Abstract:
:An auditory event-related potential paradigm was designed to objectively quantify the effects of drugs on the central nervous system (CNS). A series of tones was presented at three random interstimulus intervals (ISI). The amplitude of N1-P2 and the recovery of this complex across ISI appear to be rapid, reliable and sensitive measures of changes in brain function associated with drug intake. To illustrate, an acute dose of diazepam was administered orally to a small group of normal subjects. The amplitude of N1-P2 was reduced and the slope of recovery flattened, indicating a decrease in CNS excitability concomitantly with the established pharmacokinetics of the drug.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Noldy NE,Neiman J,el-Nesr B,Carlen PLdoi
10.1159/000118715subject
Has Abstractpub_date
1990-01-01 00:00:00pages
48-52issue
1eissn
0302-282Xissn
1423-0224journal_volume
23pub_type
杂志文章abstract::The prevalence of 3,4-methylenedioxymethamphetamine (MDMA) use has increased globally and the pattern of consumption has changed considerably. Previously, a subculture of MDMA users was fairly restricted to the dance club scene. More recently, use has spread outside of this subculture and now many users consume MDMA f...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000253549
更新日期:2009-01-01 00:00:00
abstract::Sleep apnea is the most common sleep-related breathing disorder characterized by repetitive episodes of hypoxemia. Therapies include behavioral, surgical, orthodontic, pneumological, and pharmacological interventions. The aim of the present study was to compare the efficiency of pneumological therapy by nasal continuo...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000026575
更新日期:1999-01-01 00:00:00
abstract::Piracetam, when applied microiontophoretically and/or by hydropneumatic pump on the somatosensory cortex and hippocampus of the rat, affected neuronal activity by depressing or facilitating the spontaneous firing rate, depending on the area studied. Its effect were either additive or counteracting the actions of gluta...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118449
更新日期:1988-01-01 00:00:00
abstract::The aim of this paper was to determine whether the prolonged decrease in seizure threshold produced by chemical kindling was accompanied by behavioural changes in tests of anxiety and aggression. The responses of rats in five tests were examined after chronic treatment with the benzodiazepine inverse agonist FG7142. T...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118460
更新日期:1988-01-01 00:00:00
abstract::Neural-network pattern classifiers were used to study the effects of long half-life flurazepam (30 mg) and quazepam (15 mg), and short half-life triazolam (0.5 mg) on non-REM sleep. We measured the magnitude of effect, time course, and EEG spectral signature of the three benzodiazepines as a function of third-of-night...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118444
更新日期:1988-01-01 00:00:00
abstract::Performance on temporal discrimination of time intervals in the range of milliseconds is interpreted by the assumption of an internal clock; the higher the clock rate the better the temporal resolution of the internal clock will be, which is equivalent to more accuracy in timing of brief intervals. Although there is s...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000118899
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:Schizophrenia, a common neurological disorder appearing in the late teens or early adulthood, is characterized by disorganized thinking, behaviour, and perception of emotions. Aberrant N-methyl-D-aspartate (NMDA) receptor-mediated synaptic plasticity is a major pathological event here due to dysfunction of do...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000454985
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND/AIMS:Recent findings suggest an involvement of insulin-like growth factor-1 (IGF-1) in the pathogenesis of many psychiatric disorders; however, there is a lack of data regarding IGF-1 in patients with obsessive-compulsive disorder (OCD). The aims of the present study were (1) to analyze putative alterations ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000446918
更新日期:2016-01-01 00:00:00
abstract::Early N1P2 and late N2P3 responses generated in an auditory oddball paradigm are topographically compared in three psychiatric patient groups. In schizophrenia N1 and N2 amplitude is comparable with dementia and significantly decreased with respect to affective disorder. In contrast, P3 amplitude does not allow discri...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119343
更新日期:1997-01-01 00:00:00
abstract::The relationship between physical activity and mental health has been widely investigated, and several hypotheses have been formulated about it. Specifically, during the aging process, physical exercise might represent a potential adjunctive treatment for neuropsychiatric disorders and cognitive impairment, helping de...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000223730
更新日期:2009-01-01 00:00:00
abstract::This study investigated the acute effect of a dose range of low-to-moderate binge-like methamphetamine treatments on the regional expression of neurotrophin proteins in the brain and serum 2 h after the last dose, in addition to assessing the behavioural effects and dopamine neurotransmitter changes produced. Male Spr...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000480513
更新日期:2017-01-01 00:00:00
abstract::The formerly designed method for quantitative evaluation of drug effects in rats is employed for the classification of three different neuroleptic drugs, namely sulpiride, clozapine and haloperidol. Analysis of the power density spectra as obtained from the recorded activity in the cortex, striatum and reticular core ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118220
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND/AIMS:Suicidal behavior (SB) in bipolar disorder (BD) is a complex multifactorial event resulting from an interaction of genetic, neurobiological and psychosocial factors. Recent studies identified new possible mechanisms, suggesting a role for sirtuins (SIRTs 1-7), a family of nicotinamide adenine dinucleoti...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000446921
更新日期:2016-01-01 00:00:00
abstract::The cerebrospinal fluid (CSF) concentrations of the monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) as well as their ratios and correlations were analyzed in relation to the season of birth. The sample consisted of 241 drug-free patients par...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026561
