Abstract:
:An association between negative symptoms and frontal cortex abnormalities has been suggested in schizophrenic patients. We tested whether this association can be found when patients' task performance is good and while controlling for possible cortical atrophy. We investigated regional cerebral blood flow with the xenon-133 inhalation method in 9 unmedicated schizophrenic patients at rest and during performance of the Continuous Performance Test. Negative symptoms were quantified with the Scale for Assessment of Negative Symptoms. All patients could attend to the test and performed it successfully with mean accuracy of 91 +/- 8%. Changes of the left hemisphere hyperfrontality ratio were significantly correlated with severity of negative symptoms, especially for the subscales of attention (r = -0.83) and anhedonia (r = -0.70). These results lend further support to the putative association between negative symptoms and physiological abnormalities of the frontal cortex in schizophrenic patients.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Zemishlany Z,Alexander GE,Prohovnik I,Goldman RG,Mukherjee S,Sackeim Hdoi
10.1159/000119262subject
Has Abstractpub_date
1996-01-01 00:00:00pages
127-31issue
3eissn
0302-282Xissn
1423-0224journal_volume
33pub_type
杂志文章abstract::Possible age effects on binding of [(3)H]lysergic acid diethylamide ([(3)H]LSD) to serotonin 5-HT(2A) receptors and of [(3)H]paroxetine to serotonin uptake sites were studied in platelets from healthy children (11-12 years of age), adolescents (16-17 years of age) and adults. Significant overall age effects were found...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026617
更新日期:1999-11-01 00:00:00
abstract::Schizophrenia is a heterogeneous and multidimensional disorder. The different syndromes or dimensions of this disorder represent distinct pathophysiological processes. Evidence is growing that each of the composite syndromes or dimensions of this disorder is associated with specific validators. This article reviewed n...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000119310
更新日期:1996-01-01 00:00:00
abstract::Symptoms of anxiety suggest autonomic dysfunction and most of the psychotropic agents used to treat anxiety and affective disorders have strong autonomic effects. This article describes the utility and importance of analysis of heart rate and blood pressure time series to study cardiac autonomic function in psychiatri...
journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000119234
更新日期:1995-01-01 00:00:00
abstract::The effects of the dopaminergic agonists (L-dopa, pergolide) and antagonists (haloperidol, clozapin) and a cholinergic agonist (tacrine) and antagonist (mecamylamine) on the voluntary intake of nicotine were investigated with the 2-bottle paradigm with the test drugs being dissolved directly in the drinking fluid of t...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026661
更新日期:2000-01-01 00:00:00
abstract::Quantitative assessment of regional cerebral blood flow (rCBF) was performed in a 22-year-old man with intractable temporal lobe epilepsy on long-term high-dose phenytoin (PHT) therapy, using single photon emission computed tomography (SPECT) with N-isopropyl-(iodine-123)-p-iodoamphetamine. In all the SPECT scans repe...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118982
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:The present study investigated the effects of rapid tryptophan depletion (RTD), and the ensuing reduction of central nervous system levels of serotonin (5-HT), upon reactive aggression in patients with attention deficit/hyperactivity disorder (ADHD). Furthermore, it was asked whether the relation between 5-H...
journal_title:Neuropsychobiology
pub_type: 杂志文章,随机对照试验
doi:10.1159/000112951
更新日期:2007-01-01 00:00:00
abstract::Two preliminary studies have indicated a variation in season of birth in severely language-disordered children. In the current study, the season of birth in 472 Danish children with language disorder born between 1958 and 1976 was compared with the season of birth of all Danish live-born children in the same period. F...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000084166
更新日期:2005-01-01 00:00:00
abstract::Twenty-three chronic undifferentiated schizophrenics, 13 women and 10 men, aged 37-64 years with 15-to 40-year histories of the disease were given either thyrotropin-releasing hormone (TRH) (10 subjects) or DDAVP (13 subjects) with the aim to improve the negative symptoms of the disease and memory. TRH (600 micrograms...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118253
更新日期:1986-01-01 00:00:00
abstract::We have previously shown that the tilt aftereffect (TAE) appears to respond to changes in central dopaminergic function. In this study, the TAE was investigated during the preovulatory and the premenstrual phases of the menstrual cycle. Results in the preovulatory phase mimicked those previously found associated with ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119484
更新日期:1990-01-01 00:00:00
abstract::In the past, some researchers found increased cortisol and prolactin responses to the administration of fenfluramine in major-depressed patients. It was believed that the fenfluramine test could prove to constitute another challenge probe to reflect the central serotonergic function. The present study was conducted in...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118576
更新日期:1989-01-01 00:00:00
abstract::An auditory event-related potential paradigm was designed to objectively quantify the effects of drugs on the central nervous system (CNS). A series of tones was presented at three random interstimulus intervals (ISI). The amplitude of N1-P2 and the recovery of this complex across ISI appear to be rapid, reliable and ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118715
更新日期:1990-01-01 00:00:00
abstract::The purpose of this study was to investigate the relationship between postoperative confusion and the plasma norepinephrine (NE), adrenocorticotropin (ACTH) or cortisol response to surgery in schizophrenic patients. We studied 50 schizophrenic patients and 35 control patients who underwent orthopedic surgery and perio...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000063569
更新日期:2002-01-01 00:00:00
abstract::In the Lundby Study, all mental illnesses, treated as well as untreated, that occurred during a 25-year period in a geographically defined Swedish general population sample were evaluated. All forms of psychiatric services used by the population during the same period were registered. The present study investigates th...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117990
更新日期:1983-01-01 00:00:00
abstract::Hallucinogenic drug-induced states are considered as models for acute schizophrenic disorders (experimental psychoses). In a double-blind study with healthy volunteers we investigated the influence of the serotonergic hallucinogen psilocybin, the ecstasy-like drug 3,4-methylenedioxyethylamphetamine (MDE), the stimulan...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000063672
更新日期:2002-01-01 00:00:00
abstract::Knowledge in neuropsychobiology continues to benefit from the use of drugs as 'tools' to alter neurochemical events as a means of studying interactions between the events and behaviour. Before drugs could play such a role, concepts about basic properties of living organism had to be refined. Techniques had to be inven...
