解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Programmed death-ligand 1 (PD-L1) is a co-inhibitory molecule expressed on tumor cells. Immune checkpoint inhibitors focusing on the PD-L1 mechanism are now being studied for the treatment of various cancer types. However, the regulatory mechanism of PD-L1 is yet to be fully clarified, and a high-throughput system for...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.14032
更新日期:2021-01-09 00:00:00
abstract::Leishmania internalize hemoglobin (Hb) via a specific receptor (HbR) for their survival. To identify the Hb-binding domain of HbR, we cloned and expressed several truncated proteins of HbR and determined their ability to bind Hb. Our findings reveal that 90% of Hb-binding activity is retained in HbR41-80 in comparison...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.14027
更新日期:2020-12-14 00:00:00
abstract::Pathway analysis methods are frequently applied to cancer gene expression data to identify dysregulated pathways. These methods often infer pathway activity based on the expression of genes belonging to a given pathway, even though the proteins ultimately determine the activity of a given pathway. Furthermore, the ass...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.14011
更新日期:2020-12-01 00:00:00
abstract::To address biophysical principles and lipid interactions that underlie the properties of membrane proteins, modifications that vary the neighbors of tryptophan residues in the highly dynamic transmembrane helix of GW4,20 ALP23 (acetyl-GGAW4 A(LA)6 LAW20 AGA-amide) were examined using deuterium NMR spectroscopy. It was...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13926
更新日期:2020-12-01 00:00:00
abstract::Mitochondrial translocation of ceramides triggers Bax-dependent apoptosis. To elucidate how ceramides activate Bax and commit cells to death, we developed a switchable version of the ceramide transfer protein CERT, sCERT. Upon its drug-induced recruitment to mitochondria, sCERT retains the ability to bind VAP proteins...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13956
更新日期:2020-11-01 00:00:00
abstract::Barth syndrome (BTHS) is a rare X-linked genetic disorder caused by mutations in the gene encoding the transacylase tafazzin and characterized by loss of cardiolipin and severe cardiomyopathy. Mitochondrial oxidants have been implicated in the cardiomyopathy in BTHS. Eleven mitochondrial sites produce superoxide/hydro...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13973
更新日期:2020-10-28 00:00:00
abstract::In the past two decades, the ATP-binding cassette (ABC) transporters' field has undergone a structural revolution. The importance of structural biology to the development of the field of ABC transporters cannot be overstated, as the ensemble of structures not only revealed the architecture of ABC transporters but also...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.13966
更新日期:2020-10-24 00:00:00
abstract::The ABCG2 protein has a key role in the transport of a wide range of structurally dissimilar endo- and xenobiotics in the human body, especially in the tissue barriers and the metabolizing or secreting organs. The human ABCG2 gene harbors a high number of polymorphisms and mutations, which may significantly modulate i...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.13947
更新日期:2020-10-04 00:00:00
abstract::We used transcriptomic (RNA-seq) analyses to determine whether patients suffering from all types and subtypes of mucopolysaccharidosis (MPS), a severe inherited metabolic disease, may be more susceptible to coronavirus disease 2019 (COVID-19). The expression levels of genes encoding proteins potentially involved in SA...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13908
更新日期:2020-10-01 00:00:00
abstract::Apomyoglobin is a widely used model for studying the molecular mechanisms of globular protein folding. This work aimed to analyze the effects of rigidity and length of loops linking protein secondary structure elements on the stability of the molten globule intermediate state. For this purpose, we studied folding/unfo...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13905
更新日期:2020-10-01 00:00:00
abstract::Proteolytic processing is an important post-translational modification affecting protein activity and stability. In the current study, we investigate the N-terminal cleavage of Trop2, a protein which is overexpressed in many cancers. We demonstrate that Trop2 is cleaved at Arg87 by a transmembrane serine protease, mat...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13899
更新日期:2020-10-01 00:00:00
abstract::Choroidal melanoma (CM) remains the most prevalent form of intraocular malignancy, and the prognosis of affected patients is poor. While the E3 ubiquitin ligase TRAF-interacting protein (TRIP) is known to play key regulatory roles in multiple diseases, its relevance in CM remains uncertain. In the present study, we fo...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13882
更新日期:2020-10-01 00:00:00
abstract::6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 (PFKFB3) is a key enzyme of the glycolytic pathway, and it plays an essential role in angiogenesis. 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO) is frequently used as a glycolysis inhibitor and is thought to inhibit PFKFB3. However, this latter eff...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13878
更新日期:2020-09-01 00:00:00
