Abstract:
:The assembly of the Sm-class of uridine-rich small nuclear ribonucleoproteins (U snRNPs), albeit spontaneous in vitro, has recently been shown to be dependent on the aid of a large number of assisting factors in vivo. These factors are organized in two interacting units termed survival motor neuron (SMN)- and protein arginine methyltransferase 5 (PRMT5)-complexes, respectively. While the PRMT5-complex acts early in the assembly pathway by activating common proteins of U snRNPs, the SMN-complex functions to join proteins and RNA in a highly ordered, apparently regulated manner. Here, we summarize recent progress in the understanding of this process and discuss the influence exerted by the aforementioned trans-acting factors.
journal_name
FEBS Lettjournal_title
FEBS lettersauthors
Neuenkirchen N,Chari A,Fischer Udoi
10.1016/j.febslet.2008.03.009subject
Has Abstractpub_date
2008-06-18 00:00:00pages
1997-2003issue
14eissn
0014-5793issn
1873-3468pii
S0014-5793(08)00235-4journal_volume
582pub_type
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