of chronic treatment with 1.0 mg/kg amphetamine...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118442
更新日期:1988-01-01 00:00:00
abstract::Cortisol has a modulatory influence on cognitive functions in humans. Both impairing and enhancing effects of cortisol administration have been shown for hippocampus-dependent declarative memory, and impairing effects have been shown for prefrontal-cortex-dependent working memory function. Given the high density of gl...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000262180
更新日期:2010-01-01 00:00:00
abstract::Hallucinogenic drug-induced states are considered as models for acute schizophrenic disorders (experimental psychoses). In a double-blind study with healthy volunteers we investigated the influence of the serotonergic hallucinogen psilocybin, the ecstasy-like drug 3,4-methylenedioxyethylamphetamine (MDE), the stimulan...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000063672
更新日期:2002-01-01 00:00:00
abstract::Growth hormone (GH) possesses multiple metabolic effects, in particular with regard to glucose and lipid homeostasis. Studies on the effects of GH on body weight and food and water intake are scarce and have yielded controversial results. We investigated the effects of different modes of GH administration on the param...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000048671
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:Schizophrenia, a common neurological disorder appearing in the late teens or early adulthood, is characterized by disorganized thinking, behaviour, and perception of emotions. Aberrant N-methyl-D-aspartate (NMDA) receptor-mediated synaptic plasticity is a major pathological event here due to dysfunction of do...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000454985
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Limbic circuitry, especially the anterior cingulate gyrus, has been implicated in the pathophysiology and cognitive changes of schizophrenia. Previous diffusion tensor imaging studies have demonstrated that the integrity of the anterior cingulum (AC) is abnormal in schizophrenia. However, the relationship be...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000355296
更新日期:2013-01-01 00:00:00
abstract::Eight healthy paid male volunteers (age: 21-28 years, mean: 24.5 +/- 1.7 years; weight 62-79 kg) were administered via intravenous infusion (3 min) acute 25-, 50-, and 75-mg doses of phosphatidylserine, or matching placebo in a latin-square design. Multichannel EEG recordings were performed in baseline conditions, dur...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000119041
更新日期:1990-01-01 00:00:00
abstract::We hypothesized that levels of N-acetyl-beta-glucosaminidase (NAG) would differ between patients making serious versus nonserious suicide attempts. The levels of NAG from 11 patients hospitalized for serious suicide attempts were compared to 5 patients whose suicide attempts were not rated serious. There was a signifi...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000026688
更新日期:2000-01-01 00:00:00
abstract::The acute effects of alcohol (0.7 g/kg) on visual signal detection performance and critical flicker fusion frequency (CFF) of normal volunteers were investigated using a signal detection theory analysis. When signal probability was low, alcohol affected the stimulus sensitivity and the reaction times of hits. Under a ...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000118209
更新日期:1985-01-01 00:00:00
abstract::The aim of this paper was to determine whether the prolonged decrease in seizure threshold produced by chemical kindling was accompanied by behavioural changes in tests of anxiety and aggression. The responses of rats in five tests were examined after chronic treatment with the benzodiazepine inverse agonist FG7142. T...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118460
更新日期:1988-01-01 00:00:00
abstract::The usual method for extracting evoked potentials from EEG, the so-called averaging, is based on the hypothesis of the stationarity of the single responses in every EEG segment. Therefore, the possible variability of the single responses cannot be regarded. In this paper, a method for estimating single evoked response...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118112
更新日期:1984-01-01 00:00:00
abstract::Plasma cortisol, catecholamine and cyclic AMP levels, response to dexamethasone suppression test and platelet MAO activity have been determined in 15 patients suffering from bipolar affective psychosis, each examined during a depressive, a manic and an euthymic phase, and in 15 sex- and age-matched normal controls. Me...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118071
更新日期:1984-01-01 00:00:00
abstract:BACKGROUND/AIMS:Previous functional neuroimaging studies have reported that patients with schizophrenia show reduced prefrontal activation during cognitive tasks whereas patients with schizotypal personality disorder (SPD) show preserved or even increased right prefrontal activation, compared to healthy controls; on th...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000129669
更新日期:2008-01-01 00:00:00
abstract:BACKGROUND:In depressed patients, overstimulation of the hypothalamo-pituitary-adrenocortical (HPA) system, probably caused by glucocorticoid receptor resistance, is the most consistent neurobiological finding. Glucocorticoids themselves are reported to increase leptin synthesis and secretion in humans. METHODS:We exa...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000103573
更新日期:2007-01-01 00:00:00
abstract::Isolation causes important changes in the behavioral reactivity of rats to environmental stimuli. These changes include deficit in sensorimotor gating and altered fear-like responses to aversive stimuli. Measures of ultrasound vocalizations at 20-22 kHz when rats are exposed to threatening conditions, such as novelty,...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000085820
更新日期:2005-01-01 00:00:00
abstract::In a double-blind, placebo-controlled study the effect of nocturnal traffic noise and bedtime medication of a new benzodiazepine, OX-373, on objective and subjective sleep variables as well as on the quality of morning awakenings was investigated. 10 healthy subjects spent 17 nights in the sleep laboratory: 2 adaptati...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000117865
更新日期:1981-01-01 00:00:00
abstract::The responses of cortisol to acute administration of saline and of clonidine (2.5 micrograms/kg B.W.) were examined in 10 children and adolescents with major depressive disorder and in 10 age- and sex-matched controls. Clonidine administration did not inhibit cortisol secretion in controls or in patients, contrary to ...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000119022
更新日期:1993-01-01 00:00:00
abstract::The effects of the addition of short-term lithium to long-term administration of antidepressants (clomipramine or citalopram) on the levels of 5-HT and 5-HIAA and serotonergic receptors were studied in the rat cortex. The addition of short-term Li to long-term antidepressant treatment potentiated an increase in 5-HIAA...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119243
更新日期:1996-01-01 00:00:00
abstract::In the Lundby Study, all mental illnesses, treated as well as untreated, that occurred during a 25-year period in a geographically defined Swedish general population sample were evaluated. All forms of psychiatric services used by the population during the same period were registered. The present study investigates th...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117990
更新日期:1983-01-01 00:00:00
abstract::The cerebrospinal fluid (CSF) concentrations of the monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) as well as their ratios and correlations were analyzed in relation to the season of birth. The sample consisted of 241 drug-free patients par...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026561
更新日期:1999-01-01 00:00:00