abstract::The cytochrome bc1 complex is a key component of the mitochondrial respiratory chains of many eukaryotic microorganisms that are pathogenic for plants or humans, such as fungi responsible for crop diseases and Plasmodium falciparum, which causes human malaria. Cytochrome bc1 is an enzyme that contains two (ubi)quinone...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.13868
更新日期:2020-09-01 00:00:00
abstract::Mutations in the nuclear matrix protein Matrin 3 (MATR3) have been identified in amyotrophic lateral sclerosis and myopathy. To investigate the mechanisms underlying MATR3 mutations in neuromuscular diseases and efficiently screen for modifiers of MATR3 toxicity, we generated transgenic MATR3 flies. Our findings indic...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13858
更新日期:2020-09-01 00:00:00
abstract::Streptococci are a broad group of Gram-positive bacteria. This genus includes various human pathogens causing significant morbidity and mortality. Two of the most important human pathogens are Streptococcus pneumoniae (pneumococcus) and Streptococcus pyogenes (group A streptococcus or GAS). Streptococcal pathogens hav...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.13872
更新日期:2020-08-01 00:00:00
abstract::Glycosylphosphatidylinositol (GPI) is synthesized in the endoplasmic reticulum (ER) and added onto proteins to form GPI-anchored proteins. Among the many proteins involved in this process, ACAT-related enzyme-2 required for viability 1 (Arv1) is a candidate, functioning as a flippase that translocates GPI intermediate...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13843
更新日期:2020-08-01 00:00:00
abstract::The malaria parasite has for long been thought to escape host complement attack as a survival strategy. However, it was only recently that complement evasion mechanisms of the parasite were described. Simultaneously, the role of complement in antibody-mediated naturally acquired and vaccine-induced protection against ...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.13772
更新日期:2020-08-01 00:00:00
abstract::STAT3, a transcription factor involved in various physiological and pathological processes, is also present in mitochondria. Mitochondrial STAT3 regulates complex I activity and reactive oxygen species (ROS) production, yet the mechanisms governing its translocation to mitochondria remain poorly understood. In this st...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13741
更新日期:2020-05-01 00:00:00
abstract::The rise of antibiotic resistance combined with the lack of new products entering the market has led to bacterial infections becoming one of the biggest threats to global health. Therefore, there is an urgent need to identify novel antibiotic targets, such as dihydrodipicolinate synthase (DHDPS), an enzyme involved in...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13733
更新日期:2020-05-01 00:00:00
abstract::Adequate dietary intake of essential metals such as zinc is important for maintaining homeostasis. Abnormal zinc intake in Caenorhabditis elegans has been shown to increase or decrease normal lifespan by influencing the insulin/IGF-1 pathway. Distribution of zinc is achieved by a family of highly conserved zinc transp...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13725
更新日期:2020-05-01 00:00:00
abstract::Coronin proteins are widely expressed among eukaryotic organisms. Most coronins consist of a WD-repeat domain followed by a C-terminal coiled coil. Dictyostelium discoideum expresses a single short coronin coronin A, which has been implicated in both actin modulation and multicellular differentiation. Whether coronin ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13787
更新日期:2020-04-16 00:00:00
abstract::Neurofibrillary tangles formed by abnormally aggregated tau protein are a histopathological feature of tauopathies. A tau aggregation inhibitor is a potential therapeutic agent for tauopathies. In this study, we prepared a monoclonal antibody for tau, monoclonal antibody to tau protein (Tau2r3), using as epitope the 2...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13791
更新日期:2020-04-13 00:00:00
abstract::Autophagy is an evolutionarily conserved stress response that promotes the lysosomal degradation of intracellular components. The bone marrow stromal cell-derived growth inhibitor (BDGI) functions as a stress sensor which is upregulated by oxidative stress and DNA damage. However, the role of BDGI in autophagic respon...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13732
更新日期:2020-04-01 00:00:00
abstract::Cellular homeostasis in response to glucose availability is maintained through the tight coordination of various physiological processes, including cell proliferation, transcription, and metabolism. In this study, we use the budding yeast Saccharomyces cerevisiae to identify proteins implicated in carbon source-depend...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13722
更新日期:2020-04-01 00:00:00
abstract::Anillin is a type of actin filament cross-linking protein that stabilizes the actin-based contractile ring during cytokinesis. To elucidate the underlying intermolecular interactions between actin filaments and anillin, we utilized total internal reflection fluorescence microscopy (TIRFM) and high-speed atomic force m...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13720
更新日期:2020-04-01 00:00:00
abstract::The ∆Np63 isoform of the p53-family transcription factor Trp63 is a key regulator of mammary epithelial stem cells that is involved in breast cancer development. To investigate the role of ∆Np63 at different stages of normal mammary gland development, we generated a ∆Np63-inducible conditional knockout (cKO) mouse mod...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13703
