Abstract:
:A common polymorphism in the alpha1-antichymotrypsin (ACT) gene is associated with Alzheimer's disease. ACT is also a trophic factor in the hippocampal neurons. In order to examine if the ACT gene plays a role in the pathogenesis of schizophrenic disorders, patients (n = 175) and control subjects (n = 114) were genotyped for ACT. We also investigated the relationship between genotypes and patients' cognitive function as evaluated by the Clinical Dementia Rating Scale and the Mini-Mental State Examination. The results demonstrated no association between schizophrenia and/or cognitive deficit in schizophrenia and ACT polymorphism. The data suggest that the ACT gene is not of major importance for the genesis of schizophrenia. Further studies measuring ACT expression as messenger RNA or serum ACT level may help to exclude the role of ACT in the pathogenesis of schizophrenia.
journal_name
Neuropsychobiologyjournal_title
Neuropsychobiologyauthors
Chiu HJ,Hong CJ,Chen JY,Wang YC,Lin CY,Bai YM,Song HL,Lai HC,Tsai SJdoi
10.1159/000026600keywords:
subject
Has Abstractpub_date
1999-01-01 00:00:00pages
71-4issue
2eissn
0302-282Xissn
1423-0224pii
26600journal_volume
40pub_type
杂志文章abstract::Alcohol-dependent patients face a substantial risk of relapse after detoxification. Though psychosocial stress and coping strategies are regarded as major contributing factors in returning to drinking, the direct effects of coping styles on relapse are not clear. In this treatment outcome study, a mixed gender sample ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000096991
更新日期:2006-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026528
更新日期:1998-10-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117595
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118606
更新日期:1989-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117548
更新日期:1976-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000054930
更新日期:2001-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118040
更新日期:1984-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000122268
更新日期:2007-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000366488
更新日期:2014-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118495
更新日期:1988-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000085595
更新日期:2005-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000337740
更新日期:2012-01-01 00:00:00
abstract::The systematic recording of spontaneous electrodermal activity (EDA) on 23 normal subjects during 5 15-min sessions and the self-rating of anxious and/or depressive moods (Q-sort forced choice) shows a positive linear relationship between spontaneous EDA and anxious mood despite a low covariation between those two var...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000117616
更新日期:1978-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章,meta分析
doi:10.1159/000498862
更新日期:2019-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000076416
更新日期:2004-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000441191
更新日期:2016-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118112
更新日期:1984-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000026524
更新日期:1998-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000317284
更新日期:2010-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000499976
更新日期:2019-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000487859
更新日期:2017-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000327604
更新日期:2011-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章
doi:10.1159/000119383
更新日期:1997-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000119058
更新日期:1994-01-01 00:00:00
abstract::As low-dose amphetamine stimulation of locomotor activity in the rat depends upon a mesolimbic dopaminergic substrate, neuroleptic antagonism of this behavior has been suggested as a model for studying antipsychotic activity. Animals in the present study received 21 days of chronic treatment with 1.0 mg/kg amphetamine...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118442
更新日期:1988-01-01 00:00:00
abstract::In two studies experimentally induced colds slowed the speed of response in a serial reaction task. Responding was also slower during the incubation period of the illness, which shows that performance on such a task may be used to predict subsequent illness. Volunteers who had no significant clinical illness, but who ...
journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000118408
更新日期:1987-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000223730
更新日期:2009-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章
doi:10.1159/000319359
更新日期:2010-08-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 杂志文章,评审
doi:10.1159/000119234
更新日期:1995-01-01 00:00:00
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journal_title:Neuropsychobiology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2005-01-01 00:00:00