journal_title:Neuropsychobiology
pub_type: 历史文章,杂志文章
doi:10.1159/000118407
更新日期:1987-01-01 00:00:00
abstract::Plasma noradrenaline (NA), adrenaline (Ad), dopamine (DA), platelet serotonin (p5HT), free serotonin (f5HT), glucose, heart rate (HR) and blood pressure (BP) were measured before and after an oral load of glucose (OGTT) in 100 normal humans. One sham-feeding test was performed in every subject 2-3 weeks before OGTT. A...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118889
更新日期:1992-01-01 00:00:00
abstract::In 63 depressed patients, the associations between severity of depression, psychomotor retardation, assessed by the Bech-Rafaelsen Melancholia Scale, and EEG spectral analysis were examined. Slow EEG activity (theta 2/alpha 1 bands) was positively and fast activity (alpha 3/beta bands) negatively correlated with the o...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118804
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Lithium augmentation is a first-line strategy for depressed patients resistant to antidepressive therapy, but little is known about patients' subsequent long-term course or outcome predictors. We investigated long-term outcomes of unipolar depressed patients who had participated in a study on the effects of ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000234814
更新日期:2009-01-01 00:00:00
abstract::In the present study all available young social alcohol abusers in the capital of Iceland are compared with a control group matched for age and intellectual level. Certain behaviour and social characteristics were found to occur more often during childhood among the abusers. Boys showing these characteristics should b...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117483
更新日期:1975-01-01 00:00:00
abstract::Time trends and periodic cycles in REM sleep eye movements were examined in 6 functional and 6 mongoloid adolescent retardates. Both groups of subjects showed approximately equal percentages of linear trends, quadratic trends, linear and quadratic trends, and absence of trend. The eye movement time-series were subject...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117524
更新日期:1976-01-01 00:00:00
abstract:BACKGROUND:Derangements of the gut microbiome have been linked to increased systemic inflammation and central nervous system disorders, including schizophrenia. This systematic review thus aimed to investigate the hypothesis that probiotic supplementation improves schizophrenia symptoms. METHODS:By using the keywords ...
journal_title:Neuropsychobiology
pub_type: 杂志文章,meta分析
doi:10.1159/000498862
更新日期:2019-01-01 00:00:00
abstract::A sample of schizophrenic inpatients and a control sample of normal volunteers, matched for age and sex were tested on two tasks before and after an exposure condition in which they pointed repeatedly to a target while viewing their hands and the target through prisms. Both groups showed significant changes in both ta...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117753
更新日期:1980-01-01 00:00:00
abstract::Actions of the new antiepileptic drug lamotrigine (LTG) were characterized using extracellular and whole cell patch clamp recordings from rat CA1 and CA3 pyramidal cells in vitro. The results suggest that LTG, beside its previously described effect on the fast sodium inward current, also modulates - presumably voltage...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026528
更新日期:1998-10-01 00:00:00
abstract::Little information exists on the concentrations of recent antidepressants and their metabolites in cerebrospinal fluid (CSF). Using a stereoselective method, we measured plasma and CSF levels of mirtazapine (MIR), N-demethylmirtazapine and 8-OH-MIR in 3 depressed patients treated with racemic MIR (45 mg/day) for 4 wee...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000098654
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:The rs1344706 single nucleotide polymorphism in the ZNF804A gene is a common variant with strong evidence for association with schizophrenia. Recent studies show an association of rs1344706 with cognitive functioning, and there is some evidence suggesting that the risk allele may increase susceptibility for ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000339731
更新日期:2012-01-01 00:00:00
abstract::The formerly designed method for quantitative evaluation of drug effects in rats is employed for the classification of three different neuroleptic drugs, namely sulpiride, clozapine and haloperidol. Analysis of the power density spectra as obtained from the recorded activity in the cortex, striatum and reticular core ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118220
更新日期:1985-01-01 00:00:00
abstract::During interictal periods in 9 patients with partial epilepsy we examined whether there were correlations between the relative power of background EEG (power spectral analysis) and the absolute values of regional cerebral blood flow (rCBF) measured by 99mTc hexamethylpropylene amine oxime (HMPAO) SPECT in each cerebra...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119135
更新日期:1994-01-01 00:00:00
abstract::The responses of cortisol to acute administration of saline and of clonidine (2.5 micrograms/kg B.W.) were examined in 10 children and adolescents with major depressive disorder and in 10 age- and sex-matched controls. Clonidine administration did not inhibit cortisol secretion in controls or in patients, contrary to ...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000119022
更新日期:1993-01-01 00:00:00
abstract::This report presents the results of a retrospective analysis of pooled efficacy data from eight studies in which buspirone was compared to placebo in 520 patients with generalized anxiety disorder (GAD). In addition to evaluating overall efficacy in the composite patient data base, four criteria were used to identify ...
journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,meta分析,随机对照试验
doi:10.1159/000118837
更新日期:1992-01-01 00:00:00
abstract:INTRODUCTION:REM sleep behavior disorder (RBD) is considered a prodromal phase of α-synucleinopathy like Parkinson disease (PD). PD is characterized by a progressive decline of dopamine (DA) in the striatum. Here we report the surprising increase in DA transporter density over successive years in an RBD patient treated...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000488893
更新日期:2017-01-01 00:00:00