更新日期:2020-03-01 00:00:00
abstract::α-Helical membrane-active antimicrobial peptides (AMPs) are known to act via a range of mechanisms, including the formation of barrel-stave and toroidal pores and the micellisation of the membrane (carpet mechanism). Different mechanisms imply that the peptides adopt different 3D structures when bound at the water-mem...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13705
更新日期:2020-03-01 00:00:00
abstract::Proteins with a CyaB, thiamine triphosphatase domain (CYTH domain) may play a central role at the interface between nucleotide and polyphosphate metabolism. One of the plant CYTH domain-containing proteins from Brachypodium distachyon, BdTTM3, is annotated in NCBI databases as an 'adenylyl cyclase (AC)' or a 'triphosp...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13701
更新日期:2020-03-01 00:00:00
abstract::The hirudin-like factor 1 (HLF1) of Hirudo medicinalis belongs to a new class of leech-derived factors. In previous investigations, HLF1 did not exhibit anticoagulatory activities. Here, we describe the analysis of natural and synthetic variants of HLF1 and HLF-Hyb, a yet uncharacterized member of the HLF family. Modi...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13683
更新日期:2020-03-01 00:00:00
abstract::Cytochrome c oxidase is a membrane-bound redox-driven proton pump that harbors two proton-transfer pathways, D and K, which are used at different stages of the reaction cycle. Here, we address the question if a D pathway with a modified energy landscape for proton transfer could take over the role of the K pathway whe...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13679
更新日期:2020-03-01 00:00:00
abstract::Physicochemical properties of proteins are controlled mainly by post-translational modifications such as amino acid phosphorylation. Although molecular dynamics simulations have been shown to be a valuable tool for studying the effects of phosphorylation on protein structure and dynamics, most of the previous studies ...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13674
更新日期:2020-03-01 00:00:00
abstract::The nucleotide binding protein 35 (Nbp35)/cytosolic Fe-S cluster deficient 1 (Cfd1)/alternative pyrimidine biosynthetic protein C (ApbC) protein homologs have been identified in all three domains of life. In eukaryotes, the Nbp35/Cfd1 heterocomplex is an essential Fe-S cluster assembly scaffold required for the matura...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13673
更新日期:2020-03-01 00:00:00
abstract::Polyhydroxyalkanoate (PHA) synthases catalyze the polymerization reaction of the acyl moiety of hydroxyacyl-coenzyme A into polyester. The catalytic subunit PhaC of PHA synthase has the PhaC box sequence at the active site that is typically described as G-X-C-X-G-G (X is an arbitrary amino acid), and cysteine is an ac...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13651
更新日期:2020-02-01 00:00:00
abstract::Physiological and pathophysiological differences exist between the left and right kidneys; however, the molecular bases for these differences remain unknown. Since miRNAs are involved in kidney function and the development of kidney diseases, we examined their differential expression through miRNA profiling of the lef...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13644
更新日期:2020-02-01 00:00:00
abstract::The retinal pigment epithelium-specific 65 kDa (RPE65) isomerase plays a pivotal role in photoreceptor survival and function. RPE65-catalyzed synthesis of 11-cis-retinol from all-trans-retinyl esters in the visual cycle is negatively regulated, through a heretofore unknown mechanism, by the fatty acid transport protei...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13633
更新日期:2020-02-01 00:00:00
abstract::The fibronectin type II (FnII) domain, present in diverse vertebrate proteins, plays crucial roles in several fundamental biological processes. PDC-109, the major bovine seminal plasma protein, contains two FnII domains that bind to choline phospholipids on sperm plasma membrane and induce lipid efflux crucial for suc...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13617
更新日期:2020-02-01 00:00:00
abstract::Polyphosphates (polyP) are long chains of inorganic phosphates that can be attached to lysine residues of target proteins as a nonenzymatic post-translational modification. This modification, termed polyphosphorylation, may be particularly prevalent in bacterial and fungal species that synthesize large quantities of p...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13588
更新日期:2020-01-01 00:00:00
abstract::UBR5 is an E3 ubiquitin ligase involved in distinct processes such as transcriptional regulation and development. UBR5 is highly upregulated in embryonic stem cells (ESCs), whereas its expression decreases with differentiation, suggesting a role for UBR5 in ESC function. However, little is known about how UBR5 regulat...
journal_title:FEBS letters
pub_type: 杂志文章
doi:10.1002/1873-3468.13559
更新日期:2020-01-01 00:00:00
abstract::Blood reprogramming, in which induced pluripotent stem cells (iPSCs) are derived from haematopoietic lineages, has rapidly advanced over the past decade. Since the first report using human blood, haematopoietic cell types from various sources, such as the peripheral bone marrow and cord blood, have been successfully r...
journal_title:FEBS letters
pub_type: 杂志文章,评审
doi:10.1002/1873-3468.13659
更新日期:2019-12-01 00:00:00