Abstract:
:Cellular homeostasis in response to glucose availability is maintained through the tight coordination of various physiological processes, including cell proliferation, transcription, and metabolism. In this study, we use the budding yeast Saccharomyces cerevisiae to identify proteins implicated in carbon source-dependent modulation of physiological processes. We find that the mitotic cyclin Clb4 is required for optimal regulation of glucose-starvation-responsive pathways through the target of rapamycin complex 1. Cells lacking Clb4 are characterized by dysregulation of autophagy and impaired modulation of cell size. Notably, cell viability after prolonged glucose starvation is severely reduced by disruption of Clb4. We conclude that Clb4, in addition to its function in the cell cycle, plays a role in the intracellular adaptation to glucose starvation.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Umekawa M,Shiraishi D,Fuwa M,Sawaguchi K,Mashima Y,Katayama T,Karita Sdoi
10.1002/1873-3468.13722subject
Has Abstractpub_date
2020-04-01 00:00:00pages
1329-1338issue
8eissn
0014-5793issn
1873-3468journal_volume
594pub_type
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