更新日期:1999-01-01 00:00:00
abstract::Neurobiological and pharmacological research has suggested that dysregulation of the central noradrenergic systems might be involved in the pathophysiology of attention deficit hyperactivity disorder (ADHD). Previous studies have demonstrated that the norepinephrine transporter gene (SLC6A2) is associated with ADHD. T...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000138916
更新日期:2008-01-01 00:00:00
abstract::This report presents the results of a retrospective analysis of pooled efficacy data from eight studies in which buspirone was compared to placebo in 520 patients with generalized anxiety disorder (GAD). In addition to evaluating overall efficacy in the composite patient data base, four criteria were used to identify ...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,meta分析,随机对照试验
doi:10.1159/000118837
更新日期:1992-01-01 00:00:00
abstract::The prevalence of an abnormal response to the 1 mg dexamethasone suppression test (DST) was examined in 40 inpatients suffering from a major depressive disorder (MDD), 17 inpatients suffering from schizophrenia, and 30 normal controls. 23.5% of the schizophrenics were DST nonsuppressors compared to 52.5% of MDD patien...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118252
更新日期:1986-01-01 00:00:00
abstract::The somnopolygraphs of 26 sober chronic alcoholics were compared with those of an age-matched control group, after approximately 25 days of sobriety. The sleep efficiency index and latency to sleep onset were significantly disturbed in alcoholic subjects. There was a decrease in the number of REM episodes. Slow-wave s...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118169
更新日期:1985-01-01 00:00:00
abstract:BACKGROUND/AIMS/METHODS:Electroconvulsive therapy (ECT) is still one of the most potent treatments in the acute phase of major depressive disorder (MDD) and particularly applied in patients considered treatment resistant. However, despite the frequent and widespread use of ECT for >70 years, the exact neurobiological m...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000505553
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Testosterone has been postulated as a 'social' hormone, but the relationship between testosterone and personality traits linked with socially oriented behaviors such as extraversion remains unclear. The objective of our study was to investigate the association between baseline salivary testosterone levels an...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000369024
更新日期:2015-01-01 00:00:00
abstract::Plasma levels of free and conjugated 3,4-dihydroxyphenylethyleneglycol (DOPEG), the main deaminated metabolite of norepinephrine, were assayed in 48 depressed patients before initiating a treatment with either maprotiline, an inhibitor of norepinephrine reuptake, or indalpine, a specific inhibitor of serotonin reuptak...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118243
更新日期:1986-01-01 00:00:00
abstract::There is evidence that serotonin and norepinephrine are in some way involved in the pathophysiology of anxiety disorders. Urinary levels of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) and the norepinephrine metabolite vanillylmandelic acid (VMA) were measured in 46 patients with generalized anxiety di...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119165
更新日期:1995-01-01 00:00:00
abstract::The antidepressive and anxiolytic efficacy of flupenthixol has been investigated in numerous controlled and open trials involving patients with endogenous, reactive as well as senile depressions. When administered at a mean daily single or multiple dose of 1-2 mg, flupenthixol proved to be a very effective and well-to...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117999
更新日期:1983-01-01 00:00:00
abstract::The new anticonvulsant, lamotrigine, is becoming an important tool in the treatment of bipolar disorder, including bipolar depression. Its efficacy in bipolar depression might be linked to its inhibition of serotonin uptake. We present the case of a female schizoaffective patient successfully treated with 400 mg of la...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026538
更新日期:1998-10-01 00:00:00
abstract::Actions of the new antiepileptic drug lamotrigine (LTG) were characterized using extracellular and whole cell patch clamp recordings from rat CA1 and CA3 pyramidal cells in vitro. The results suggest that LTG, beside its previously described effect on the fast sodium inward current, also modulates - presumably voltage...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026528
更新日期:1998-10-01 00:00:00
abstract::Twelve healthy male volunteers received pyritinol 600 or 1,200 mg or placebo for 3 days according to a randomised, double-blind crossover design. On the 1st and 3rd days of each of the three treatment periods subjects completed a battery of psychological tests including Critical Flicker Fusion (CFFT), Choice Reaction ...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000119478
更新日期:1990-01-01 00:00:00
abstract:BACKGROUND:Psychosis spectrum disorders, especially schizophrenia, have been linked to disturbed dopaminergic activity in the brain. Plasma homovanillic acid (pHVA) levels partly represent dopaminergic metabolism in the central nervous system. In the present study associations between (changes in) pHVA levels, symptom ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000431095
更新日期:2015-01-01 00:00:00
abstract::Recent findings indicate that the memory-impairing effects of benzodiazepines may preferentially involve the basolateral nucleus of the amygdala. To test this hypothesis we examined the effects on pretrial injection of diazepam into the central as compared to the lateral/basolateral amygdaloid nuclei on memory for a c...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119209
更新日期:1995-01-01 00:00:00
abstract::The relationship between clinical effect of imipramine (IP) in 39 depressed patients and biochemical distinction, serum drug levels, and diagnostic classification was investigated retrospectively. Based on pretreatment plasma ratios of tryptophan and tyrosine to competing amino acids, which reflect the availability of...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118182
更新日期:1985-01-01 00:00:00
abstract::Acute quantitative electroencephalographic effects of cigarette smoking were examined in 15 smokers within a repeated-measures design which assessed changes in power-spectral estimates following acute pre-treatment with placebo, a dose (20 mg) of mecamylamine, a dose (0.6 mg) of scopolamine and a combined dose of meca...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026524
更新日期:1998-01-01 00:00:00